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    ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 [ Homo sapiens ]

    Gene ID: 6487, updated on 19-May-2012
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    Summary

    Official Symbol
    ST3GAL3provided by HGNC
    Official Full Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 3provided by HGNC
    Primary source
    HGNC:10866
    See related
    Ensembl:ENSG00000126091; HPRD:05930; MIM:606494; Vega:OTTHUMG00000007561
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ST3N; MRT12; SIAT6; ST3GALII; ST3GalIII
    Summary
    The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi apparatus but can be proteolytically processed to a soluble form. This protein is a member of glycosyltransferase family 29. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    1p34.1
    Sequence :
    Chromosome: 1; NC_000001.10 (44173218..44396831)
    See ST3GAL3 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, receptor type, F Neighboring gene lysine (K)-specific demethylase 4A Neighboring gene uncharacterized LOC100132774 Neighboring gene serine hydroxymethyltransferase 1 (soluble) pseudogene 1 Neighboring gene artemin Neighboring gene importin 13

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. ST3GAL3 mutations impair the development of higher cognitive functions. Hu H, et al. Am J Hum Genet, 2011 Sep 9. PMID 21907012.
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Rose JE, et al. Mol Med, 2010 Jul-Aug. PMID 20379614.
    3. Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells. Carvalho AS, et al. Int J Biochem Cell Biol, 2010 Jan. PMID 19781661.
    4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965.
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070.

    See all (19) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. ST3GAL3 mutations impair the development of higher cognitive functions.
      Title: ST3GAL3 mutations impair the development of higher cognitive functions.
    2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    3. Expression of ST3Gal IV in several gastrointestinal cell lines is correlated with the expression of sialyl Lewis x at the cell surface.
      Title: Differential expression of alpha-2,3-sialyltransferases and alpha-1,3/4-fucosyltransferases regulates the levels of sialyl Lewis a and sialyl Lewis x in gastrointestinal carcinoma cells.
    4. High levels of ST3GAL-III in the tumor tissue correlated with secondary local tumor recurrence (p = 0.005; p = 0.012).
      Title: Clinical relevance of sialyltransferases ST6GAL-I and ST3GAL-III in gastric cancer.
    5. Characterization of the promoter region of the ST3Gal III gene.
      Title: Characterization of the promoter region of the human Galbeta1,3(4)GlcNAc alpha2,3-sialyltransferase III (hST3Gal III) gene.
    6. Identification of a new ST3Gal3 transcript from fetal brain.
      Title: Identification of seven new alpha2,3-sialyltransferase III, ST3Gal III, transcripts from human foetal brain.
    7. 19 different transcripts of ST3GalIII were isolated and cloned; tissue distribution analysis showed complex patterns in neural and muscular tissues
      Title: Cloning and sequencing of nineteen transcript isoforms of the human alpha2,3-sialyltransferase gene, ST3Gal III; its genomic organisation and expression in human tissues.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Mental retardation, autosomal recessive 12

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp160, precursor env Oligosaccharide side-chains of HIV-1 gp160 are processed by glycosidase I and II, mannosidase I and II, acetylglucosaminyl transferase I and II, and fucosyl, galactosyl and sialyl transferases in both the endoplasmic reticulum and golgi apparatus PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q11203 P63261 ACTG1    HPRD  PubMed  
    Q11203 P62917 RPL8    HPRD  PubMed  
    Q11203 O15127 SCAMP2    HPRD  PubMed  
    Q11203 P02766 TTR    HPRD  PubMed  
    Q11203 O15062 ZBTB5    HPRD  PubMed  
    BioGRID:112379 BioGRID:106586 ACTG1    BioGRID  PubMed Two-hybrid 
    BioGRID:112379 BioGRID:112052 RPL8    BioGRID  PubMed Two-hybrid 
    BioGRID:112379 BioGRID:115377 SCAMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:112379 BioGRID:115253 ZBTB5    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    N-acetyllactosaminide alpha-2,3-sialyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    O-glycan processing TAS
    Traceable Author Statement
    more info
    		  
    cellular protein metabolic process TAS
    Traceable Author Statement
    more info
    		  
    post-translational protein modification TAS
    Traceable Author Statement
    more info
    		  
    protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Golgi membrane TAS
    Traceable Author Statement
    more info
    		  
