My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    SKP1 S-phase kinase-associated protein 1 [ Homo sapiens ]

    Gene ID: 6500, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    SKP1provided by HGNC
    Official Full Name
    S-phase kinase-associated protein 1provided by HGNC
    Primary source
    HGNC:10899
    See related
    Ensembl:ENSG00000113558; HPRD:03255; MIM:601434; Vega:OTTHUMG00000129117
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OCP2; p19A; EMC19; SKP1A; OCP-II; TCEB1L; MGC34403
    Summary
    This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    5q31
    Sequence :
    Chromosome: 5; NC_000005.9 (133492082..133512724, complement)
    See SKP1 in Epigenomics, MapViewer

    Chromosome 5 - NC_000005.9Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 1 Neighboring gene transcription factor 7 (T-cell specific, HMG-box) Neighboring gene protein phosphatase 2, catalytic subunit, alpha isozyme Neighboring gene microRNA 3661 Neighboring gene ribosomal protein S13 pseudogene 6

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Mediator acts upstream of the transcriptional activator Gal4. Ang K, et al. PLoS Biol, 2012 Mar. PMID 22479149.
    2. APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1. Klitzing Cv, et al. PLoS One, 2011. PMID 22205987.
    3. FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas. Duan S, et al. Nature, 2012 Jan 5. PMID 22113614.
    4. NIRF constitutes a nodal point in the cell cycle network and is a candidate tumor suppressor. Mori T, et al. Cell Cycle, 2011 Oct 1. PMID 21952639.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (138) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner
      Title: APC/C(Cdh1)-mediated degradation of the F-box protein NIPA is regulated by its association with Skp1.
    2. SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein
      Title: The SKP1-Cul1-F-box and leucine-rich repeat protein 4 (SCF-FbxL4) ubiquitin ligase regulates lysine demethylase 4A (KDM4A)/Jumonji domain-containing 2A (JMJD2A) protein.
    3. These observations suggest that Skp1 plays an important role in stabilizing the conformation of these F-box proteins, which increases their expression levels and substrate-binding.
      Title: Skp1 stabilizes the conformation of F-box proteins.
    4. Skp1 binding prevented Fbxo7 from contacting CRM1.
      Title: A Competitive binding mechanism between Skp1 and exportin 1 (CRM1) controls the localization of a subset of F-box proteins.
    5. Data demonstrate that PFKFB3 is essential for cell division and that it is regulated by APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP.
      Title: Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle.
    6. The siRNA-induced suppression of Skp2 increased p27 expression, decreased cellular proliferation, and increased apoptosis in human laryngeal carcinoma cells
      Title: Suppression of S-phase kinase-associated protein 2 induces apoptosis and inhibits tumor growth in human laryngeal cancer.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. These findings support a novel role for Hsp90-Sgt1 chaperones in ensuring the fidelity of Mis12 multiprotein complex assembly.
      Title: Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.
    9. Skp1 and Fbg3 were co-expressed in E. coli. The plate-shaped crystals belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 34.1, b = 76.6, c = 193.9 A and one molecule per asymmetric unit.
      Title: Crystallization and preliminary X-ray characterization of the Skp1-Fbg3 complex.
    10. The authors report that M-T5 can bind Akt and the host SCF complex (via Skp1) simultaneously in myxoma virus-infected cells.
      Title: The myxoma virus m-t5 ankyrin repeat host range protein is a novel adaptor that coordinately links the cellular signaling pathways mediated by Akt and Skp1 in virus-infected cells.
    Submit: New GeneRIF Correction See all (18)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_008861.2 AAF04464.1 BTRC    BIND  PubMed Skp1 interacts with Fbw1a. 
    NP_008861.2 AAF04466.1 FBXL3    BIND  PubMed Skp1 interacts with Fbl3a 
    NP_008861.2 AAF04468.1 FBXO4    BIND  PubMed Skp1 interacts with Fbx4. 
    NP_008861.2 AAF04469.1 FBXO5    BIND  PubMed Skp1 interacts with Fbx5. 
    NP_008861.2 AAF04470.1 FBXO6    BIND  PubMed Skp1 interacts with Fbx6a. 
