My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    SLC8A2 solute carrier family 8 (sodium/calcium exchanger), member 2 [ Homo sapiens ]

    Gene ID: 6543, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    SLC8A2provided by HGNC
    Official Full Name
    solute carrier family 8 (sodium/calcium exchanger), member 2provided by HGNC
    Primary source
    HGNC:11069
    See related
    Ensembl:ENSG00000118160; HPRD:15990; MIM:601901
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCX2
    Help top of page

    Genomic context

    Location :
    19q13.3
    Sequence :
    Chromosome: 19; NC_000019.9 (47931279..47975307, complement)
    See SLC8A2 in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene Meis homeobox 3 Neighboring gene uncharacterized LOC100505681 Neighboring gene kaptin (actin binding protein) Neighboring gene N-ethylmaleimide-sensitive factor attachment protein, alpha

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. Sathish V, et al. PLoS One, 2011. PMID 21858195.
    2. High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. Sokolow S, et al. Cell Calcium, 2011 Apr. PMID 21382638.
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086.
    4. Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas. Qu M, et al. Neuropathol Appl Neurobiol, 2010 Apr. PMID 20132488.
    5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Talmud PJ, et al. Am J Hum Genet, 2009 Nov. PMID 19913121.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Data suggest that NCX-mediated Ca(2+) fluxes normally exist in human ASM (potentially contributing to rapid Ca(2+) fluxes), and contribute to enhanced [Ca(2+)](i) regulation in airway inflammation.
      Title: Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle.
    2. Results demonstrate a selective regulation of NCX1, NCX2 and NCX3 isoforms in Alzheimer's disease cortex, specifically in terminals containing amyloid-beta.
      Title: High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease.
    3. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    5. The aim of this study was to investigate if NCX2 might be a tumour suppressor gene involved in glioma. Results indicate that DNA methylation may play a key role in the transcriptional silencing of NCX2.
      Title: Molecular genetic and epigenetic analysis of NCX2/SLC8A2 at 19q13.3 in human gliomas.
    6. plasma membrane Na+/Ca2+ exchangers have inhibitory interactions with the 14-3-3 proteins
      Title: Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins.
    Submit: New GeneRIF Correction
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9UPR5 P16298 PPP3CB    HPRD  PubMed  
    Q9UPR5 P31946 YWHAB    HPRD  PubMed  
    Q9UPR5 P62258 YWHAE    HPRD  PubMed  
    Q9UPR5 P27348 YWHAQ    HPRD  PubMed  
    Q9UPR5 P63104 YWHAZ    HPRD  PubMed  
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Calcium signaling pathway, organism-specific biosystem (from KEGG)
      Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Calcium signaling pathway, conserved biosystem (from KEGG)
      Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Platelet calcium homeostasis, organism-specific biosystem (from REACTOME)
      Platelet calcium homeostasis, organism-specific biosystemCa2+ homeostasis is controlled by processes that elevate or counter the elevation of cytosolic Ca2+. During steady state conditions, cytoplasmic Ca2+ is reduced by the accumulation of Ca2+ in intrac...
    • Platelet homeostasis, organism-specific biosystem (from REACTOME)
      Platelet homeostasis, organism-specific biosystemUnder normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhesion and activation, suppresses coagulation, enhances fibrin cleavage and is anti-inflammatory in charact...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Reduction of cytosolic Ca++ levels, organism-specific biosystem (from REACTOME)
      Reduction of cytosolic Ca++ levels, organism-specific biosystemDuring steady state conditions, cytoplasmic [Ca2+] is reduced by the accumulation of Ca2+ in intracellular stores and Ca2+ extrusion.
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Sodium/Calcium exchangers, organism-specific biosystem (from REACTOME)
      Sodium/Calcium exchangers, organism-specific biosystemCalcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracell...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystem (from REACTOME)
      Transport of inorganic cations/anions and amino acids/oligopeptides, organism-specific biosystemTeleologically, one might argue that inorganic cation and anion transport would be evolutionarily among the oldest transport functions. Eight families comprise the group that transports exclusively i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium:sodium antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    calcium ion transport into cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    ion transport TAS
    Traceable Author Statement
    more info
    		  
    response to vitamin D IEA
    Inferred from Electronic Annotation
    more info
    		  
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    telencephalon development IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    neuronal cell body IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    sodium/calcium exchanger 2
    Names
    sodium/calcium exchanger 2
    sodium-calcium exchanger 2
    Na(+)/Ca(2+)-exchange protein 2
    Na+/Ca2+-exchanging protein Nac2
    solute carrier family 8 member 2
    solute carrier family 8 (sodium-calcium exchanger), member 2
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015063.2 → NP_055878.1  sodium/calcium exchanger 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AB029010, AC073548, DC401065
      Consensus CDS
      CCDS33065.1
      UniProtKB/Swiss-Prot
      Q9UPR5
      Related
      ENSP00000236877, ENST00000236877
      Conserved Domains (3) summary
      pfam01699
      Location:84 – 243
      Blast Score: 241
      Na_Ca_ex; Sodium/calcium exchanger protein
      cl02522
      Location:522 – 612
      Blast Score: 312
      Calx-beta; Calx-beta domain
      TIGR00845
      Location:34 – 921
      Blast Score: 3843
      caca; sodium/calcium exchanger 1

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      47931279..47975307, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      44359692..44403467, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC073548.5 (73495..117337) None
    genomic CH471126.1 EAW57484.1
      EAW57485.1
      EAW57486.1
    mRNA AB029010.1 BAA83039.1
    mRNA AK293457.1 BAG56952.1
    mRNA AK293836.1 BAG57237.1
    mRNA AK293860.1 BAG57255.1
    mRNA AK302552.1 BAG63821.1
    mRNA AL512764.1 CAC21681.1
    mRNA DC401065.1 None
    other-genetic BC167838.1 AAI67838.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H021 GenPept UniProtKB/TrEMBL:Q9H021
    Q9UPR5.2 GenPept UniProtKB/Swiss-Prot:Q9UPR5
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...