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
    Names
    CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
    ST3Gal III
    alpha 2,3-ST 3
    alpha-2,3-sialyltransferase II
    alpha 2,3-sialyltransferase III
    Gal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferase
    sialyltransferase 6 (N-acetyllacosaminide alpha 2,3-sialyltransferase)
    NP_006270.1
    NP_777623.2
    NP_777624.1
    NP_777625.1
    NP_777626.1
    NP_777627.1
    NP_777628.2
    NP_777629.1
    NP_777630.1
    NP_777631.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028196.1 RefSeqGene

      Range
      5001..228614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006279.2 → NP_006270.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (j, also called B1) is shorter compared to isoform a.
      Source sequence(s)
      AY051143, L23768
      Consensus CDS
      CCDS492.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000355341, OTTHUMP00000008811, ENST00000361392, OTTHUMT00000019964
      Conserved Domains (1) summary
      pfam00777
      Location:107 – 374
      Blast Score: 763
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    2. NM_174963.2 → NP_777623.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also called A8).
      Source sequence(s)
      AF425853, AK301829, AL357079, BC050380
      Consensus CDS
      CCDS493.1
      UniProtKB/TrEMBL
      B4DX62
      UniProtKB/Swiss-Prot
      Q11203
      Related
      ENSP00000262915, ENST00000262915
      Conserved Domains (1) summary
      pfam00777
      Location:176 – 443
      Blast Score: 765
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    3. NM_174964.1 → NP_777624.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in an isoform (b, also called A1) that is shorter compared to isoform a.
      Source sequence(s)
      AF425851, AY051143
      Consensus CDS
      CCDS494.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q5T4W8
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000317192, OTTHUMP00000008816, ENST00000347631, OTTHUMT00000019969
      Conserved Domains (1) summary
      pfam00777
      Location:122 – 389
      Blast Score: 764
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    4. NM_174965.1 → NP_777625.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (c, also called A7) has a distinct C-terminus and is shorter compared to isoform a.
      Source sequence(s)
      AF425852, AY051143
      Consensus CDS
      CCDS499.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q5T4Y1
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000439634, ENST00000545417

    5. NM_174966.1 → NP_777626.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (d, also called B4) is shorter compared to isoform a.
      Source sequence(s)
      AF425856, AY051143
      Consensus CDS
      CCDS495.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000330463, ENST00000353126
      Conserved Domains (1) summary
      pfam00777
      Location:107 – 266
      Blast Score: 449
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    6. NM_174967.1 → NP_777627.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (e, also called B7) has a distinct C-terminus and is shorter compared to isoform a.
      Source sequence(s)
      AF425857, AY051143
      Consensus CDS
      CCDS500.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000333494, ENST00000330208

    7. NM_174968.2 → NP_777628.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) utilizes an alternate in-frame splice site compared to variant 1, resulting in an isoform (f, also called B8) that is shorter compared to isoform a.
      Source sequence(s)
      AF425858, AK301829, AL357079, BC050380
      Consensus CDS
      CCDS496.1
      UniProtKB/TrEMBL
      B4DX62
      UniProtKB/Swiss-Prot
      Q11203
      Related
      ENSP00000361450, ENST00000372375
      Conserved Domains (1) summary
      pfam00777
      Location:161 – 428
      Blast Score: 764
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    8. NM_174969.1 → NP_777629.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences in the coding region but maintains the reading frame compared to variant 1. The resulting isoform (g, also called C1) is shorter compared to isoform a.
      Source sequence(s)
      AF425859, AY051143
      Consensus CDS
      CCDS497.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000354748, OTTHUMP00000008812, ENST00000361400, OTTHUMT00000019965
      Conserved Domains (1) summary
      pfam00777
      Location:91 – 358
      Blast Score: 760
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    9. NM_174970.1 → NP_777630.1  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) has multiple differences in the coding region, one of which results in a frameshift compared to variant 1. The resulting isoform (h, also called C7) has a distinct C-terminus and is shorter compared to isoform a.
      Source sequence(s)
      AF425860, AY051143
      Consensus CDS
      CCDS53310.1
      UniProtKB/Swiss-Prot
      Q11203
      UniProtKB/TrEMBL
      Q96L53
      Related
      ENSP00000435603, OTTHUMP00000231087, ENST00000531451, OTTHUMT00000019978