    NP_008861.2 AAF04471.1 FBXO7    BIND  PubMed Skp1 interacts with Fbx7. 
    NP_008861.2 AAF04465.1 FBXW2    BIND  PubMed Skp1 interacts with Fbw2. 
    NP_733779.1 NP_003583.2 CUL1    BIND  PubMed SKP1A interacts with Cul1 [15-410] to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    NP_733779.1 AAM73631.1 FBXO18    BIND  PubMed FBH1 interacts with SKP1. 
    NP_733779.1 BAB87202.1 SKP2    BIND  PubMed Skp2-Fbox interacts with SKP1A to form part of the Cul1-Rbx1-Skp1-F Boxskp2 Scf Ubiquitin Ligase complex. 
    P63208 Q9Y297 BTRC    HPRD  PubMed  
    P63208 Q9HB71 CACYBP    HPRD  PubMed  
    P63208 P20248 CCNA2    HPRD  PubMed  
    P63208 Cell division cycle associated 3 CDCA3    HPRD  PubMed  
    P63208 Q02224 CENPE    HPRD  PubMed  
    P63208 Q13616 CUL1    HPRD  PubMed  
    P63208 Q14999 CUL7    HPRD  PubMed  
    P63208 Q9UMR2 DDX19B    HPRD  PubMed  
    P63208 Q9UKC9 FBXL2    HPRD  PubMed  
    P63208 Q9UKT7 FBXL3    HPRD  PubMed  
    P63208 Q9UKA2 FBXL4    HPRD  PubMed  
    P63208 Q9UKA1 FBXL5    HPRD  PubMed  
    P63208 Q96CD0 FBXL8    HPRD  PubMed  
    P63208 Q8NCQ5 FBXO15    HPRD  PubMed  
    P63208 Q8IX29 FBXO16    HPRD  PubMed  
    P63208 Q96EF6 FBXO17    HPRD  PubMed  
    P63208 Q8NFZ0 FBXO18    HPRD  PubMed  
    P63208 Q9UK22 FBXO2    HPRD  PubMed  
    P63208 Q8TCJ0 FBXO25    HPRD  PubMed  
    P63208 Q9UK99 FBXO3    HPRD  PubMed  
    P63208 Q969P5 FBXO32    HPRD  PubMed  
    P63208 Q9NWN3 FBXO34    HPRD  PubMed  
    P63208 Q9UKT5 FBXO4    HPRD  PubMed  
    P63208 Q9H4M3 FBXO44    HPRD  PubMed  
    P63208 Q9UKT4 FBXO5    HPRD  PubMed  
    P63208 Q9NRD1 FBXO6    HPRD  PubMed  
    P63208 Q9Y3I1 FBXO7    HPRD  PubMed  
    P63208 Q9NRD0 FBXO8    HPRD  PubMed  
    P63208 Q9UK97 FBXO9    HPRD  PubMed  
    P63208 Q9UKT8 FBXW2    HPRD  PubMed  
    P63208 Q969U6 FBXW5    HPRD  PubMed  
    P63208 Q969H0 FBXW7    HPRD  PubMed  
    P63208 Q8N3Y1 FBXW8    HPRD  PubMed  
    P63208 Q13098 GPS1    HPRD  PubMed  
    P63208 P25963 NFKBIA    HPRD  PubMed  
    P63208 Q15653 NFKBIB    HPRD  PubMed  
    P63208 O00221 NFKBIE    HPRD  PubMed  
    P63208 P62136 PPP1CA    HPRD  PubMed  
    P63208 P62877 RBX1    HPRD  PubMed  
    P63208 P63208 SKP1    HPRD  PubMed  
    P63208 Q13309 SKP2    HPRD  PubMed  
    P63208 Q9Y2Z0 SUGT1    HPRD  PubMed  
    P63208 O60907 TBL1X    HPRD  PubMed  
    BioGRID:112391 BioGRID:120228 BCOR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:122954 BORA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:118001 CACYBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:123657 CDCA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112391 BioGRID:107459 CDK9    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112391 BioGRID:107582 CKS1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:107880 CTNNB1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Protein-peptide 
    BioGRID:112391 BioGRID:114032 CUL1    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Co-fractionation; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:115159 CUL7    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:206665 Cdc23    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:198624 Cdk1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:207994 Dynll1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:108421 ETV6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:116298 FAF1    BioGRID  PubMed Affinity Capture-MS 
    AAF03128.1 FBXL2    BIND  PubMed Skp1 interacts with Fbl2. 
