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WNK1 WNK lysine deficient protein kinase 1 [ Homo sapiens (human) ]

Gene ID: 65125, updated on 19-Jul-2014
Official Symbol
WNK1provided by HGNC
Official Full Name
WNK lysine deficient protein kinase 1provided by HGNC
Primary source
HGNC:14540
See related
Ensembl:ENSG00000060237; HPRD:05570; MIM:605232; Vega:OTTHUMG00000090321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KDP; PSK; p65; HSN2; HSAN2; PRKWNK1; PPP1R167
Summary
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
See WNK1 in Epigenomics, MapViewer
Location:
12p13.3
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 12 NC_000012.12 (752593..911452)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (861759..1020618)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ninjurin 2 Neighboring gene uncharacterized LOC101929432 Neighboring gene RAD52 homolog (S. cerevisiae) Neighboring gene uncharacterized LOC101929449 Neighboring gene ELKS/RAB6-interacting/CAST family member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed
Knockdown of WNK lysine deficient protein kinase 1 (WNK1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Protein Interaction Database

  • EGFR1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGFR1 Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Stimuli-sensing channels, organism-specific biosystem (from REACTOME)
    Stimuli-sensing channels, organism-specific biosystemIon channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et ...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • KIAA0344, MGC163339, MGC163341

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
chloride channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
intracellular signal transduction TAS
Traceable Author Statement
more info
 
ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of pancreatic juice secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
neuron development NAS
Non-traceable Author Statement
more info
PubMed 
peptidyl-threonine phosphorylation TAS
Traceable Author Statement
more info
 
positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase WNK1
Names
serine/threonine-protein kinase WNK1
erythrocyte 65 kDa protein
protein kinase with no lysine 1
prostate-derived sterile 20-like kinase
WNK lysine deficient protein kinase 1 isoform
protein phosphatase 1, regulatory subunit 167
NP_001171914.1
NP_055638.2
NP_061852.3
NP_998820.3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_007984.2 

    Range
    4865..163394
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184985.1NP_001171914.1  serine/threonine-protein kinase WNK1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the dorsal root ganglia and sciatic nerve variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 4, which is longer than isoform 1.
    Source sequence(s)
    AC004765, AC004803
    UniProtKB/Swiss-Prot
    Q9H4A3
    Related
    ENSP00000444465, ENST00000537687
    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. NM_014823.2NP_055638.2  serine/threonine-protein kinase WNK1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses two alternative splice sites and lacks two exons in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
    Consensus CDS
    CCDS53731.1
    UniProtKB/TrEMBL
    A5D8Z4
    UniProtKB/TrEMBL
    F5GWT4
    UniProtKB/Swiss-Prot
    Q9H4A3
    Related
    ENSP00000441972, OTTHUMP00000237889, ENST00000535572, OTTHUMT00000398086
    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. NM_018979.3NP_061852.3  serine/threonine-protein kinase WNK1 isoform 1

    See proteins identical to NP_061852.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the most common isoform (1), as indicated in PubMed ID 18521183.
    Source sequence(s)
    AB002342, AC004765, AC004803, AI074334, AJ296290, BC141881, BX644268, CD629562, DA720959
    Consensus CDS
    CCDS8506.1
    UniProtKB/TrEMBL
    A5D8Z4
    UniProtKB/Swiss-Prot
    Q9H4A3
    Related
    ENSP00000313059, OTTHUMP00000115370, ENST00000315939, OTTHUMT00000206683
    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. NM_213655.4NP_998820.3  serine/threonine-protein kinase WNK1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame compared to variant 1. This variant represents the exon combination of the brain and spinal cord variant described in Figure 2F of PubMed ID 18521183. This variant encodes isoform 3, which is longer than isoform 1.
    Source sequence(s)
    AC004765, AC004803
    UniProtKB/Swiss-Prot
    Q9H4A3
    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12 

    Range
    752593..911452
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253734.1XP_005253791.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  2. XM_005253735.1XP_005253792.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  3. XM_006718999.1XP_006719062.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  4. XM_006719001.1XP_006719064.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  5. XM_006719002.1XP_006719065.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  6. XM_006718998.1XP_006719061.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  7. XM_006719003.1XP_006719066.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  8. XM_006719000.1XP_006719063.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  9. XM_006719004.1XP_006719067.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  10. XM_005253739.1XP_005253796.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  11. XM_005253736.1XP_005253793.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  12. XM_005253740.1XP_005253797.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  13. XM_005253737.1XP_005253794.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  14. XM_005253741.1XP_005253798.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  15. XM_005253738.2XP_005253795.1  

    Conserved Domains (3) summary
    cd00180
    Location:227476
    Blast Score: 553
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:226479
    Blast Score: 605
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    pfam12202
    Location:500537
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal
  16. XM_005253743.2XP_005253800.1  

    Related
    ENSP00000341292
    Conserved Domains (1) summary
    pfam12202
    Location:93130
    Blast Score: 188
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

Alternate HuRef

Genomic

  1. AC_000144.1 

    Range
    714669..871790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 

    Range
    861230..1019755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)