SKI v-ski sarcoma viral oncogene homolog (avian) [Homo sapiens] - Gene

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Summary

Official Symbol: SKIprovided by HGNC
Official Full Name: v-ski sarcoma viral oncogene homolog (avian)provided by HGNC
Primary source: HGNC:10896
See related: Ensembl:ENSG00000157933; HPRD:01271; MIM:164780; Vega:OTTHUMG00000001407
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SKV
Summary: This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]

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Genomic context

Location :: 1p36.33

Sequence :: Chromosome: 1; NC_000001.10 (2160134..2241652)

See SKI in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ski expression in breast neoplasms is associated with longer overall and disease-free survival.
Title: Differential effect of the expression of TGF-β pathway inhibitors, Smad-7 and Ski, on invasive breast carcinomas: relation to biologic behavior.
Forced expression of miR-29a down-regulated SKI and its target gene, Nr-CAM, whereas miR-29a inhibition induced SKI expression.
Title: MicroRNA29a regulates the expression of the nuclear oncogene Ski.
These results suggest that c-Ski is likely involved in the carcinogenesis of CCA induced by O. viverrini infection
Title: Involvement of c-Ski oncoprotein in carcinogenesis of cholangiocacinoma induced by Opisthorchis viverrini and N-nitrosodimethylamine.
impairment of SKI expression is not the leading mechanism involved in the growth-suppressive effect of miR-155 found in this malignancy.
Title: MicroRNA-155 targets the SKI gene in human melanoma cell lines.
These data identify Ski as a novel target of Aurora A and contribute to an understanding of the role of these proteins in the mitotic process.
Title: Identification of Ski as a target for Aurora A kinase.
Ski correlated with poor survival in the patients with TGF-beta-positive advanced gastric cancer.
Title: Expression of thrombospondin-1 and Ski are prognostic factors in advanced gastric cancer.
Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.
Title: Suppression of p53 activity through the cooperative action of Ski and histone deacetylase SIRT1.
Results identified serine 515 as a phosphorylation site of c-Ski which affects its electrophoretic motility.
Title: Identification of a phosphorylation site in c-Ski as serine 515.
c-Ski overexpression is associated with tumor progression.
Title: The oncoprotein c-ski functions as a direct antagonist of the transforming growth factor-{beta} type I receptor.
the results suggest that association with Ski leads to inhibition of Siah2 E3 ubiquitin ligase activity and in this way, the Ski protein inhibits Siah2-mediated proteasomal degradation of HDAC3.
Title: The Ski protein negatively regulates Siah2-mediated HDAC3 degradation.

Submit: New GeneRIF Correction See all (45)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_003027.1	NP_003027.1	SKI	BIND	PubMed	c-Ski homodimerizes with itself.
NP_003027.1	NP_005892.1	SMAD2	BIND	PubMed	c-Ski interacts with Smad2. This interaction was modeled on a demonstrated interaction between Smad2 from an unspecified source and human c-Ski.
NP_003027.1	NP_005893.1	SMAD3	BIND	PubMed	c-Ski interacts with Smad3. This interaction was modeled on a demonstrated interaction between Smad3 from an unspecified source and human c-Ski.
NP_003027.1	NP_005350.1	SMAD4	BIND	PubMed	c-Ski interacts with Smad4. This interaction was modelled on a demonstrated interaction between Smad4 from an unspecified source and human c-Ski.
NP_003027.1	NP_005350.1	SMAD4	BIND	PubMed	Smad4 interacts with Ski. This interaction was modeled on a demonstrated interaction between human Smad4 and Ski from an unspecified species.
NP_003027.1	NP_006073.2	TUBA1B	BIND	PubMed	Ski interacts with alpha-tubulin.
P12755	P10070	GLI2	HPRD	PubMed
P12755	P10071	GLI3	HPRD	PubMed
P12755	Q9H2X6	HIPK2	HPRD	PubMed
P12755	P05412	JUN	HPRD	PubMed
P12755	P51608	MECP2	HPRD	PubMed
P12755	O75376	NCOR1	HPRD	PubMed
P12755	Q14938	NFIX	HPRD	PubMed
P12755	P29590	PML	HPRD	PubMed
P12755	Q96ST3	SIN3A	HPRD	PubMed
P12755	P12755	SKI	HPRD	PubMed
P12755	P12757	SKIL	HPRD	PubMed
P12755	Q15796	SMAD2	HPRD	PubMed
P12755	P84022	SMAD3	HPRD	PubMed
P12755	Q13485	SMAD4	HPRD	PubMed
P12755	Q13573	SNW1	HPRD	PubMed
BioGRID:112388	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:108441	EYA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:108893	GATA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:108998	GLI2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:112388	BioGRID:108999	GLI3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112388	BioGRID:114368	HDAC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:118815	HIPK2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:109928	JUN	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:110368	MECP2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:110687	MYB	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:114973	NCOR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:110856	NFIX	BioGRID	PubMed	Phenotypic Enhancement; Reconstituted Complex
BioGRID:112388	BioGRID:111384	PML	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:122023	PRDM16	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:115688	PRMT5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:111849	RARA	BioGRID	PubMed	Affinity Capture-Western; Co-localization
BioGRID:112388	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:112373	SIAH2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:116983	SIRT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:112386	SIX1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:112388	SKI	BioGRID	PubMed	Reconstituted Complex
BioGRID:112388	BioGRID:112389	SKIL	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:110261	SMAD1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:110262	SMAD2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112388	BioGRID:110263	SMAD3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:110264	SMAD4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Reconstituted Complex
BioGRID:112388	BioGRID:110265	SMAD5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:116597	SNW1	BioGRID	PubMed	Affinity Capture-Western; Phenotypic Suppression; Reconstituted Complex; Two-hybrid
BioGRID:112388	BioGRID:112566	SPI1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:122834	TBL1XR1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:112904	TGFBR1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:112388	BioGRID:113010	TP53	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112388	BioGRID:115457	TRIM28	BioGRID	PubMed	Reconstituted Complex
BioGRID:112388	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western

