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KLC2 kinesin light chain 2 [ Homo sapiens (human) ]

Gene ID: 64837, updated on 8-Feb-2015
Official Symbol
KLC2provided by HGNC
Official Full Name
kinesin light chain 2provided by HGNC
Primary source
HGNC:HGNC:20716
See related
Ensembl:ENSG00000174996; HPRD:13917; MIM:611729; Vega:OTTHUMG00000133757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Kinesin is a molecular motor that generates ATP-dependent movement of vesicles and organelles along microtubules. Kinesin consists of 2 light chains, such as KLC2, and 2 heavy chains (see KIF5B; MIM 602809) in a 1:1 stoichiometric ratio (Rahman et al., 1998 [PubMed 9624122]).[supplied by OMIM, Mar 2008]
Orthologs
See KLC2 in MapViewer
Location:
11q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (66257294..66267861)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (66024765..66035332)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 2, 145kDa Neighboring gene phosphofurin acidic cluster sorting protein 1 Neighboring gene RAB1B, member RAS oncogene family Neighboring gene cornichon family AMPA receptor auxiliary protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog
  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
    MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12387

Gene Ontology Provided by GOA

Function Evidence Code Pubs
kinesin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
microtubule motor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
Traceable Author Statement
more info
 
axon cargo transport IEA
Inferred from Electronic Annotation
more info
 
blood coagulation TAS
Traceable Author Statement
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
microtubule-based movement TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol TAS
Traceable Author Statement
more info
 
kinesin I complex NAS
Non-traceable Author Statement
more info
PubMed 
kinesin complex ISS
Inferred from Sequence or Structural Similarity
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
microtubule IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
 
Preferred Names
kinesin light chain 2
Names
kinesin light chain 2
KLC 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134774.1NP_001128246.1  kinesin light chain 2 isoform 2

    See proteins identical to NP_001128246.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon resulting in a shorter protein isoform (2) compared to variant 1. It also reflects use of an alternate splice acceptor site in exon 2.
    Source sequence(s)
    AK022907, AK094593, AP001107, BE882786, BP214296, CN310361
    Consensus CDS
    CCDS44653.1
    UniProtKB/Swiss-Prot
    Q9H0B6
    Related
    ENSP00000408484, ENST00000421552
    Conserved Domains (3) summary
    cd00189
    Location:169276
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:31162
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:159237
    TPR_12; Tetratricopeptide repeat
  2. NM_001134775.1NP_001128247.1  kinesin light chain 2 isoform 1

    See proteins identical to NP_001128247.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents an alternate 5'UTR and encodes the longer protein isoform (1). The same protein is encoded by transcript variants 1, 3, and 4.
    Source sequence(s)
    AL136864, AP001107, DA291004, DA773222
    Consensus CDS
    CCDS8130.1
    UniProtKB/Swiss-Prot
    Q9H0B6
    Related
    ENSP00000399403, ENST00000417856
    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC
  3. NM_001134776.1NP_001128248.1  kinesin light chain 2 isoform 1

    See proteins identical to NP_001128248.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents an alternate 5'UTR and encodes the longer protein isoform (1). The same protein is encoded by transcript variants 1, 3, and 4.
    Source sequence(s)
    AL136864, AP001107, DA198727, DB136312
    Consensus CDS
    CCDS8130.1
    UniProtKB/Swiss-Prot
    Q9H0B6
    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC
  4. NM_022822.2NP_073733.1  kinesin light chain 2 isoform 1

    See proteins identical to NP_073733.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents an alternate 5'UTR and encodes the longer protein isoform (1). The same protein is encoded by transcript variants 1, 3, and 4.
    Source sequence(s)
    AK022907, AL136864, AP001107, BP214296
    Consensus CDS
    CCDS8130.1
    UniProtKB/Swiss-Prot
    Q9H0B6
    Related
    ENSP00000314837, OTTHUMP00000165216, ENST00000316924, OTTHUMT00000258200
    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38 Primary Assembly

    Range
    66257294..66267861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005274183.1XP_005274240.1  

    See proteins identical to XP_005274240.1

    UniProtKB/Swiss-Prot
    Q9H0B6
    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC
  2. XM_005274182.1XP_005274239.1  

    See proteins identical to XP_005274239.1

    UniProtKB/Swiss-Prot
    Q9H0B6
    Related
    ENSP00000377631, OTTHUMP00000165218, ENST00000394067, OTTHUMT00000258202
    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC
  3. XM_005274184.1XP_005274241.1  

    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC
  4. XM_006718665.1XP_006718728.1  

    Conserved Domains (4) summary
    cd00189
    Location:242353
    TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
    pfam09311
    Location:69239
    Rab5-bind; Rabaptin-like protein
    pfam13424
    Location:236314
    TPR_12; Tetratricopeptide repeat
    cl19252
    Location:76149
    MreC; rod shape-determining protein MreC

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    65908861..65919431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000143.1 Alternate HuRef

    Range
    62350277..62360839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)