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SLC5A2 solute carrier family 5 member 2 [ Homo sapiens (human) ]

Gene ID: 6524, updated on 22-May-2016
Official Symbol
SLC5A2provided by HGNC
Official Full Name
solute carrier family 5 member 2provided by HGNC
Primary source
HGNC:HGNC:11037
See related
Ensembl:ENSG00000140675 HPRD:08919; MIM:182381; Vega:OTTHUMG00000176620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGLT2
Summary
This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
Orthologs
Location:
16p11.2
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (31482535..31490770)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31494439..31502091)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 5 Neighboring gene transforming growth factor beta 1 induced transcript 1 Neighboring gene uncharacterized LOC105371171 Neighboring gene chromosome 16 open reading frame 58 Neighboring gene uncharacterized LOC101928829 Neighboring gene alpha hemoglobin stabilizing protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Hexose transport, organism-specific biosystem (from REACTOME)
    Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
  • Inositol transporters, organism-specific biosystem (from REACTOME)
    Inositol transporters, organism-specific biosystemMyo-Inositol is a neutral cyclic polyol, abundant in mammalian tissues. It plays important roles; it is a precursor to phosphatidylinositols (PtdIns) and to the inositol phosphates (IP), which serve ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
  • Na+-dependent glucose transporters, organism-specific biosystem (from REACTOME)
    Na+-dependent glucose transporters, organism-specific biosystemTwo gene families are responsible for glucose transport in humans. SLC2 (encoding GLUTs) and SLC5 (encoding SGLTs) families mediate glucose absorption in the small intestine, glucose reabsorption in ...
  • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
    SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
  • Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystem (from REACTOME)
    Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds, organism-specific biosystemHexoses like glucose, galactose and fructose serve as basic fuel molecules for eukaryotic cells. Indeed, glucose is the main energy source for mammalian cells. These sugars are unable to diffuse acro...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glucose:sodium symporter activity TAS
Traceable Author Statement
more info
 
low-affinity glucose:sodium symporter activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
carbohydrate metabolic process TAS
Traceable Author Statement
more info
PubMed 
glucose transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
brush border membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
sodium/glucose cotransporter 2
Names
Na(+)/glucose cotransporter 2
low affinity sodium-glucose cotransporter
solute carrier family 5 (sodium/glucose cotransporter), member 2
solute carrier family 5 (sodium/glucose transporter), member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012892.1 RefSeqGene

    Range
    5001..12653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_003041.3NP_003032.1  sodium/glucose cotransporter 2

    See identical proteins and their annotated locations for NP_003032.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer, protein-coding transcript.
    Source sequence(s)
    AI222550, M95549
    Consensus CDS
    CCDS10714.1
    UniProtKB/Swiss-Prot
    P31639
    Related
    ENSP00000327943, OTTHUMP00000163298, ENST00000330498, OTTHUMT00000255627
    Conserved Domains (1) summary
    cd11487
    Location:24672
    SLC5sbd_SGLT2; Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain

RNA

  1. NR_130783.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AI222550, BC131542
    Related
    ENST00000419665, OTTHUMT00000432874

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    31482535..31490770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006721073.2XP_006721136.2  

    Conserved Domains (1) summary
    cl00456
    Location:31434
    SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
  2. XM_006721072.2XP_006721135.2  

    Conserved Domains (1) summary
    cd11487
    Location:31705
    SLC5sbd_SGLT2; Na(+)/glucose cotransporter SGLT2 and related proteins; solute-binding domain

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    32813088..32820740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)