BMP2 bone morphogenetic protein 2 [Homo sapiens] - Gene

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Summary

Official Symbol: BMP2provided by HGNC
Official Full Name: bone morphogenetic protein 2provided by HGNC
Primary source: HGNC:1069
See related: Ensembl:ENSG00000125845; HPRD:00206; MIM:112261; Vega:OTTHUMG00000031833
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BDA2; BMP2A
Summary: The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 20p12

Sequence :: Chromosome: 20; NC_000020.10 (6748745..6760910)

See BMP2 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our data suggest that miR-140 has a large number of targets conserved between human and chicken and we validate one of these, BMP2.
Title: mRNA expression profiling reveals conserved and non-conserved miR-140 targets.
The expressions of VEGF, bFGF, and BMP-2 mRNAs decline in traumatic and nontraumatic avascular necrosis of femoral head.
Title: [Relationship between the bone mass and the expressions of vascular endothelial growth factor, basic fibroblast growth factor, and bone morphogenetic protein 2 mRNA in avascular necrosis of femoral head].
The expression level of BMP2 is strongly elevated in kidney cancer
Title: mRNA expression of bone morphogenetic proteins and their receptors in human renal cell carcinoma.
after gamma-irradiation and transplantation, mesenchymal stem cells and rhBMP2 additively promoted and improved hematopoietic restoration and function
Title: The additive effect of mesenchymal stem cells and bone morphogenetic protein 2 on γ-irradiated bone marrow in mice.
BMP2 induces osteoblast differentiation through Runx2-dependent ATF6 expression, which directly regulates Oc transcription.
Title: BMP2 protein regulates osteocalcin expression via Runx2-mediated Atf6 gene transcription.
Tissue scaffold loaded with low-dose rhBMP-2 is comparable to autograft bone as a bone graft substitute in this large animal model of anterior lumbar body fusion.
Title: Fusion performance of low-dose recombinant human bone morphogenetic protein 2 and bone marrow-derived multipotent stromal cells in biodegradable scaffolds: a comparative study in a large animal model of anterior lumbar interbody fusion.
BMP-2 had a similar binding affinity for each extracellular matrix, while TGF-beta1 had a greater affinity for ECMs produced by osteoblasts from control compared to craniosynostosis patients
Title: Differential growth factor adsorption to calvarial osteoblast-secreted extracellular matrices instructs osteoblastic behavior.
To increase the osteogenic and angiogenic effects of marrow-derived mesenchymal stromal cells (MSCs), we co-transfected (by means of lentivirus) the human angiopoietin-1 gene (hAng-1) and human bone morphogenetic protein 2 gene (hBMP2) into MSCs.
Title: Osteogenic and angiogenic effects of mesenchymal stromal cells with co-transfected human Ang-1 gene and BMP2 gene.
ET-1 and BMP2 have opposing effects on chloride channel activity in human fibroblasts.
Title: Opposing effects of bone morphogenetic protein-2 and endothelin-1 on lung fibroblast chloride currents.
Report few complications directly attributed to rhBMP-2/ACS in posterolateral spinal fusion.
Title: Complications with recombinant human bone morphogenic protein-2 in posterolateral spine fusion: a consecutive series of 1037 cases.

Submit: New GeneRIF Correction See all (250)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

HFE hemochromatosis, modifier of

MIM: 235200

Many sequence variants affecting diversity of adult human height.

Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	BMP-2 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Source	Pubs	Description
P12643	Q04771	ACVR1	HPRD	PubMed
P12643	Q13705	ACVR2B	HPRD	PubMed
P12643	P50553	ASCL1	HPRD	PubMed
P12643	P12643	BMP2	HPRD	PubMed
P12643	Q8N8U9	BMPER	HPRD	PubMed
P12643	P36894	BMPR1A	HPRD	PubMed
P12643	O00238	BMPR1B	HPRD	PubMed
P12643	Q13873	BMPR2	HPRD	PubMed
P12643	Q9H2X0	CHRD	HPRD	PubMed
P12643	Q6WN34	CHRDL2	HPRD	PubMed
P12643	P02458	COL2A1	HPRD	PubMed
P12643	P17813	ENG	HPRD	PubMed
P12643	O60565	GREM1	HPRD	PubMed
P12643	Q9H772	GREM2	HPRD	PubMed
P12643	P08493	MGP	HPRD	PubMed
P12643	Q13253	NOG	HPRD	PubMed
P12643	Q6X4U4	SOSTDC1	HPRD	PubMed
P12643	P01137	TGFB1	HPRD	PubMed
P12643	P61812	TGFB2	HPRD	PubMed
BioGRID:107118	BioGRID:115404	ACTR2	BioGRID	PubMed	Reconstituted Complex
BioGRID:107118	BioGRID:107125	BMPR1A	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:107118	BioGRID:107126	BMPR1B	BioGRID	PubMed	Reconstituted Complex
BioGRID:107118	BioGRID:107127	BMPR2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107118	BioGRID:107677	COL2A1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107118	BioGRID:108337	ENG	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107118	BioGRID:110412	MGP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107118	BioGRID:117428	SOSTDC1	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
BMP receptor binding	IDA Inferred from Direct Assay more info	PubMed
SMAD binding	IDA Inferred from Direct Assay more info	PubMed
activin receptor activity, type II	TAS Traceable Author Statement more info
cytokine activity	IEA Inferred from Electronic Annotation more info
growth factor activity	IEA Inferred from Electronic Annotation more info
phosphatase activator activity	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IEA Inferred from Electronic Annotation more info
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IEA Inferred from Electronic Annotation more info
receptor binding	TAS Traceable Author Statement more info	PubMed
retinol dehydrogenase activity	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein serine/threonine kinase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
BMP signaling pathway	TAS Traceable Author Statement more info
BMP signaling pathway involved in heart induction	IDA Inferred from Direct Assay more info	PubMed
Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
atrioventricular valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
bone mineralization involved in bone maturation	IDA Inferred from Direct Assay more info	PubMed
branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cardiac cell differentiation	IDA Inferred from Direct Assay more info	PubMed
cardiac cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
cardiac epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
cardiac muscle tissue morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell fate commitment	ISS Inferred from Sequence or Structural Similarity more info
cell-cell signaling	TAS Traceable Author Statement more info	PubMed
cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info
cellular response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
corticotropin hormone secreting cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
embryo development	ISS Inferred from Sequence or Structural Similarity more info
embryonic heart tube anterior/posterior pattern specification	ISS Inferred from Sequence or Structural Similarity more info
endocardial cushion morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
epithelial to mesenchymal transition	IDA Inferred from Direct Assay more info	PubMed
growth	IEA Inferred from Electronic Annotation more info
heart development	ISS Inferred from Sequence or Structural Similarity more info
in utero embryonic development	ISS Inferred from Sequence or Structural Similarity more info
inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
inner ear development	ISS Inferred from Sequence or Structural Similarity more info
mesenchymal cell differentiation	IDA Inferred from Direct Assay more info	PubMed
mesenchymal cell proliferation involved in ureteric bud development	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
odontogenesis of dentin-containing tooth	ISS Inferred from Sequence or Structural Similarity more info
organ morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
ovulation cycle	IEA Inferred from Electronic Annotation more info
oxidation-reduction process	IEA Inferred from Electronic Annotation more info
pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
pericardium development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Wnt receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of Wnt receptor signaling pathway by BMP signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
positive regulation of astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of bone mineralization	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cartilage development	IDA Inferred from Direct Assay more info	PubMed
positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial to mesenchymal transition	IEA Inferred from Electronic Annotation more info
positive regulation of fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neurogenesis	IEA Inferred from Electronic Annotation more info
positive regulation of neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of odontogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ossification	IDA Inferred from Direct Assay more info	PubMed
positive regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of osteoblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of pathway-restricted SMAD protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of pathway-restricted SMAD protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
protein destabilization	IEA Inferred from Electronic Annotation more info
regulation of odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
response to retinoic acid	IEA Inferred from Electronic Annotation more info
skeletal system development	TAS Traceable Author Statement more info	PubMed
telencephalon development	IDA Inferred from Direct Assay more info	PubMed
telencephalon regionalization	ISS Inferred from Sequence or Structural Similarity more info
thyroid-stimulating hormone-secreting cell differentiation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info
extracellular space	IEA Inferred from Electronic Annotation more info
membrane-bounded vesicle	IEA Inferred from Electronic Annotation more info
protein complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: bone morphogenetic protein 2

Names: bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_023233.1 RefSeqGene

Range

5001..17166

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001200.2 → NP_001191.1 bone morphogenetic protein 2 preproprotein

Status: REVIEWED

Source sequence(s)

AL035668, BC069214, M22489

Consensus CDS

CCDS13099.1

UniProtKB/TrEMBL

C8C060

UniProtKB/Swiss-Prot

P12643

Related

ENSP00000368104, OTTHUMP00000030228, ENST00000378827, OTTHUMT00000077918

Conserved Domains (2) summary

pfam00688
Location:42 – 267
Blast Score: 548

TGFb_propeptide; TGF-beta propeptide

cl02510
Location:296 – 396
Blast Score: 484

TGF_beta; Transforming growth factor beta like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

6748745..6760910

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

6705637..6717811

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF040249.1	AAF21646.1
genomic	AL035668.15	CAB82007.1
genomic	CH471133.3	EAX10386.1
		EAX10387.1
genomic	GQ335529.1	ACV32585.1
genomic	GQ335531.1	ACV32587.1
genomic	HI961649.1	CBY84970.1
mRNA	BC069214.1	None
mRNA	M22489.1	AAA51834.1
other-genetic	BC140325.1	AAI40326.1
other-genetic	BC148689.1	AAI48690.1
other-genetic	EU832168.1	ACE87518.1
other-genetic	EU832262.1	ACE86832.1