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METTL4 methyltransferase like 4 [ Homo sapiens (human) ]

Gene ID: 64863, updated on 26-May-2016
Official Symbol
METTL4provided by HGNC
Official Full Name
methyltransferase like 4provided by HGNC
Primary source
HGNC:HGNC:24726
See related
Ensembl:ENSG00000101574 HPRD:14390; Vega:OTTHUMG00000131482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT661
Orthologs
Location:
18p11.32
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (2537525..2571490, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (2537524..2571489, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371962 Neighboring gene uncharacterized LOC101926997 Neighboring gene ubiquitin-conjugating enzyme E2 variant 1-like Neighboring gene NDC80, kinetochore complex component Neighboring gene katanin regulatory subunit B1 like 1 pseudogene 3 Neighboring gene chromobox 3 pseudogene 2

NHGRI GWAS Catalog

Description
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • FLJ23017, MGC117235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
methylation IEA
Inferred from Electronic Annotation
more info
 
nucleobase-containing compound metabolic process IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
methyltransferase-like protein 4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308401.1NP_001295330.1  methyltransferase-like protein 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AP005136
    Consensus CDS
    CCDS77144.1
    UniProtKB/TrEMBL
    J3KNJ7
    Conserved Domains (1) summary
    cl01947
    Location:281383
    MT-A70; MT-A70
  2. NM_022840.4NP_073751.3  methyltransferase-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_073751.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AP005136, BC111020, BU741018, HY026088
    Consensus CDS
    CCDS11826.1
    UniProtKB/Swiss-Prot
    Q8N3J2
    Related
    ENSP00000458290, OTTHUMP00000162205, ENST00000574538, OTTHUMT00000254326
    Conserved Domains (1) summary
    cl01947
    Location:281455
    MT-A70; MT-A70

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    2537525..2571490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258133.1XP_005258190.1  

    Conserved Domains (1) summary
    cl01947
    Location:134308
    MT-A70; MT-A70
  2. XM_005258132.2XP_005258189.1  

    Conserved Domains (1) summary
    cl01947
    Location:281358
    MT-A70; MT-A70
  3. XM_011525730.1XP_011524032.1  

    Conserved Domains (1) summary
    cl01947
    Location:281301
    MT-A70; MT-A70
  4. XM_006722339.2XP_006722402.1  

    Related
    ENSP00000320349, OTTHUMP00000258738, ENST00000319888, OTTHUMT00000440910
    Conserved Domains (1) summary
    cl01947
    Location:281383
    MT-A70; MT-A70

RNA

  1. XR_243813.2 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    2536901..2570862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)