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NME1-NME2 NME1-NME2 readthrough [ Homo sapiens (human) ]

Gene ID: 654364, updated on 8-May-2016
Official Symbol
NME1-NME2provided by HGNC
Official Full Name
NME1-NME2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33531
See related
Ensembl:ENSG00000011052 Vega:OTTHUMG00000137475
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NMELV; NM23-LV
Summary
This locus represents naturally occurring read-through transcription between the neighboring NME1 and NME2 genes. The significance of this read-through transcription and the function of the resulting protein product have not yet been determined. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Orthologs
Location:
17q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (51153536..51171744)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (49230897..49249105)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371826 Neighboring gene sperm associated antigen 9 Neighboring gene uncharacterized LOC105371827 Neighboring gene NME/NM23 nucleoside diphosphate kinase 1 Neighboring gene NME/NM23 nucleoside diphosphate kinase 2 Neighboring gene mbt domain containing 1 Neighboring gene UTP18, small subunit processome component

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough NME1-NME2

Included genes: NME1, NME2

Homology

Clone Names

  • FLJ93990
Preferred Names
NME1-NME2 protein
Names
NME1-NME2 readthrough transcript
NP_001018146.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018136.2NP_001018146.1  NME1-NME2 protein

    See identical proteins and their annotated locations for NP_001018146.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript but encodes the supported protein.
    Source sequence(s)
    AC005839, BC133029, DQ109675
    Consensus CDS
    CCDS32682.1
    UniProtKB/Swiss-Prot
    P22392
    Related
    ENSP00000376889, OTTHUMP00000174725, ENST00000393193, OTTHUMT00000268664
    Conserved Domains (3) summary
    smart00562
    Location:5114
    NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates
    cd04413
    Location:120249
    NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
    pfam00334
    Location:120254
    NDK; Nucleoside diphosphate kinase

RNA

  1. NR_037149.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional internal exon in the 5' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with the translation of the longest ORF; translation of the upstream ORF may render the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC005839, BC107894, DQ109675
    Related
    ENST00000555572, OTTHUMT00000268665

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    51153536..51171744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    49295533..49313740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)