Function	Evidence Code	Pubs
SMAD binding	IPI Inferred from Physical Interaction more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
histone deacetylase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
repressing transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed
transcription corepressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
BMP signaling pathway	TAS Traceable Author Statement more info
SMAD protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
anterior/posterior axis specification	ISS Inferred from Sequence or Structural Similarity more info
bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info
camera-type eye morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
cell motility	NAS Non-traceable Author Statement more info	PubMed
cell proliferation	NAS Non-traceable Author Statement more info	PubMed
embryonic limb morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
face morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
lens morphogenesis in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
myelination in peripheral nervous system	ISS Inferred from Sequence or Structural Similarity more info
myotube differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of BMP signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of Schwann cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of activin receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of catalytic activity	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of fibroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of histone deacetylation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of osteoblast differentiation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
neural tube closure	ISS Inferred from Sequence or Structural Similarity more info
nose morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
olfactory bulb development	ISS Inferred from Sequence or Structural Similarity more info
palate development	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Wnt receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	ISS Inferred from Sequence or Structural Similarity more info
protein homotrimerization	IDA Inferred from Direct Assay more info	PubMed
regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
retina development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
skeletal muscle fiber development	ISS Inferred from Sequence or Structural Similarity more info
somatic stem cell maintenance	ISS Inferred from Sequence or Structural Similarity more info
transcription, DNA-dependent	ISS Inferred from Sequence or Structural Similarity more info
transforming growth factor beta receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
PML body	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
nuclear body	IDA Inferred from Direct Assay more info	PubMed
nuclear part	ISS Inferred from Sequence or Structural Similarity more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
transcription factor complex	ISS Inferred from Sequence or Structural Similarity more info
transcriptional repressor complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Preferred Names: ski oncogene

Names: ski oncogene; ski oncoprotein; proto-oncogene c-Ski

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013084.1 RefSeqGene

Range

5001..86519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_003036.3 → NP_003027.1 ski oncogene

Status: REVIEWED

Source sequence(s)

AL590822, X15218

Consensus CDS

CCDS39.1

UniProtKB/Swiss-Prot

P12755

Related

ENSP00000367797, OTTHUMP00000001507, ENST00000378536, OTTHUMT00000004070

Conserved Domains (4) summary

pfam02437
Location:96 – 192
Blast Score: 426

Ski_Sno; SKI/SNO/DAC family

TIGR02168
Location:541 – 678
Blast Score: 95

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cl07406
Location:219 – 312
Blast Score: 486

c-SKI_SMAD_bind; c-SKI Smad4 binding domain

cl12013
Location:543 – 605
Blast Score: 89

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

2160134..2241652

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

1435430..1516081

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL590822.37 (85748..167266)	None
genomic	AY331180.1	AAP94890.1
genomic	AY334557.1	AAP97864.1
genomic	AY338687.1	AAQ16119.1
genomic	CH471183.1	EAW56117.1
		EAW56118.1
mRNA	AK309515.1	None
mRNA	X15218.1	CAA33288.1
other-genetic	BC156044.1	AAI56045.1
other-genetic	BC157082.1	AAI57083.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P12755.1	GenPept	UniProtKB/Swiss-Prot:P12755
Q7Z459	GenPept	UniProtKB/TrEMBL:Q7Z459
Q7Z461	GenPept	UniProtKB/TrEMBL:Q7Z461
Q7Z462	GenPept	UniProtKB/TrEMBL:Q7Z462