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    RSRC2 arginine/serine-rich coiled-coil 2 [ Homo sapiens (human) ]

    Gene ID: 65117, updated on 5-May-2013
    Official Symbol
    RSRC2provided by HGNC
    Official Full Name
    arginine/serine-rich coiled-coil 2provided by HGNC
    Primary source
    HGNC:30559
    See related
    Ensembl:ENSG00000111011; HPRD:13342; Vega:OTTHUMG00000167572
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Location :
    12q24.31
    Sequence :
    Chromosome: 12; NC_000012.11 (122989190..123011560, complement)
    See RSRC2 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 1 Neighboring gene uncharacterized LOC100507066 Neighboring gene zinc finger, CCHC domain containing 8 Neighboring gene kinetochore associated 1 Neighboring gene hydroxycarboxylic acid receptor 2

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049.
    2. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Rahman S, et al. Mol Cell Biol, 2011 Jul. PMID 21555454.
    3. A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients. Kurehara H, et al. Int J Oncol, 2007 Feb. PMID 17203224.
    4. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. Lim J, et al. Cell, 2006 May 19. PMID 16713569.
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.

    See all (7) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. RSRC2 might play a role in cell proliferation and progression of esophageal cancer
      Title: A novel gene, RSRC2, inhibits cell proliferation and affects survival in esophageal cancer patients.
    Submit: New GeneRIF Correction

    Review eQTL and phenotype association data in this region using PheGenI

    Products Interactant Other Gene Complex Source Pubs Description
    Arginine/serine-rich coiled-coil 2 Q9NRR5 UBQLN4    HPRD  PubMed  
    BioGRID:122398 BioGRID:106848 APP    BioGRID  PubMed Reconstituted Complex 
    BioGRID:122398 BioGRID:116817 JMJD6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122398 BioGRID:121223 UBQLN4    BioGRID  PubMed Two-hybrid 

    Markers

    Genotypes

    Homology

    Clone Names

    • FLJ11021
    Preferred Names
    arginine/serine-rich coiled-coil protein 2
    Names
    arginine/serine-rich coiled-coil protein 2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_023012.5 → NP_075388.2  arginine/serine-rich coiled-coil protein 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the shortest transcript but encodes a functional protein.
      Source sequence(s)
      AB212664, AC127002, DB081070
      Consensus CDS
      CCDS31920.1
      UniProtKB/Swiss-Prot
      Q7L4I2
      Related
      ENSP00000330188, OTTHUMP00000236187, ENST00000331738, OTTHUMT00000395096

    RNA

    1. NR_036434.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) has an additional exon in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AC127002, AK094465, BC008684, DB081070

    2. NR_036435.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an additional exon and an additional segment in the CDS compared to variant 1. The exon includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AC127002, DB081070

    3. NR_036436.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has an additional segment in the CDS compared to variant 1. The segment includes a premature stop codon, so this variant is a nonsense-mediated mRNA decay candidate and does not make a functional protein.
      Source sequence(s)
      AB212664, AC127002, BX647884, DB081070

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      122989190..123011560, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      119950069..119972097, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      122804797..122826836, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198261.2: Suppressed sequence

      Description
      NM_198261.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.

    2. NM_198262.2: Suppressed sequence

      Description
      NM_198262.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    genomic ABBA01060462.1 (10637..32665) None
    genomic AC127002.3 (85488..107844) None
    genomic AMYH01004828.1 (8767..30806) None
    genomic CH471054.1 EAW98327.1
      EAW98328.1
      EAW98329.1
      EAW98330.1
      EAW98331.1
      EAW98332.1
    mRNA AB212664.1 BAE93762.1
    mRNA AF161432.1 AAF28992.1
    mRNA AK001883.1 BAG50986.1
    mRNA AK023985.1 BAB14755.1
    mRNA AK056114.1 None
    mRNA AK056256.1 None
    mRNA AK094465.1 None
    mRNA BC008684.1 AAH08684.2
    mRNA BC067773.1 AAH67773.1
    mRNA BX640711.1 CAE45830.1
    mRNA BX647884.1 None
    mRNA CA442478.1 None
    mRNA DB081070.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L4I2.1 GenPept UniProtKB/Swiss-Prot:Q7L4I2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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