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    NADK NAD kinase [ Homo sapiens ]

    Gene ID: 65220, updated on 11-May-2012
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    Summary

    Official Symbol
    NADKprovided by HGNC
    Official Full Name
    NAD kinaseprovided by HGNC
    Primary source
    HGNC:29831
    Locus tag
    RP1-283E3.6
    See related
    Ensembl:ENSG00000008130; HPRD:16907; MIM:611616; Vega:OTTHUMG00000000942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    dJ283E3.1; RP1-283E3.6; MGC1900; FLJ13052; FLJ37724; FLJ54695; FLJ77769; FLJ78247; FLJ78307; DKFZp686L22239
    Summary
    NADK catalyzes the transfer of a phosphate group from ATP to NAD to generate NADP, which in its reduced form acts as an electron donor for biosynthetic reactions (Lerner et al., 2001 [PubMed 11594753]).[supplied by OMIM, Mar 2008]
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    Genomic context

    Location :
    1p36.33
    Sequence :
    Chromosome: 1; NC_000001.10 (1682671..1711508, complement)
    See NADK in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene cyclin-dependent kinase 11A Neighboring gene ribosomal protein S7 pseudogene Neighboring gene solute carrier family 35, member E2 Neighboring gene guanine nucleotide binding protein (G protein), beta polypeptide 1 Neighboring gene calmodulin-like 6

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    2. NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme. Ohashi K, et al. Mol Cell Biochem, 2011 Sep. PMID 21526340.
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    4. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. Wang J, et al. J Proteome Res, 2008 Sep. PMID 18624398.
    5. NAD kinase levels control the NADPH concentration in human cells. Pollak N, et al. J Biol Chem, 2007 Nov 16. PMID 17855339.

    See all (21) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Using purified human NAD kinase, we revealed a sigmoidal kinetic behavior toward ATP and the inhibitory effects of NADPH and NADH
      Title: NADPH regulates human NAD kinase, a NADP⁺-biosynthetic enzyme.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. NAD kinase levels control the NADPH concentration in human cells
      Title: NAD kinase levels control the NADPH concentration in human cells.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O95544 P26641 EEF1G    HPRD  PubMed  
    O95544 O76003 GLRX3    HPRD  PubMed  
    O95544 Q8TBB1 LNX1    HPRD  PubMed  
    O95544 O95544 NADK    HPRD  PubMed  
    O95544 NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 NUDT18    HPRD  PubMed  
    BioGRID:122408 BioGRID:108257 EEF1G    BioGRID  PubMed Two-hybrid 
    BioGRID:122408 BioGRID:115793 GLRX3    BioGRID  PubMed Two-hybrid 
    BioGRID:122408 BioGRID:109142 GRB2    BioGRID  PubMed Two-hybrid 
    BioGRID:122408 BioGRID:124219 LNX1    BioGRID  PubMed Two-hybrid 
    BioGRID:122408 BioGRID:122961 NUDT18    BioGRID  PubMed Two-hybrid 
    BioGRID:122408 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122408 BioGRID:113364 YWHAG    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122408 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122408 BioGRID:113366 YWHAZ    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the NADK gene: The NADK gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD+ kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NAD+ kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NAD+ kinase activity TAS
    Traceable Author Statement
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    ATP metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    NAD metabolic process TAS
    Traceable Author Statement
    more info
    		  
    metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    phosphorylation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    vitamin metabolic process TAS
    Traceable Author Statement
    more info
    		  
    water-soluble vitamin metabolic process TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    		  
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    General protein information

    Preferred Names
    NAD kinase
    Names
    NAD kinase
    poly(P)/ATP NAD kinase
    NP_001185922.1
    NP_001185923.1
    NP_001185924.1
    NP_075394.3
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198993.1 → NP_001185922.1  NAD kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform 1.
      Source sequence(s)
      AL031282, BC001709, BC024219, BM842058, CN349189
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      O95544
      UniProtKB/TrEMBL
      Q6PJ22
      Related
      ENSP00000344340, OTTHUMP00000001110, ENST00000341991, OTTHUMT00000002768
      Conserved Domains (1) summary
      cl01255
      Location:98 – 433
      Blast Score: 657
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. NM_001198994.1 → NP_001185923.1  NAD kinase isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and CDS compared to variant 1. The resulting isoform (2) has two additional internal segments, as compared to isoform 1.
      Source sequence(s)
      AF250320, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55562.1
      UniProtKB/Swiss-Prot
      O95544
      UniProtKB/TrEMBL
      Q5QPS4
      UniProtKB/TrEMBL
      Q9H2P2
      Related
      ENSP00000367890, OTTHUMP00000001109, ENST00000378625, OTTHUMT00000002767
      Conserved Domains (1) summary
      cl01255
      Location:202 – 578
      Blast Score: 616
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. NM_001198995.1 → NP_001185924.1  NAD kinase isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks three exons from the 5' end and has an alternate 5' exon compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK296722, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS55561.1
      UniProtKB/TrEMBL
      B7Z434
      UniProtKB/TrEMBL
      F5GXR5
      UniProtKB/Swiss-Prot
      O95544
      Related
      ENSP00000339727, ENST00000342348
      Conserved Domains (1) summary
      cl01255
      Location:66 – 401
      Blast Score: 661
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. NM_023018.4 → NP_075394.3  NAD kinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) and variant 2 encode a predominant isoform (1).
      Source sequence(s)
      AK023114, AL031282, BC001709, BM842058
      Consensus CDS
      CCDS30565.1
      UniProtKB/Swiss-Prot
      O95544
      Related
      ENSP00000341679, OTTHUMP00000001111, ENST00000341426, OTTHUMT00000002769
      Conserved Domains (1) summary
      cl01255
      Location:98 – 433
      Blast Score: 657
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      1682671..1711508, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      958943..988065, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031282.1 CAA20354.1
      CAI20045.1
      CAI20046.1
    genomic CH471183.1 EAW56151.1
      EAW56152.1
      EAW56153.1
      EAW56154.1
      EAW56155.1
    mRNA AF070630.1 None
    mRNA AF250320.1 AAG44568.1
    mRNA AK023114.1 BAB14412.1
    mRNA AK095043.1 None
    mRNA AK290161.1 BAF82850.1
    mRNA AK291599.1 BAF84288.1
    mRNA AK291728.1 BAF84417.1
    mRNA AK296722.1 BAH12420.1
    mRNA AK307645.1 None
    mRNA AY090771.1 AAM01195.1
    mRNA BC001709.1 AAH01709.1
    mRNA BC022063.2 None
    mRNA BC024219.1 AAH24219.1
    mRNA BM842058.1 None
    mRNA BX647173.1 None
    mRNA CN349189.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95544.1 GenPept UniProtKB/Swiss-Prot:O95544
    Q5QPS4 GenPept UniProtKB/TrEMBL:Q5QPS4
    Q5QPS5 GenPept UniProtKB/TrEMBL:Q5QPS5
    Q6PJ22 GenPept UniProtKB/TrEMBL:Q6PJ22
    Q9H2P2 GenPept UniProtKB/TrEMBL:Q9H2P2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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