BMI1 BMI1 polycomb ring finger oncogene [Homo sapiens] - Gene

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Summary

Official Symbol: BMI1provided by HGNC
Official Full Name: BMI1 polycomb ring finger oncogeneprovided by HGNC
Primary source: HGNC:1066
Locus tag: RP11-573G6.1
See related: Ensembl:ENSG00000168283; HPRD:01277; MIM:164831; Vega:OTTHUMG00000017807
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PCGF4; RNF51; FLVI2/BMI1; MGC12685

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Genomic context

Location :: 10p11.23

Sequence :: Chromosome: 10; NC_000010.10 (22610139..22620414)

See BMI1 in Epigenomics, MapViewer

Chromosome 10 - NC_000010.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bmi1 expression profiles show a marked elevation in the proneural glioblastoma subtype.
Title: Bmi1 marks intermediate precursors during differentiation of human brain tumor initiating cells.
ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer.
Title: Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study.
Results suggest that Bmi1 plays a crucial role in the maintenance of the stem cell pool in postnatal skeletal muscle and is essential for efficient muscle regeneration after injury especially after repeated muscle injury.
Title: Bmi1 is expressed in postnatal myogenic satellite cells, controls their maintenance and plays an essential role in repeated muscle regeneration.
It has been clearly established that BMI1 is a bonafide oncogene and plays critical roles in promoting cancer stem cell self-renewal and tumorogenesis.
Title: BMI1 as a novel target for drug discovery in cancer.
Data indicate that the dynamics of recognition of UV-damaged chromatin, and the nuclear arrangement of BMI1 protein can be influenced by acetylation and occur as an early event prior to the recruitment of HPbeta to UV-irradiated chromatin.
Title: Acetylation-dependent nuclear arrangement and recruitment of BMI1 protein to UV-damaged chromatin.
Measuring BMI-1 autoantibody levels of patients with cervical cancer could have clinical prognostic value as well as a non-tissue specific biomarker for neoplasms expressing BMI-1.
Title: BMI-1 autoantibody as a new potential biomarker for cervical carcinoma.
Regulation of the potential marker for intestinal cells, Bmi1, by beta-catenin and the zinc finger protein KLF4: implications for colon cancer.
Title: Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancer.
knockdown of BMI-1 expression can induce cell-cycle arrest and up-regulate p16INK4a, HOXA9 and HOXC13 in HeLa cells
Title: Knockdown of BMI-1 causes cell-cycle arrest and derepresses p16INK4a, HOXA9 and HOXC13 mRNA expression in HeLa cells.
correlated the expression of miR-200b, miR-15b and BMI1 with the clinicopathological status and prognosis of tongue squamous cell carcinoma patients
Title: MiR-200b and miR-15b regulate chemotherapy-induced epithelial-mesenchymal transition in human tongue cancer cells by targeting BMI1.
Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome.
Title: Overexpression of BMI1 confers clonal cells resistance to apoptosis and contributes to adverse prognosis in myelodysplastic syndrome.