    10. NM_174971.2 → NP_777631.2  CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate in-frame segment compared to variant 1, resulting in an isoform (i, also called C8) that is shorter compared to isoform a.
      Source sequence(s)
      AF425861, AK301829, AL357079, BC050380
      Consensus CDS
      CCDS498.1
      UniProtKB/TrEMBL
      B4DX62
      UniProtKB/Swiss-Prot
      Q11203
      Related
      ENSP00000316999, ENST00000351035
      Conserved Domains (1) summary
      pfam00777
      Location:145 – 412
      Blast Score: 761
      Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      44173218..44396831
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      42293648..42515705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_174972.1: Suppressed sequence

      Description
      NM_174972.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL357079.24 CAI16785.1
      CAI16786.1
      CAI16787.1
      CAI16788.1
      CAI16789.1
      CAI16790.1
      CAI16791.1
      CAI16792.1
      CAI16793.1
      CAI16794.1
      CAI16795.1
      CAI16796.1
    genomic AL451062.12 CAH71022.1
      CAH71023.1
      CAH71024.1
      CAH71025.1
      CAH71026.1
      CAH71027.1
      CAH71028.1
      CAH71029.1
      CAH71030.1
      CAH71031.1
      CAH71032.1
      CAH71033.1
    genomic AL592548.10 CAI22181.1
      CAI22182.1
      CAI22183.1
      CAI22184.1
      CAI22185.1
      CAI22186.1
      CAI22187.1
      CAI22188.1
      CAI22189.1
      CAI22190.1
      CAI22191.1
      CAI22192.1
    genomic CH471059.2 EAX07082.1
      EAX07083.1
      EAX07084.1
    genomic GM603710.1 CAT03463.1
    mRNA AF425851.1 AAO13859.1
    mRNA AF425852.1 AAO13860.1
    mRNA AF425853.1 AAO13861.1
    mRNA AF425854.1 AAO13862.1
    mRNA AF425855.1 AAO13863.1
    mRNA AF425856.1 AAO13864.1
    mRNA AF425857.1 AAO13865.1
    mRNA AF425858.1 AAO13866.1
    mRNA AF425859.1 AAO13867.1
    mRNA AF425860.1 AAO13868.1
    mRNA AF425861.1 AAO13869.1
    mRNA AF425862.1 AAO13870.1
    mRNA AF425863.1 AAO13871.1
    mRNA AF425864.1 AAO13872.1
    mRNA AF425865.1 AAO13873.1
    mRNA AF425866.1 AAO13874.1
    mRNA AF425867.1 AAO13875.1
    mRNA AF425868.1 AAO13876.1
    mRNA AF425869.1 AAO13877.1
    mRNA AK301829.1 BAG63274.1
    mRNA AK310265.1 None
    mRNA AY051143.1 AAL14347.1
    mRNA AY167992.1 AAO38806.1
    mRNA AY167993.1 AAO38807.1
    mRNA AY167994.1 AAO38808.1
    mRNA AY167995.1 AAO38809.1
    mRNA AY167996.1 AAO38810.1
    mRNA AY167997.1 AAO38811.1
    mRNA AY167998.1 AAO38812.1
    mRNA BC050380.1 AAH50380.1
    mRNA L23768.1 AAA35778.1
    other-genetic HQ448581.1 ADQ33059.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q11203.1 GenPept UniProtKB/Swiss-Prot:Q11203
    Q96L53 GenPept UniProtKB/TrEMBL:Q96L53
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    Additional Links

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