These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029659.1 RefSeqGene
- Range
- 5001..52187
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001199.3 → NP_001190.1 bone morphogenetic protein 1 isoform 1 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (1, also known as BMP1-1) represents the shortest transcript and encodes the shorter isoform (1).
- Source sequence(s)
-
AC105206, BC136679, BE619065, DA720194, M22488
- Consensus CDS
-
CCDS34856.1
- UniProtKB/Swiss-Prot
-
P13497
- Related
- ENSP00000306121, OTTHUMP00000227399, ENST00000306349, OTTHUMT00000375386
- Conserved Domains (4) summary
-
- cd00041
Location:591 – 702
Blast Score: 336
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00054
Location:547 – 588
Blast Score: 112
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- cd04281
Location:126 – 320
Blast Score: 1021
- ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
- pfam01400
Location:128 – 321
Blast Score: 828
- Astacin; Astacin (Peptidase family M12A)
-
NM_006129.4 → NP_006120.1 bone morphogenetic protein 1 isoform 3 precursor
Status: REVIEWED
- Description
- Transcript Variant: This variant (3, also known as BMP1-3) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is longer than isoform 1.
- Source sequence(s)
-
AC105206, BC136679, BU627735, DA720194
- Consensus CDS
-
CCDS6026.1
- UniProtKB/Swiss-Prot
-
P13497
- Related
- ENSP00000305714, OTTHUMP00000123391, ENST00000306385, OTTHUMT00000214995
- Conserved Domains (5) summary
-
- cd00041
Location:747 – 855
Blast Score: 334
- CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
- cd00054
Location:547 – 588
Blast Score: 108
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
- cd04281
Location:126 – 320
Blast Score: 1021
- ZnMc_BMP1_TLD; Zinc-dependent metalloprotease; BMP1/TLD-like subfamily. BMP1 (Bone morphogenetic protein 1) and TLD (tolloid)-like metalloproteases play vital roles in extracellular matrix formation, by cleaving precursor proteins such as enzymes, structural proteins, ...
- pfam01400
Location:128 – 321
Blast Score: 825
- Astacin; Astacin (Peptidase family M12A)
- cl09941
Location:703 – 733
Blast Score: 100
- EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
RNA
-
NR_033403.1 RNA Sequence
- Description
- Transcript Variant: This variant (4) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC105206, BC144366, BU627735, DA720194
-
NR_033404.1 RNA Sequence
- Description
- Transcript Variant: This variant (5) uses an alternate splice site in an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
- Source sequence(s)
-
AC105206, BC009305, BE619065, DA720194, M22488
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000008.10 Reference GRCh37.p5 Primary Assembly
- Range
- 22022653..22069839
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000140.1 Alternate HuRef
- Range
- 20564967..20612031
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
The following Reference Sequences have been suppressed. Explain
These RefSeqs were suppressed for the cited
reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links,
or BLAST links (BLink), but may still be retrieved by clicking on their
accession.version below.
-
NM_006128.2: Suppressed sequence
- Description
- NM_006128.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
-
NM_006130.1: Suppressed sequence
- Description
- NM_006130.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.
-
NM_006131.1: Suppressed sequence
- Description
- NM_006131.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.
-
NM_006132.1: Suppressed sequence
- Description
- NM_006132.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay candidate.