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WNK4 WNK lysine deficient protein kinase 4 [ Homo sapiens (human) ]

Gene ID: 65266, updated on 12-Apr-2014
Official Symbol
WNK4provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 4provided by HGNC
Primary source
HGNC:14544
See related
Ensembl:ENSG00000126562; HPRD:03505; MIM:601844; Vega:OTTHUMG00000180650
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PHA2B; PRKWNK4
Summary
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009]
Location :
17q21-q22
Sequence :
Chromosome: 17; NC_000017.11 (42780614..42797066)
See WNK4 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RAMP2 antisense RNA 1 Neighboring gene receptor (G protein-coupled) activity modifying protein 2 Neighboring gene vacuolar protein sorting 25 homolog (S. cerevisiae) Neighboring gene cytochrome c oxidase assembly factor 3 Neighboring gene cyclin N-terminal domain containing 1 Neighboring gene beclin 1, autophagy related Neighboring gene microRNA 6781

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
chloride transport IEA
Inferred from Electronic Annotation
more info
 
distal tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 
ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
protein localization IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cellular process ISS
Inferred from Sequence or Structural Similarity
more info
 
renal sodium ion absorption IMP
Inferred from Mutant Phenotype
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
tight junction ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
serine/threonine-protein kinase WNK4
Names
serine/threonine-protein kinase WNK4
protein kinase with no lysine 4
protein kinase lysine-deficient 4
NP_115763.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016227.1 RefSeqGene

    Range
    5001..21436
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_032387.4NP_115763.2  serine/threonine-protein kinase WNK4

    See proteins identical to NP_115763.2

    Status: REVIEWED

    Source sequence(s)
    BC136664, BM683764, CA388932
    Consensus CDS
    CCDS11439.1
    UniProtKB/TrEMBL
    B0LPI0
    UniProtKB/Swiss-Prot
    Q96J92
    Related
    ENSP00000246914, OTTHUMP00000264871, ENST00000246914, OTTHUMT00000452389
    Conserved Domains (4) summary
    PTZ00249
    Location:9831108
    Blast Score: 97
    PTZ00249; variable surface protein Vir28; Provisional
    smart00220
    Location:179432
    Blast Score: 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:453489
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl09925
    Location:180432
    Blast Score: 561
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11

    Range
    42780614..42797066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257595.2XP_005257652.1  

    Conserved Domains (4) summary
    PTZ00249
    Location:9831108
    Blast Score: 96
    PTZ00249; variable surface protein Vir28; Provisional
    smart00220
    Location:179432
    Blast Score: 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:453489
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl09925
    Location:180432
    Blast Score: 561
    PKc_like; Protein Kinases, catalytic domain
  2. XM_005257597.2XP_005257654.1  

    Conserved Domains (4) summary
    PTZ00249
    Location:9831108
    Blast Score: 96
    PTZ00249; variable surface protein Vir28; Provisional
    smart00220
    Location:179432
    Blast Score: 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:453489
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl09925
    Location:180432
    Blast Score: 561
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005257596.1XP_005257653.1  

    Conserved Domains (4) summary
    PTZ00249
    Location:9821107
    Blast Score: 97
    PTZ00249; variable surface protein Vir28; Provisional
    smart00220
    Location:179432
    Blast Score: 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:453489
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl09925
    Location:180432
    Blast Score: 561
    PKc_like; Protein Kinases, catalytic domain
  4. XM_006722020.1XP_006722083.1  

    Conserved Domains (4) summary
    PTZ00249
    Location:9371062
    Blast Score: 96
    PTZ00249; variable surface protein Vir28; Provisional
    smart00220
    Location:179432
    Blast Score: 588
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:453489
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
    cl09925
    Location:180432
    Blast Score: 561
    PKc_like; Protein Kinases, catalytic domain
  5. XM_005257598.2XP_005257655.1  

    Conserved Domains (2) summary
    PTZ00249
    Location:675800
    Blast Score: 94
    PTZ00249; variable surface protein Vir28; Provisional
    pfam12202
    Location:145181
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  6. XM_006722021.1XP_006722084.1  

    Conserved Domains (2) summary
    PTZ00249
    Location:647772
    Blast Score: 94
    PTZ00249; variable surface protein Vir28; Provisional
    pfam12202
    Location:117153
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  7. XM_006722022.1XP_006722085.1  

    Conserved Domains (2) summary
    PTZ00249
    Location:647772
    Blast Score: 95
    PTZ00249; variable surface protein Vir28; Provisional
    pfam12202
    Location:117153
    Blast Score: 146
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    36697144..36713472
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    41168235..41184670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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