    BioGRID:112391 BioGRID:117615 FBXL3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    AAF03699.1 FBXL4    BIND  PubMed Skp1 interacts with Fbl4. 
    BioGRID:112391 BioGRID:117626 FBXL4    BioGRID  PubMed Reconstituted Complex 
    AAF03700.1 FBXL5    BIND  PubMed Skp1 interacts with Fbl5. 
    BioGRID:112391 BioGRID:117625 FBXL5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    NP_036436.1 FBXL7    BIND  PubMed An unspecified isoform of SKP1 interacts with FBL7. 
    BioGRID:112391 BioGRID:123173 FBXO11    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:124333 FBXO18    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:117623 FBXO2    BioGRID  PubMed Co-crystal Structure 
    AAF03702.1 FBXO3    BIND  PubMed Skp1 interacts with Fbx3. 
    BioGRID:112391 BioGRID:122890 FBXO31    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:125395 FBXO32    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112391 BioGRID:120359 FBXO34    BioGRID  PubMed Two-hybrid 
    BioGRID:112391 BioGRID:117656 FBXO4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    Q8TF61 FBXO41    BIND  PubMed An unspecified isoform of SKP1 interacts with KIAA1940. 
    BioGRID:112391 BioGRID:119962 FBXO42    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:125038 FBXO44    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:117655 FBXO5    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    NP_036311.2 FBXO7    BIND  PubMed Skp1 interacts with Fbx7. 
    BioGRID:112391 BioGRID:117326 FBXO7    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:117653 FBXO8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:116887 FBXW11    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    NP_036296.1 FBXW2    BIND  PubMed Skp1 interacts with Fbw2. 
    NP_036296.1 FBXW2    BIND  PubMed An unspecified isoform of SKP1 interacts with FBW2. 
    BioGRID:112391 BioGRID:117603 FBXW2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    Q9UKB7 FBXW4P1    BIND  PubMed An unspecified isoform of SKP1 interacts with FBW3. 
    BioGRID:112391 BioGRID:120581 FBXW7    BioGRID  PubMed Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex 
    NP_699179.2 FBXW8    BIND  PubMed An unspecified isoform of SKP1 interacts with an unspecified isoform of FBW6. 
    BioGRID:112391 BioGRID:117645 FBXW8    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112391 BioGRID:234572 Fbxo45    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:114093 GCM1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:109552 HSP90AA1    BioGRID  PubMed Reconstituted Complex 
    NP_036440.1 KDM2A    BIND  PubMed An unspecified isoform of SKP1 interacts with FBL11. 
    BioGRID:112391 BioGRID:124197 KDM2B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112391 BioGRID:114807 MED21    BioGRID  PubMed PCA; Reconstituted Complex 
    BioGRID:112391 BioGRID:115319 MED6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:110859 NFKBIA    BioGRID  PubMed Affinity Capture-Western; Protein-peptide; Reconstituted Complex 
    BioGRID:112391 BioGRID:124243 PCGF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:111136 PCK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:116356 RASSF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:111869 RBL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:115301 RBX1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112391 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex; Two-hybrid 
    BioGRID:112391 BioGRID:112509 SNRNP70    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:116115 SUGT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112391 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:118878 TBK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:112770 TBL1X    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112391 BioGRID:112872 TERF1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
    BioGRID:112391 BioGRID:112615 TRIM21    BioGRID  PubMed Affinity Capture-Western; Co-fractionation 
    BioGRID:112391 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:117507 UBXN7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112391 BioGRID:125434 UHRF2    BioGRID  PubMed Far Western 
    NP_057562.3 ZC3HC1    BIND  PubMed NIPA interacts with an unspecified isoform Skp1. 
    BioGRID:112391 BioGRID:119592 ZC3HC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem (from REACTOME)
      APC/C-mediated degradation of cell cycle proteins, organism-specific biosystemThe Anaphase Promoting Complex or Cyclosome (APC/C) functions during mitosis to promote sister chromatid separation and mitotic exit through the degradation of mitotic cyclins and securin. This compl...
