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Ppp1r10 protein phosphatase 1, regulatory subunit 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 65045, updated on 11-Apr-2024

Summary

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Official Symbol
Ppp1r10provided by RGD
Official Full Name
protein phosphatase 1, regulatory subunit 10provided by RGD
Primary source
RGD:620079
See related
Ensembl:ENSRNOG00000059268 AllianceGenome:RGD:620079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fb19; Pnuts
Summary
Enables protein phosphatase 1 binding activity and protein phosphatase inhibitor activity. Predicted to be involved in negative regulation of cardiac muscle cell apoptotic process; negative regulation of mitotic DNA damage checkpoint; and positive regulation of telomere maintenance. Located in chromatin. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 132.2), Kidney (RPKM 102.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
20p12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (2827802..2842418, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (2822995..2838125, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (3329677..3344286, complement)

Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene proline rich 3 Neighboring gene ATP binding cassette subfamily F member 1 Neighboring gene microRNA 877 Neighboring gene mitochondrial ribosomal protein S18B Neighboring gene alpha tubulin acetyltransferase 1 Neighboring gene similar to human chromosome 6 open reading frame 136

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Isolation and characterization of PNUTS, a putative protein phosphatase 1 nuclear targeting subunit. Allen PB, et al. J Biol Chem, 1998 Feb 13. PMID 9461602
  2. PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation. Kim YM, et al. J Biol Chem, 2003 Apr 18. PMID 12574161
  3. MicroRNA-34a regulates cardiac ageing and function. Boon RA, et al. Nature, 2013 Mar 7. PMID 23426265
  4. Identification and characterization of a novel human PP1 phosphatase complex. Lee JH, et al. J Biol Chem, 2010 Aug 6. PMID 20516061, Free PMC Article
  5. A quantitative telomeric chromatin isolation protocol identifies different telomeric states. Grolimund L, et al. Nat Commun, 2013. PMID 24270157

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PNUTS has a role in protein kinase A-regulated targeting of PP1 to specific RNA-associated complexes in the nucleus
    Title: PNUTS, a protein phosphatase 1 (PP1) nuclear targeting subunit. Characterization of its PP1- and RNA-binding domains and regulation by phosphorylation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein phosphatase 1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of mitotic DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PTW/PP1 phosphatase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PTW/PP1 phosphatase complex ISO
Inferred from Sequence Orthology
more info
  
part_of PTW/PP1 phosphatase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 1 regulatory subunit 10
Names
MHC class I region proline-rich protein CAT53
phosphatase 1 nuclear targeting subunit
putative protein phosphatase 1 nuclear targeting subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022951.2 → NP_075240.1  serine/threonine-protein phosphatase 1 regulatory subunit 10

    See identical proteins and their annotated locations for NP_075240.1

    Status: VALIDATED

    Source sequence(s)
    BC134805, BP477033, BX883048
    UniProtKB/Swiss-Prot
    O55000, Q6MG09
    UniProtKB/TrEMBL
    A0A0G2K3G9, A4QN30
    Related
    ENSRNOP00000082809.1, ENSRNOT00000088836.3
    Conserved Domains (2) summary
    pfam18044
    Location:842 → 864
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086038.1 Reference GRCr8

    Range
    2827802..2842418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039099055.2 → XP_038954983.1  serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1

    UniProtKB/Swiss-Prot
    O55000, Q6MG09
    UniProtKB/TrEMBL
    A0A0G2K3G9, A4QN30
    Conserved Domains (2) summary
    pfam18044
    Location:842 → 864
    zf-CCCH_4; CCCH-type zinc finger
    cl00146
    Location:102 → 146
    TFIIS_I; N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55000.1 GenPept UniProtKB/Swiss-Prot:O55000

Gene LinkOut

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