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Csnk1g2 casein kinase 1, gamma 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65278, updated on 11-Apr-2024

Summary

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Official Symbol
Csnk1g2provided by RGD
Official Full Name
casein kinase 1, gamma 2provided by RGD
Primary source
RGD:621407
See related
Ensembl:ENSRNOG00000018529 AllianceGenome:RGD:621407
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be located in cell cortex. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 166.6), Thymus (RPKM 138.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Csnk1g2 in Genome Data Viewer
Location:
7q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9727430..9746341, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9076739..9095082, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11944957..11963268, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene MAPK interacting serine/threonine kinase 2 Neighboring gene BTB domain containing 2 Neighboring gene secretory carrier membrane protein 4 Neighboring gene large ribosomal subunit protein eL31-like Neighboring gene adenosine deaminase, tRNA-specific 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. Zhai L, et al. J Biol Chem, 1995 May 26. PMID 7759525
  2. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Chia R, et al. Nat Commun, 2014 Dec 15. PMID 25500533, Free PMC Article
  3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
casein kinase I isoform gamma-2; casein kinase I
Names
CKI-gamma 2
NP_001029042.1
NP_075590.2
XP_006241063.1
XP_006241065.1
XP_008763352.1
XP_038935799.1
XP_038935800.1
XP_063120298.1
XP_063120299.1
XP_063120300.1
XP_063120301.1
XP_063120302.1
XP_063120303.1
XP_063120304.1
XP_063120305.1
XP_063120306.1
XP_063120307.1
XP_063120308.1
XP_063120309.1
XP_063120310.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033870.1 → NP_001029042.1  casein kinase I isoform gamma-2 isoform 1

    See identical proteins and their annotated locations for NP_001029042.1

    Status: VALIDATED

    Source sequence(s)
    BC072533
    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5
    Related
    ENSRNOP00000072196.1, ENSRNOT00000080342.2
    Conserved Domains (2) summary
    cd14126
    Location:45 → 332
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:332 → 385
    CK1gamma_C; Casein kinase 1 gamma C terminal

  2. NM_023102.2 → NP_075590.2  casein kinase I isoform gamma-2 isoform 2

    See identical proteins and their annotated locations for NP_075590.2

    Status: VALIDATED

    Source sequence(s)
    BC072533, U22297
    UniProtKB/TrEMBL
    A6K8I3
    Conserved Domains (2) summary
    cd14126
    Location:45 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 384
    CK1gamma_C; Casein kinase 1 gamma C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9727430..9746341 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063264233.1 → XP_063120303.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  2. XM_006241001.5 → XP_006241063.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_006241063.1

    UniProtKB/TrEMBL
    A0A0H2UHQ2, A6K8I6
    Related
    ENSRNOP00000025266.6
    Conserved Domains (3) summary
    COG0515
    Location:45 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:45 → 358
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:358 → 400
    CK1gamma_C; Casein kinase 1 gamma C terminal

  3. XM_008765130.4 → XP_008763352.1  casein kinase I isoform X1

    See identical proteins and their annotated locations for XP_008763352.1

    UniProtKB/TrEMBL
    A0A0H2UHQ2, A6K8I6
    Conserved Domains (3) summary
    COG0515
    Location:45 → 355
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:45 → 358
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:358 → 400
    CK1gamma_C; Casein kinase 1 gamma C terminal

  4. XM_039079871.2 → XP_038935799.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    A6K8I3
    Conserved Domains (2) summary
    cd14126
    Location:45 → 331
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:331 → 384
    CK1gamma_C; Casein kinase 1 gamma C terminal

  5. XM_063264228.1 → XP_063120298.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  6. XM_063264230.1 → XP_063120300.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  7. XM_063264232.1 → XP_063120302.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  8. XM_063264235.1 → XP_063120305.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    A6K8I3

  9. XM_063264229.1 → XP_063120299.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  10. XM_063264236.1 → XP_063120306.1  casein kinase I isoform X3

    UniProtKB/TrEMBL
    A6K8I3

  11. XM_063264234.1 → XP_063120304.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  12. XM_063264231.1 → XP_063120301.1  casein kinase I isoform X2

    UniProtKB/Swiss-Prot
    Q62762, Q6IMY5

  13. XM_063264240.1 → XP_063120310.1  casein kinase I isoform X6

  14. XM_039079872.2 → XP_038935800.1  casein kinase I isoform X6

    Conserved Domains (2) summary
    cd14126
    Location:16 → 283
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:283 → 336
    CK1gamma_C; Casein kinase 1 gamma C terminal

  15. XM_063264239.1 → XP_063120309.1  casein kinase I isoform X5

  16. XM_063264238.1 → XP_063120308.1  casein kinase I isoform X5

  17. XM_063264237.1 → XP_063120307.1  casein kinase I isoform X4

  18. XM_006241003.4 → XP_006241065.1  casein kinase I isoform X4

    Conserved Domains (3) summary
    COG0515
    Location:21 → 281
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    cd14126
    Location:16 → 284
    STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
    pfam12605
    Location:284 → 326
    CK1gamma_C; Casein kinase 1 gamma C terminal

RNA

  1. XR_593259.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62762.2 GenPept UniProtKB/Swiss-Prot:Q62762

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