Display Settings:

Format

Send to:

Choose Destination

SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 [ Homo sapiens (human) ]

Gene ID: 6546, updated on 7-Dec-2014
Official Symbol
SLC8A1provided by HGNC
Official Full Name
solute carrier family 8 (sodium/calcium exchanger), member 1provided by HGNC
Primary source
HGNC:HGNC:11068
See related
HPRD:01659; MIM:182305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCX1
Summary
In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM, Apr 2004]
See SLC8A1 in Epigenomics, MapViewer
Location:
2p22.1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (40112146..40512476, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (40339286..40739575, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene THUMP domain containing 2 Neighboring gene zinc finger protein 19 pseudogene Neighboring gene SLC8A1 antisense RNA 1 Neighboring gene uncharacterized LOC101929667 Neighboring gene uncharacterized LOC101929700 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 57

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A common variant in SLC8A1 is associated with the duration of the electrocardiographic QT interval.
NHGRI GWA Catalog
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study of neurocognitive impairment and dementia in HIV-infected adults.
NHGRI GWA Catalog
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
NHGRI GWA Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem (from WikiPathways)
    Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystemAdapted from KEGG: http://www.genome.jp/kegg/pathway/hsa/hsa05412.html
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem (from KEGG)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystemArrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are prog...
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
    Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Cardiac muscle contraction, conserved biosystem (from KEGG)
    Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
  • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
    Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Dilated cardiomyopathy, conserved biosystem (from KEGG)
    Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
  • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
    Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
    Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
    Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
  • Platelet homeostasis, organism-specific biosystem (from REACTOME)
    Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
  • Protein digestion and absorption, organism-specific biosystem (from KEGG)
    Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Protein digestion and absorption, conserved biosystem (from KEGG)
    Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
  • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
    Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Sodium/Calcium exchangers, organism-specific biosystem (from REACTOME)
    Sodium/Calcium exchangers, organism-specific biosystemCalcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracell...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
    Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...
  • cGMP-PKG signaling pathway, organism-specific biosystem (from KEGG)
    cGMP-PKG signaling pathway, organism-specific biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
  • cGMP-PKG signaling pathway, conserved biosystem (from KEGG)
    cGMP-PKG signaling pathway, conserved biosystemCyclic GMP (cGMP) is the intracellular second messenger that mediates the action of nitric oxide (NO) and natriuretic peptides (NPs), regulating a broad array of physiologic processes. The elevated i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ37694, FLJ43417, MGC119581, DKFZp779F0871

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ankyrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
ankyrin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium:sodium antiporter activity IDA
Inferred from Direct Assay
more info
PubMed 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
PubMed 
ion channel binding ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
blood coagulation TAS
Traceable Author Statement
more info
 
calcium ion export IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
calcium ion import IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion transport into cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle cell development ISS
Inferred from Sequence or Structural Similarity
more info
 
cardiac muscle contraction TAS
Traceable Author Statement
more info
PubMed 
cell communication by electrical coupling involved in cardiac conduction ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to caffeine ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to reactive oxygen species IDA
Inferred from Direct Assay
more info
PubMed 
cellular sodium ion homeostasis IDA
Inferred from Direct Assay
more info
PubMed 
cytosolic calcium ion transport TAS
Traceable Author Statement
more info
PubMed 
embryonic heart tube development IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
heart morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ion transport TAS
Traceable Author Statement
more info
 
membrane depolarization during cardiac muscle cell action potential TAS
Traceable Author Statement
more info
PubMed 
muscle contraction TAS
Traceable Author Statement
more info
PubMed 
muscle fiber development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cytosolic calcium ion concentration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of the force of heart contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic development IEA
Inferred from Electronic Annotation
more info
 
regulation of cardiac muscle contraction by calcium ion signaling TAS
Traceable Author Statement
more info
PubMed 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion TAS
Traceable Author Statement
more info
PubMed 
regulation of cell communication by electrical coupling TAS
Traceable Author Statement
more info
PubMed 
regulation of heart rate ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of the force of heart contraction IC
Inferred by Curator
more info
PubMed 
regulation of the force of heart contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
relaxation of cardiac muscle IC
Inferred by Curator
more info
PubMed 
relaxation of cardiac muscle TAS
Traceable Author Statement
more info
PubMed 
relaxation of smooth muscle ISS
Inferred from Sequence or Structural Similarity
more info
 
response to muscle stretch IMP
Inferred from Mutant Phenotype
more info
PubMed 
sodium ion export IDA
Inferred from Direct Assay
more info
PubMed 
sodium ion import IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane transport TAS
Traceable Author Statement
more info
 
vascular smooth muscle contraction ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
T-tubule ISS
Inferred from Sequence or Structural Similarity
more info
 
