WNK2 WNK lysine deficient protein kinase 2 [Homo sapiens] - Gene

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Summary

Official Symbol: WNK2provided by HGNC
Official Full Name: WNK lysine deficient protein kinase 2provided by HGNC
Primary source: HGNC:14542
Locus tag: RP11-165J3.2
See related: Ensembl:ENSG00000165238; HPRD:06951; MIM:606249; Vega:OTTHUMG00000020247
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13; KIAA1760
Summary: The protein encoded by this gene is a cytoplasmic serine-threonine kinase that contains cysteine in place of the lysine found at the conserved ATP-binding location in subdomain II of protein kinases. Since this protein does have kinase activity, it is possible that another lysine in the kinase subdomain I can substitute for the missing conserved lysine. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 9q22.3

Sequence :: Chromosome: 9; NC_000009.11 (95947212..96082854)

See WNK2 in Epigenomics, MapViewer

Chromosome 9 - NC_000009.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

a role for WNK2 in the regulation of CCCs in the mammalian brain, with implications for both cell volume regulation and/or GABAergic signaling.
Title: WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Observational study of gene-disease association. (HuGE Navigator)
Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
Title: Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
WNK2 controls a RhoA-mediated cross-talk mechanism that regulates the efficiency with which MEK1 can activate ERK1/2 upon growth factor stimulation.
Title: WNK2 modulates MEK1 activity through the Rho GTPase pathway.
epigenetic silencing, occasional deletion and point mutation, and functional assessment suggest that aberrations of WNK2 may contribute to unregulated tumor cell growth
Title: Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth.
WNK2 is involved in the modulation of growth factor-induced cancer cell proliferation through the MEK1/ERK1/2 pathway.
Title: Protein kinase WNK2 inhibits cell proliferation by negatively modulating the activation of MEK1/ERK1/2.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q9Y3S1	P54253	ATXN1	HPRD	PubMed
BioGRID:122423	BioGRID:122403	WNK1	BioGRID	PubMed	Two-hybrid
BioGRID:122423	BioGRID:113366	YWHAZ	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	ISS Inferred from Sequence or Structural Similarity more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
intracellular protein kinase cascade	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of ERK1 and ERK2 cascade	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of sodium ion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info
regulation of ion homeostasis	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase WNK2

Names: serine/threonine-protein kinase WNK2; antigen NY-CO-43; protein kinase with no lysine 2; protein kinase lysine-deficient 2; protein kinase, lysine deficient 2; serologically defined colon cancer antigen 43; mitogen-activated protein kinase kinase kinase

NP_006639.3

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006648.3 → NP_006639.3 serine/threonine-protein kinase WNK2

Status: REVIEWED

Source sequence(s)

AB051547, AJ242724, AK000694

UniProtKB/TrEMBL

F8W9F9

UniProtKB/Swiss-Prot

Q9Y3S1

Related

ENSP00000378860, ENST00000395477

Conserved Domains (3) summary

cd00180
Location:201 – 389
Blast Score: 546

PKc; Catalytic domain of Protein Kinases

smart00220
Location:200 – 453
Blast Score: 561

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12202
Location:474 – 511
Blast Score: 181

OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000009.11 Reference GRCh37.p5 Primary Assembly

Range

95947212..96082854

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000141.1 Alternate HuRef

Range

65623639..65760276

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL354991.11	CAI14449.3
		CAI14450.2
		CAO03638.1
		CAO03639.1
		CAO03640.1
genomic	AL354991.11	CAI14449.3
		CAI14450.2
		CAO03638.1
		CAO03639.1
		CAO03640.1
genomic	AL390760.25	CAH73069.3
		CAH73070.2
		CAO03646.1
		CAO03647.1
		CAO03648.1
genomic	AL583839.12	CAI12344.3
		CAI12345.2
		CAO03350.1
		CAO03351.1
genomic	AL583839.12	CAI12344.3
		CAI12345.2
		CAO03350.1
		CAO03351.1
genomic	CH471089.1	EAW62857.1
		EAW62858.1
		EAW62859.1
		EAW62860.1
mRNA	AB044546.1	BAB18648.1
mRNA	AB051547.2	BAB21851.2
mRNA	AF039702.1	AAC18051.1
mRNA	AJ242724.4	CAB44308.5
mRNA	AK000694.1	None
mRNA	AK093910.1	None
mRNA	AK096968.1	None
mRNA	AK124314.1	None
mRNA	AK310390.1	None
mRNA	BC037965.1	AAH37965.1