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    UBE2Z ubiquitin-conjugating enzyme E2Z [ Homo sapiens ]

    Gene ID: 65264, updated on 8-Jan-2012
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    Summary

    Official Symbol
    UBE2Zprovided by HGNC
    Official Full Name
    ubiquitin-conjugating enzyme E2Zprovided by HGNC
    Primary source
    HGNC:25847
    Locus tag
    HOYS7
    See related
    Ensembl:ENSG00000159202; HPRD:08589; MIM:611362; Vega:OTTHUMG00000150521
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    USE1; HOYS7
    Summary
    Modification of proteins with ubiquitin (UBB; MIM 191339) or ubiquitin-like proteins controls many signaling networks and requires a ubiquitin activating enzyme (E1), a ubiquitin conjugating enzyme (E2), and a ubiquitin protein ligase (E3). UBE2Z is an E2 enzyme (Jin et al., 2007 [PubMed 17597759]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    17q21.32
    Sequence :
    Chromosome: 17; NC_000017.10 (46985731..47006422)
    See UBE2Z in Epigenomics, MapViewer

    Chromosome 17 - NC_000017.10Genomic Context describing neighboring genes Neighboring gene ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9) Neighboring gene ribosomal protein L37 pseudogene Neighboring gene SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) Neighboring gene gastric inhibitory polypeptide

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Alternative ubiquitin activation/conjugation cascades interact with N-end rule ubiquitin ligases to control degradation of RGS proteins. Lee PC, et al. Mol Cell, 2011 Aug 5. PMID 21816346.
    2. Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Schunkert H, et al. Nat Genet, 2011 Mar 6. PMID 21378990.
    3. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. van Wijk SJ, et al. Mol Syst Biol, 2009. PMID 19690564.
    4. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Markson G, et al. Genome Res, 2009 Oct. PMID 19549727.
    5. Toward a confocal subcellular atlas of the human proteome. Barbe L, et al. Mol Cell Proteomics, 2008 Mar. PMID 18029348.

    See all (14) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. UBE2Z was widely expressed in human tissues and is located on chromosome 17q21.
      Title: Cloning and characterization of a gene encoding the human putative ubiquitin conjugating enzyme E2Z (UBE2Z).
    2. In tissue culture cells, Uba6 is required for charging a previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is required for charging the cell-cycle E2s Cdc34A and Cdc34B
      Title: Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9H832 O00238 BMPR1B    HPRD  PubMed  
    Q9H832 P06858 LPL    HPRD  PubMed  
    Q9H832 Q9H8W4 PLEKHF2    HPRD  PubMed  
    Q9H832 Q15797 SMAD1    HPRD  PubMed  
    Q9H832 Q13485 SMAD4    HPRD  PubMed  
    Q9H832 Q9HD15 SRA1    HPRD  PubMed  
    Q9H832 P36897 TGFBR1    HPRD  PubMed  
    BioGRID:122419 BioGRID:115021 DZIP3    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:112480 HLTF    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:128798 LNX2    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:110205 LPL    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:110358 MDM2    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:122791 PLEKHF2    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:111848 RAPSN    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:113601 RNF103    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:120928 RNF130    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:116401 RNF139    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:129106 RNF144B    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:121553 RNF150    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:125465 RNF166    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:115488 RNF41    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:111975 RNF5    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:124085 SYVN1    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:115581 TRAIP    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:111919 TRIM27    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:123129 TRIM46    BioGRID  PubMed Two-hybrid 
    BioGRID:122419 BioGRID:128238 UBR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:122419 BioGRID:116896 UBR2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:122419 BioGRID:126237 UBR3    BioGRID  PubMed Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

    Clone Names

    • FLJ13855

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    acid-amino acid ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    ubiquitin-protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    ubiquitin-conjugating enzyme E2 Z
    Names
    ubiquitin-conjugating enzyme E2 Z
    UBA6-specific enzyme E2
    ubiquitin-protein ligase Z
    ubiquitin carrier protein Z
    uba6-specific E2 conjugating enzyme 1
    NP_075567.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023079.4 → NP_075567.2  ubiquitin-conjugating enzyme E2 Z

      Status: VALIDATED

      Source sequence(s)
      AA845421, AC091133, AK122770, AL713782, BC015890
      Consensus CDS
      CCDS11540.2
      UniProtKB/Swiss-Prot
      Q9H832
      Related
      ENSP00000354201, OTTHUMP00000197726, ENST00000360943, OTTHUMT00000318724
      Conserved Domains (1) summary
      cd00195
      Location:103 – 203
      Blast Score: 260
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000017.10 Reference GRCh37.p5 Primary Assembly

      Range
      46985731..47006422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000149.1 Alternate HuRef

      Range
      42353370..42374100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC091133.11 (111711..132397) None
    genomic CH471109.2 EAW94701.1
      EAW94702.1
      EAW94703.1
      EAW94704.1
    mRNA AA843379.1 None
    mRNA AA845421.1 None
    mRNA AB025426.1 BAB87810.1
    mRNA AK023917.1 BAB14724.1
    mRNA AK024030.1 BAB14789.1
    mRNA AK091644.1 None
    mRNA AK122770.1 None
    mRNA AK130303.1 None
    mRNA AK296865.1 BAG59428.1
    mRNA AL713782.1 CAD28542.1
    mRNA BC015169.1 AAH15169.2
    mRNA BC015890.1 AAH15890.1
    mRNA CR457322.1 CAG33603.1
    mRNA DA928380.1 None
    mRNA EF623992.1 ABR25252.1
    Protein Accession Links
    GenePept Link UniProtKB Link
    Q9H832.2 GenPept UniProtKB/Swiss-Prot:Q9H832
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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      Supplemental Content

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