    • Activation of NF-kappaB in B Cells, organism-specific biosystem (from REACTOME)
      Activation of NF-kappaB in B Cells, organism-specific biosystemDAG and calcium activate protein kinase C beta (PKC-beta, Kochs et al. 1991) which phosphorylates CARMA1 and other proteins (Sommer et al. 2005). Phosphorylated CARMA1 recruits BCL10 and MALT1 to for...
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Canonical Wnt signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Canonical Wnt signaling pathway, organism-specific biosystem
      Canonical Wnt signaling pathway
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Circadian Clock, organism-specific biosystem (from REACTOME)
      Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 heterodimer transactivates CRY and PER genes by binding E-box element...
    • Circadian rhythm - mammal, organism-specific biosystem (from KEGG)
      Circadian rhythm - mammal, organism-specific biosystem
      Circadian rhythm - mammal
    • Circadian rhythm - mammal, conserved biosystem (from KEGG)
      Circadian rhythm - mammal, conserved biosystem
      Circadian rhythm - mammal
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystem (from REACTOME)
      Cyclin A:Cdk2-associated events at S phase entry, organism-specific biosystemCyclin A:Cdk2 plays a key role in S phase entry by phosphorylation of proteins including Cdh1, Rb, p21 and p27. During G1 phase of the cell cycle, cyclin A is synthesized and associates with Cdk2. Af...
    • Cyclin D associated events in G1, organism-specific biosystem (from REACTOME)
      Cyclin D associated events in G1, organism-specific biosystemThree D-type cyclins are essential for progression from G1 to S-phase. These D cyclins bind to and activate both CDK4 and CDK6. The formation of all possible complexes between the D-type cyclins and...
    • Cyclin E associated events during G1/S transition, organism-specific biosystem (from REACTOME)
      Cyclin E associated events during G1/S transition, organism-specific biosystemThe transition from the G1 to S phase is controlled by the Cyclin E:Cdk2 complexes. As the Cyclin E:Cdk2 complexes are formed, the Cdk2 is phosphorylated by the Wee1 and Myt1 kinases. This phosphoryl...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Degradation of beta-catenin by the destruction complex, organism-specific biosystem (from REACTOME)
      Degradation of beta-catenin by the destruction complex, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Downstream Signaling Events Of B Cell Receptor (BCR), organism-specific biosystemSecond messengers (calcium, diacylglycerol, inositol 1,4,5-trisphosphate, and phosphatidyinositol 3,4,5-trisphosphate) trigger signaling pathways: NF-kappaB is activated via protein kinase C beta, RA...
    • G1 Phase, organism-specific biosystem (from REACTOME)
      G1 Phase, organism-specific biosystemEarly cell cycle progression in G1 is under the control of the D-type cyclins together with Cdk4 and Cdk6. An important target for these CDKs is the Retinoblastoma (Rb) protein, which when phosphoryl...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • Herpes simplex infection, organism-specific biosystem (from KEGG)
      Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Herpes simplex infection, conserved biosystem (from KEGG)
      Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystem (from REACTOME)
      NOTCH1 Intracellular Domain Regulates Transcription, organism-specific biosystemNICD1 produced by activation of NOTCH1 in response to Delta and Jagged ligands (DLL/JAG) presented in trans, traffics to the nucleus where it acts as a transcription regulator. In the nucleus, NICD1 ...
    • Notch signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
      Notch signaling pathway, organism-specific biosystem
      Notch signaling pathway
    • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
    • Oocyte meiosis, organism-specific biosystem (from KEGG)
      Oocyte meiosis, organism-specific biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Oocyte meiosis, conserved biosystem (from KEGG)
      Oocyte meiosis, conserved biosystemDuring meiosis, a single round of DNA replication is followed by two rounds of chromosome segregation, called meiosis I and meiosis II. At meiosis I, homologous chromosomes recombine and then segrega...
