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PAPOLG poly(A) polymerase gamma [ Homo sapiens (human) ]

Gene ID: 64895, updated on 26-May-2016
Official Symbol
PAPOLGprovided by HGNC
Official Full Name
poly(A) polymerase gammaprovided by HGNC
Primary source
HGNC:HGNC:14982
See related
Ensembl:ENSG00000115421 HPRD:11420; MIM:616865; Vega:OTTHUMG00000129419
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the poly(A) polymerase family which catalyzes template-independent extension of the 3' end of a DNA/RNA strand. This enzyme shares 60% identity to the well characterized poly(A) polymerase II (PAPII) at the amino acid level. These two enzymes have similar organization of structural and functional domains. This enzyme is exclusively localized in the nucleus and exhibits both nonspecific and CPSF (cleavage and polyadenylation specificity factor)/AAUAAA-dependent polyadenylation activity. This gene is located on chromosome 2 in contrast to the PAPII gene, which is located on chromosome 14. [provided by RefSeq, Jul 2008]
Orthologs
Location:
2p16.1
Exon count:
22
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (60756230..60802086)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (60983365..61029221)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 13 Neighboring gene ATPase Na+/K+ transporting subunit beta 3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1185 Neighboring gene ribosomal protein L21 pseudogene 33 Neighboring gene REL proto-oncogene, NF-kB subunit

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat The poly(A) site in the HIV-1 5'-LTR is occluded in a Tat-dependent manner, suggesting a role for Tat in regulating this nucleotide signal PubMed

Go to the HIV-1, Human Interaction Database

  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ11805, FLJ12972, FLJ13482, FLJ14187, MGC133307, MGC133308

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
RNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IDA
Inferred from Direct Assay
more info
PubMed 
polynucleotide adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
RNA polyadenylation IDA
Inferred from Direct Assay
more info
PubMed 
mRNA polyadenylation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
poly(A) polymerase gamma
Names
PAP-gamma
SRP RNA 3' adenylating enzyme/pap2
SRP RNA 3'-adenylating enzyme
neo-PAP
neo-poly(A) polymerase
nuclear poly(A) polymerase gamma
polynucleotide adenylyltransferase gamma
NP_075045.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022894.3NP_075045.2  poly(A) polymerase gamma

    See identical proteins and their annotated locations for NP_075045.2

    Status: REVIEWED

    Source sequence(s)
    AB209304, AC011245, AI419423, BC111701, DB082179
    Consensus CDS
    CCDS1863.1
    UniProtKB/Swiss-Prot
    Q9BWT3
    Related
    ENSP00000238714, OTTHUMP00000159787, ENST00000238714, OTTHUMT00000251577
    Conserved Domains (3) summary
    cd05402
    Location:59213
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam04926
    Location:365507
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:16364
    PAP_central; Poly(A) polymerase central domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    60756230..60802086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005264500.2XP_005264557.1  

    See identical proteins and their annotated locations for XP_005264557.1

    UniProtKB/Swiss-Prot
    Q9BWT3
    Conserved Domains (3) summary
    cd05402
    Location:59213
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam04926
    Location:365507
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:16364
    PAP_central; Poly(A) polymerase central domain
  2. XM_005264501.1XP_005264558.1  

    See identical proteins and their annotated locations for XP_005264558.1

    Conserved Domains (3) summary
    cd05402
    Location:15169
    NT_PAP_TUTase; Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases
    pfam04926
    Location:321463
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain
    pfam04928
    Location:1320
    PAP_central; Poly(A) polymerase central domain
  3. XM_011533041.1XP_011531343.1  

    Conserved Domains (2) summary
    PTZ00418
    Location:2316
    PTZ00418; Poly(A) polymerase; Provisional
    pfam04926
    Location:127269
    PAP_RNA-bind; Poly(A) polymerase predicted RNA binding domain

RNA

  1. XR_939713.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    60913785..60959664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)