RASAL3 RAS protein activator like 3 [Homo sapiens] - Gene

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Summary

Official Symbol: RASAL3provided by HGNC
Official Full Name: RAS protein activator like 3provided by HGNC
Primary source: HGNC:26129
See related: Ensembl:ENSG00000105122
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FLJ00087; FLJ21438; DKFZp667E013

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Genomic context

Location :: 19p13.12

Sequence :: Chromosome: 19; NC_000019.9 (15562438..15575382, complement)

See RASAL3 in Epigenomics, MapViewer

Chromosome 19 - NC_000019.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
BioGRID:122348	BioGRID:113363	YWHAE		BioGRID	PubMed	Two-hybrid
BioGRID:122348	BioGRID:113366	YWHAZ		BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
Ras GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
negative regulation of Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
positive regulation of Ras GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
intracellular	IEA Inferred from Electronic Annotation more info
intrinsic to internal side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Preferred Names: RAS protein activator like-3

Names: RAS protein activator like-3

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022904.1 → NP_075055.1 RAS protein activator like-3

Status: VALIDATED

Source sequence(s)

AK024488, AK122587, DA994945

Consensus CDS

CCDS46006.1

UniProtKB/Swiss-Prot

Q86YV0

UniProtKB/TrEMBL

Q9H7J2

Related

ENSP00000341905, ENST00000343625

Conserved Domains (5) summary

cd05136
Location:430 – 738
Blast Score: 1214

RasGAP_DAB2IP; The DAB2IP family of Ras GTPase-activating proteins includes DAB2IP, nGAP, and Syn GAP. Disabled 2 interactive protein, (DAB2IP; also known as ASK-interacting protein 1 (AIP1)), is a member of the GTPase-activating proteins, down-regulates Ras-mediated ...

TIGR00606
Location:862 – 986
Blast Score: 90

rad50; rad50

pfam12329
Location:889 – 949
Blast Score: 93

TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

cl00273
Location:230 – 291
Blast Score: 167

PH-like; Pleckstrin homology-like domain

cl14603
Location:294 – 357
Blast Score: 100

C2; C2 domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000019.9 Reference GRCh37.p5 Primary Assembly

Range

15562438..15575382, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000151.1 Alternate HuRef

Range

15130271..15143115, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC011492.8 (7607..23997)	None
mRNA	AK024488.1	BAB15778.1
mRNA	AK025091.1	BAB15064.1
mRNA	AK122587.1	BAC56928.1
mRNA	AL832868.1	None
mRNA	BC030281.1	AAH30281.1
mRNA	DA994945.1	None