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    CDK15 cyclin-dependent kinase 15 [ Homo sapiens ]

    Gene ID: 65061, updated on 15-May-2012
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    Summary

    Official Symbol
    CDK15provided by HGNC
    Official Full Name
    cyclin-dependent kinase 15provided by HGNC
    Primary source
    HGNC:14434
    See related
    Ensembl:ENSG00000138395; HPRD:12449; Vega:OTTHUMG00000132838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PFTK2; ALS2CR7; PFTAIRE2
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    Genomic context

    Location :
    2q33.2
    Sequence :
    Chromosome: 2; NC_000002.11 (202671198..202758266)
    See CDK15 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) Neighboring gene amyotrophic lateral sclerosis 2 (juvenile) Neighboring gene ribosomal protein S2 pseudogene 16 Neighboring gene uncharacterized LOC100652824 Neighboring gene frizzled family receptor 7

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Cyclin-dependent kinases: a family portrait. Malumbres M, et al. Nat Cell Biol, 2009 Nov. PMID 19884882.
    2. Large-scale mapping of human protein-protein interactions by mass spectrometry. Ewing RM, et al. Mol Syst Biol, 2007. PMID 17353931.
    3. Mammalian cyclin-dependent kinases. Malumbres M, et al. Trends Biochem Sci, 2005 Nov. PMID 16236519.
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (9) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:122381 BioGRID:107452 CDK2    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    cyclin-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    cyclin-dependent kinase 15
    Names
    cyclin-dependent kinase 15
    PFTAIRE protein kinase 2
    cell division protein kinase 15
    serine/threonine protein kinase
    serine/threonine-protein kinase ALS2CR7
    serine/threonine-protein kinase PFTAIRE-2
    amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 7
    amyotrophic lateral sclerosis 2 chromosomal region candidate gene 7 protein
    NP_631897.1
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001261435.1 → NP_001248364.1  cyclin-dependent kinase 15 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AC007242, AC007358, BX647394, DA050598

    2. NM_001261436.1 → NP_001248365.1  cyclin-dependent kinase 15 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region and UTR compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      BC038807, DA050598

    3. NM_139158.2 → NP_631897.1  cyclin-dependent kinase 15 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has an alternate in-frame 5' exon and initiates translation at an upstream AUG compared to variant 1. This results in a shorter protein (isoform 3) with a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AB053308, AC007242, AC007358
      Consensus CDS
      CCDS2350.1
      UniProtKB/Swiss-Prot
      Q96Q40
      Related
      ENSP00000260967, OTTHUMP00000163739, ENST00000260967, OTTHUMT00000256311
      Conserved Domains (2) summary
      cd07870
      Location:46 – 336
      Blast Score: 1541
      STKc_PFTAIRE2; Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase
      PLN00009
      Location:52 – 339
      Blast Score: 784
      PLN00009; cyclin-dependent kinase A; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      202671198..202758266
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      194519404..194607042
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC007242.3 AAX93182.1
    genomic AC007358.2 AAX88914.1
    genomic CH471063.1 EAW70295.1
      EAW70296.1
      EAW70297.1
    mRNA AB053308.1 BAB69017.1
    mRNA AK091710.1 None
    mRNA AK131512.1 BAD18656.1
    mRNA AK292434.1 BAF85123.1
    mRNA AK310050.1 None
    mRNA AX772791.1 CAE06249.1
    mRNA BC038807.1 AAH38807.1
    mRNA BX647394.1 None
    other-genetic EU831751.1 ACE87269.1
    other-genetic EU831752.1 ACE87270.1
    other-genetic EU831827.1 ACE86586.1
    other-genetic EU831828.1 ACE86587.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96Q40.2 GenPept UniProtKB/Swiss-Prot:Q96Q40
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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