T-tubule TAS
Traceable Author Statement
more info
PubMed 
Z disc ISS
Inferred from Sequence or Structural Similarity
more info
 
basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
intercalated disc ISS
Inferred from Sequence or Structural Similarity
more info
 
intercalated disc TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
sarcolemma ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
sodium/calcium exchanger 1
Names
sodium/calcium exchanger 1
Na+/Ca++ exchanger
Na+/Ca2+ exchanger
Na(+)/Ca(2+)-exchange protein 1
solute carrier family 8 member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112800.1NP_001106271.1  sodium/calcium exchanger 1 isoform B precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (B) lacks an alternate in-frame exon in the central coding region, compared to variant A. The resulting protein is shorter than isoform A.
    Source sequence(s)
    AB209075, AC007254, AK291696, BC098285
    Consensus CDS
    CCDS46265.1
    UniProtKB/Swiss-Prot
    P32418
    UniProtKB/TrEMBL
    Q4QQH3
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4968
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:804957
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  2. NM_001112801.1NP_001106272.1  sodium/calcium exchanger 1 isoform C precursor

    See proteins identical to NP_001106272.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (C) has multiple differences in the coding region but maintains the reading frame, compared to variant A. This variant encodes isoform C, also known as NaCa7 or NCX1.7, which is 13 aa shorter than isoform A.
    Source sequence(s)
    AC007254, AF128524, AK291696
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4960
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:796949
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  3. NM_001112802.1NP_001106273.1  sodium/calcium exchanger 1 isoform D precursor

    See proteins identical to NP_001106273.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (D) has multiple differences in the coding region but maintains the reading frame, compared to variant A. This variant encodes isoform D, also known as NaCa3, NCX1.3, or the kidney isoform, which is 36 aa shorter than isoform A.
    Source sequence(s)
    AC007254, AK291696
    Consensus CDS
    CCDS46264.1
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4937
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:773926
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  4. NM_001252624.1NP_001239553.1  sodium/calcium exchanger 1 isoform E precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (E) has multiple differences in the coding region but maintains the reading frame, compared to variant A. This variant encodes isoform E, which is 8 aa shorter than isoform A.
    Source sequence(s)
    AC007254, AC007281, AF108388, AF115505, AF128524
    Consensus CDS
    CCDS59430.1
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4965
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:801954
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  5. NM_021097.2NP_066920.1  sodium/calcium exchanger 1 isoform A precursor

    See proteins identical to NP_066920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (A) represents the longest transcript and encodes the longest isoform (A), also known as NaCa1 or NCX1.1.
    Source sequence(s)
    AC007254, M91368
    Consensus CDS
    CCDS1806.1
    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    40112146..40512476
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712083.1XP_006712146.1  

    See proteins identical to XP_006712146.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  2. XM_006712082.1XP_006712145.1  

    See proteins identical to XP_006712145.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  3. XM_006712085.1XP_006712148.1  

    See proteins identical to XP_006712148.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  4. XM_005264514.1XP_005264571.1  

    See proteins identical to XP_005264571.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4937
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:773926
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  5. XM_006712081.1XP_006712144.1  

    See proteins identical to XP_006712144.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  6. XM_006712084.1XP_006712147.1  

    See proteins identical to XP_006712147.1

    UniProtKB/Swiss-Prot
    P32418
    Conserved Domains (4) summary
    smart00237
    Location:537627
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:4973
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:809962
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:406496
    Calx-beta; Calx-beta domain
  7. XM_005264513.1XP_005264570.1  

    Conserved Domains (4) summary
    smart00237
    Location:567657
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:34967
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:803956
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:436526
    Calx-beta; Calx-beta domain
  8. XM_005264512.1XP_005264569.1  

    Conserved Domains (4) summary
    smart00237
    Location:567657
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:341003
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:839992
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:436526
    Calx-beta; Calx-beta domain
  9. XM_006712080.1XP_006712143.1  

    Conserved Domains (4) summary
    smart00237
    Location:560650
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    TIGR00845
    Location:27996
    caca; sodium/calcium exchanger 1
    pfam01699
    Location:832985
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:429519
    Calx-beta; Calx-beta domain
  10. XM_006712086.1XP_006712149.1  

    Conserved Domains (3) summary
    smart00237
    Location:567631
    Calx_beta; Domains in Na-Ca exchangers and integrin-beta4
    pfam01699
    Location:120279
    Na_Ca_ex; Sodium/calcium exchanger protein
    pfam03160
    Location:436526
    Calx-beta; Calx-beta domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    40269776..40669965
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    40078719..40478536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)