    • Prolactin receptor signaling, organism-specific biosystem (from REACTOME)
      Prolactin receptor signaling, organism-specific biosystemProlactin (PRL) is a hormone secreted mainly by the anterior pituitary gland. It was originally identified by its ability to stimulate the development of the mammary gland and lactation, but is now k...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystem (from REACTOME)
      Regulation of APC/C activators between G1/S and early anaphase, organism-specific biosystemThe APC/C is activated by either Cdc20 or Cdh1. While both activators associate with the APC/C, they do so at different points in the cell cycle and their binding is regulated differently (see Zacha...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Regulation of mitotic cell cycle, organism-specific biosystem (from REACTOME)
      Regulation of mitotic cell cycle, organism-specific biosystem
      Regulation of mitotic cell cycle
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystem (from REACTOME)
      SCF(Skp2)-mediated degradation of p27/p21, organism-specific biosystemDuring G1, the activity of cyclin-dependent kinases (CDKs) is kept in check by the CDK inhibitors (CKIs) p27 and p21, thereby preventing premature entry into S phase (see Guardavaccaro and Pagano, 20...
    • SCF-BTRC complex, organism-specific biosystem (from KEGG)
      SCF-BTRC complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, organism-specific biosystem (from KEGG)
      SCF-FBS complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBS complex, conserved biosystem (from KEGG)
      SCF-FBS complex, conserved biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-FBW7 complex, organism-specific biosystem (from KEGG)
      SCF-FBW7 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-SKP2 complex, organism-specific biosystem (from KEGG)
      SCF-SKP2 complex, organism-specific biosystemStructural complex; Genetic information processing; Ubiquitin system
    • SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystem (from REACTOME)
      SCF-beta-TrCP mediated degradation of Emi1, organism-specific biosystemEmi1 destruction in early mitosis requires the SCF�²TrCP ubiquitin ligase complex. Binding of �²TrCP to Emi1 occurs in late prophase and requires phosphorylation at the DSGxxS consensus motif as...
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
      Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Signaling by NOTCH, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH, organism-specific biosystemThe Notch Signaling Pathway (NSP) is a highly conserved pathway for cell-cell communication. NSP is involved in the regulation of cellular differentiation, proliferation, and specification. For exam...
    • Signaling by NOTCH1, organism-specific biosystem (from REACTOME)
      Signaling by NOTCH1, organism-specific biosystemNOTCH1 functions as both a transmembrane receptor presented on the cell surface and as a transcriptional regulator in the nucleus.NOTCH1 receptor presented on the plasma membrane is activated by a me...
    • Signaling by Wnt, organism-specific biosystem (from REACTOME)
      Signaling by Wnt, organism-specific biosystemThe beta-catenin destruction complex plays a key role in the canonical Wnt signaling pathway. In the absence of Wnt signaling, this complex controls the levels of cytoplamic beta-catenin. Beta-cateni...
    • Signaling by the B Cell Receptor (BCR), organism-specific biosystem (from REACTOME)
      Signaling by the B Cell Receptor (BCR), organism-specific biosystemMature B cells express IgM and IgD immunoglobulins which are complexed at the plasma membrane with Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) to form the B cell receptor (BCR) (Fu et al. 1974, F...
    • TGF-beta Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TGF-beta Receptor Signaling Pathway, organism-specific biosystem"The TGF beta receptors TGFBR1 and TGFBR2 belong to a subfamily of membrane-bound serine/threonine kinases which are designated as Type I or II based on their structural and functional properties. Th...
    • TGF-beta signaling pathway, organism-specific biosystem (from KEGG)
      TGF-beta signaling pathway, organism-specific biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TGF-beta signaling pathway, conserved biosystem (from KEGG)
      TGF-beta signaling pathway, conserved biosystemThe transforming growth factor-beta (TGF-beta) family members, which include TGF-betas, activins and bone morphogenetic proteins (BMPs), are structurally related secreted cytokines found in species r...
    • TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
      TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem"The Tumor Necrosis Factor alpha is a proinflammatory cytokine belonging to the TNF superfamily. It signals through 2 separate receptors - TNFRSF1A and TNFRSF1B, both members of the TNF receptor supe...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Vpu mediated degradation of CD4, organism-specific biosystem (from REACTOME)
      Vpu mediated degradation of CD4, organism-specific biosystemThe HIV-1 Vpu protein promotes the degradation of the CD4 receptor by recruiting an SCF like ubiquitination complex that promotes CD4 degradation. Vpu links beta-TrCP to CD4 at the ER membrane thro...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • Wnt signaling pathway, organism-specific biosystem (from KEGG)
      Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
    • Wnt signaling pathway, conserved biosystem (from KEGG)
      Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    ubiquitin-protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		  
    Process Evidence Code Pubs
    G1 phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    		  
    histone H2A monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with PcG protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    S-phase kinase-associated protein 1
    Names
    S-phase kinase-associated protein 1
    SIII
    OCP-2
    p19skp1
    organ of Corti protein 2
    organ of Corti protein II
    cyclin A/CDK2-associated p19
    transcription elongation factor B
    cyclin A/CDK2-associated protein p19
    cyclin-A/CDK2-associated protein p19
    RNA polymerase II elongation factor-like protein OCP2
    NP_008861.2
    NP_733779.1
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006930.3 → NP_008861.2  S-phase kinase-associated protein 1 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript variant but encodes the shorter isoform (a).
      Source sequence(s)
      AI025746, AI028694, BC025673, BC065730, BI670085, BQ632052
      Consensus CDS
      CCDS4172.1
      UniProtKB/Swiss-Prot
      P63208
      Related
      ENSP00000429472, OTTHUMP00000159380, ENST00000522552, OTTHUMT00000251163
      Conserved Domains (3) summary
      COG5201
      Location:1 – 153
      Blast Score: 350
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:85 – 153
      Blast Score: 340
      Skp1; Skp1 family, dimerisation domain
      cl02518
      Location:1 – 112
      Blast Score: 303
      BTB; BTB/POZ domain

    2. NM_170679.2 → NP_733779.1  S-phase kinase-associated protein 1 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) utilizes an alternate splice site in the 3' coding region, compared to variant 1. This results in a frameshift and slightly longer protein (isoform b), compared to isoform a.
      Source sequence(s)
      AI025746, AI028694, BC065730, BI670085, BQ632052, Z47087
      Consensus CDS
      CCDS4171.1
      UniProtKB/Swiss-Prot
      P63208
      Related
      ENSP00000231487, OTTHUMP00000159379, ENST00000353411, OTTHUMT00000251162
      Conserved Domains (3) summary
      COG5201
      Location:1 – 163
      Blast Score: 371
      SKP1; SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones]
      pfam01466
      Location:85 – 162
      Blast Score: 376
      Skp1; Skp1 family, dimerisation domain
      cl02518
      Location:1 – 112
      Blast Score: 298
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000005.9 Reference GRCh37.p5 Primary Assembly

      Range
      133492082..133512724, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000137.1 Alternate HuRef

      Range
      128677052..128697683, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC011336.5 (27213..31597) None
    genomic AC104109.3 (146176..161906) None
    genomic CH471062.2 EAW62270.1
      EAW62271.1
      EAW62272.1
      EAW62273.1
      EAW62274.1
      EAW62275.1
      EAW62276.1
    genomic L49170.1 AAB50264.1
    genomic L49173.1 AAB50265.1
    genomic L49176.1 AAB50032.1
    mRNA AI025746.1 None
    mRNA AI028694.1 None
    mRNA AK057110.1 None
    mRNA BC009839.2 AAH09839.1
    mRNA BC020798.1 AAH20798.1
    mRNA BC025673.1 AAH25673.1
    mRNA BC065730.1 AAH65730.1
    mRNA BI552966.1 None
    mRNA BI670085.1 None
    mRNA BQ632052.1 None
    mRNA U33760.1 AAC50241.1
    mRNA U37558.1 AAA79202.1
    mRNA Z47087.1 CAA87392.1
    other-genetic DQ891512.2 ABM82438.1
    other-genetic DQ894703.2 ABM85629.1
    other-genetic EU831628.1 ACE87228.1
    other-genetic EU831713.1 ACE86547.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P63208.2 GenPept UniProtKB/Swiss-Prot:P63208
    P78389 GenPept UniProtKB/TrEMBL:P78389
    P78561 GenPept UniProtKB/TrEMBL:P78561
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...