Submit: New GeneRIF Correction See all (160)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_005171.4	NP_005171.4	BMI1	BIND	PubMed	BMI1 forms a homodimer.
NP_005171.4	AAP36016.1	RING1	BIND	PubMed	RING1 interacts with BMI1.
P35226	P35226	BMI1	HPRD	PubMed
P35226	Q9HC52	CBX8	HPRD	PubMed
P35226	E2F transcription factor 6	E2F6	HPRD	PubMed
P35226	Q16891	IMMT	HPRD	PubMed
P35226	Q92993	KAT5	HPRD	PubMed
P35226	Q9P2H0	KIAA1377	HPRD	PubMed
P35226	Q5T3J3	LRIF1	HPRD	PubMed
P35226	NP_004626.1	MAPKAPK3	BIND	PubMed	3pK interacts with and phosphorylates Bmi1.
P35226	Q03164	MLL	HPRD	PubMed
P35226	NP_004417.1	PHC1	BIND	PubMed	HPH1 interacts with Bmi1.
P35226	P78364	PHC1	HPRD	PubMed
P35226	Q8IXK0	PHC2	HPRD	PubMed
P35226	P21246	PTN	HPRD	PubMed
P35226	Q06587	RING1	HPRD	PubMed
P35226	NP_009143.1	RNF2	BIND	PubMed	Rnf2 interacts with Bmi1.
P35226	Q99496	RNF2	HPRD	PubMed
P35226	Q05516	ZBTB16	HPRD	PubMed
BioGRID:107116	BioGRID:106962	ATM	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:107116	BMI1	BioGRID	PubMed	Reconstituted Complex
BioGRID:107116	BioGRID:114457	BTRC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:124228	CBX2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107116	BioGRID:114105	CBX4	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex
BioGRID:107116	BioGRID:117044	CBX7	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107116	BioGRID:121487	CBX8	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:107116	BioGRID:107426	CDC6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:107487	CENPA	BioGRID	PubMed	Co-purification
BioGRID:107116	BioGRID:114030	CUL3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:198535	Cbx2	BioGRID	PubMed	Affinity Capture-MS; Co-purification
BioGRID:107116	BioGRID:108208	E2F6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:108596	FOXS1	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:108895	GATA3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:109268	H2AFX	BioGRID	PubMed	Co-localization
BioGRID:107116	BioGRID:113933	HIST2H2AA3	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:107116	BioGRID:113934	HIST2H2AC	BioGRID	PubMed	Biochemical Activity
BioGRID:107116	BioGRID:116185	IMMT	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:115779	KAT5	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:121617	KIAA1377	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:120905	LRIF1	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:110443	MLL	BioGRID	PubMed	Reconstituted Complex
BioGRID:107116	BioGRID:106652	PARP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:108233	PHC1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:107116	BioGRID:108234	PHC2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-fractionation
BioGRID:107116	BioGRID:123068	PHC3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:107116	BioGRID:111577	PRKDC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:111731	PTN	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:111947	RING1	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid
BioGRID:107116	BioGRID:111972	RNF2	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western; Co-crystal Structure; Co-purification; Reconstituted Complex
BioGRID:107116	BioGRID:113993	SPOP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:113006	TOP2A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:113171	UBE2D3	BioGRID	PubMed	Reconstituted Complex
BioGRID:107116	BioGRID:113177	UBE2I	BioGRID	PubMed	Two-hybrid
BioGRID:107116	BioGRID:113866	USP11	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107116	BioGRID:113622	USP7	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:107116	BioGRID:113353	XRCC5	BioGRID	PubMed	Affinity Capture-Western
BioGRID:107116	BioGRID:113498	ZBTB16	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Function	Evidence Code	Pubs
RING-like zinc finger domain binding	IPI Inferred from Physical Interaction more info	PubMed
chromatin binding	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info
ubiquitin-protein ligase activity	IEA Inferred from Electronic Annotation more info
zinc ion binding	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
brain development	IEA Inferred from Electronic Annotation more info
chromatin modification	IEA Inferred from Electronic Annotation more info
embryonic skeletal system morphogenesis	IEA Inferred from Electronic Annotation more info
hemopoiesis	IEP Inferred from Expression Pattern more info	PubMed
histone acetylation	IEA Inferred from Electronic Annotation more info
histone ubiquitination	IEA Inferred from Electronic Annotation more info
humoral immune response	IEA Inferred from Electronic Annotation more info
in utero embryonic development	IEA Inferred from Electronic Annotation more info
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IEA Inferred from Electronic Annotation more info
negative regulation of transcription from RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of B cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of fibroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
positive regulation of ubiquitin-protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info
rostrocaudal neural tube patterning	IEA Inferred from Electronic Annotation more info
segment specification	TAS Traceable Author Statement more info	PubMed
somatic stem cell division	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
PcG protein complex	IDA Inferred from Direct Assay more info
PcG protein complex	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
nuclear body	IEA Inferred from Electronic Annotation more info
nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
ubiquitin ligase complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: polycomb complex protein BMI-1

Names: polycomb complex protein BMI-1; flvi-2/bmi-1; ring finger protein 51; polycomb group protein Bmi1; polycomb group RING finger protein 4; B lymphoma Mo-MLV insertion region 1 homolog; murine leukemia viral (bmi-1) oncogene homolog

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005180.8 → NP_005171.4 polycomb complex protein BMI-1

Status: VALIDATED

Source sequence(s)

AI274830, BC011652, BE008203, DB225488

Consensus CDS

CCDS7138.1

UniProtKB/Swiss-Prot

P35226

Related

ENSP00000365851, OTTHUMP00000019290, ENST00000376663, OTTHUMT00000047176

Conserved Domains (2) summary

cd00162
Location:17 – 56
Blast Score: 114

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

COG5432
Location:4 – 168
Blast Score: 95

RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000010.10 Reference GRCh37.p5 Primary Assembly

Range

22610139..22620414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000142.1 Alternate HuRef

Range

22276563..22281617

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL158211.29	CAI15954.1
		CAI15955.1
		CAI15956.1
		CAI15957.1
		CAI15958.1
		CAI15959.1
genomic	CH471072.2	EAW86148.1
		EAW86150.1
		EAW86151.1
		EAW86154.1
mRNA	AI274830.1	None
mRNA	BC011652.2	AAH11652.1
mRNA	BE008203.1	None
mRNA	BT019450.1	AAV38257.1
mRNA	CR456911.1	CAG33192.1
mRNA	DB161566.1	None
mRNA	DB225488.1	None
mRNA	L13689.1	AAA19873.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P35226.2	GenPept	UniProtKB/Swiss-Prot:P35226
Q5T8Z1	GenPept	UniProtKB/TrEMBL:Q5T8Z1
Q5T8Z2	GenPept	UniProtKB/TrEMBL:Q5T8Z2
Q5T8Z4	GenPept	UniProtKB/TrEMBL:Q5T8Z4
Q5T8Z5	GenPept	UniProtKB/TrEMBL:Q5T8Z5
Q5T8Z6	GenPept	UniProtKB/TrEMBL:Q5T8Z6
Q5U0M5	GenPept	UniProtKB/TrEMBL:Q5U0M5
Q6IB93	GenPept	UniProtKB/TrEMBL:Q6IB93