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RBM15 RNA binding motif protein 15 [ Homo sapiens (human) ]

Gene ID: 64783, updated on 8-May-2016
Official Symbol
RBM15provided by HGNC
Official Full Name
RNA binding motif protein 15provided by HGNC
Primary source
HGNC:HGNC:14959
See related
Ensembl:ENSG00000162775 HPRD:05832; MIM:606077; Vega:OTTHUMG00000011284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OTT; OTT1; SPEN
Summary
Members of the SPEN (Split-end) family of proteins, including RBM15, have repressor function in several signaling pathways and may bind to RNA through interaction with spliceosome components (Hiriart et al., 2005 [PubMed 16129689]).[supplied by OMIM, Feb 2009]
Orthologs
Location:
1p13
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (110338426..110373218)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110881945..110889303)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene KCNC4 antisense RNA 1 (head to head) Neighboring gene potassium voltage-gated channel subfamily C member 4 Neighboring gene uncharacterized LOC440600 Neighboring gene solute carrier family 16 member 4 Neighboring gene LAMTOR5 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene prokineticin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag NXF1 upregulates the RBM15-mediated Gag expression from pNLgag-RTE, suggesting cooperation between RBM15 and NXF1 PubMed
Rev rev HIV-1 Rev interacting protein, RNA binding motif protein 15 (RBM15), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with RBM15 is increased by RRE PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12479, FLJ21943, MGC119584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
nucleic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of myeloid cell differentiation IEA
Inferred from Electronic Annotation
more info
 
NOT negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
patterning of blood vessels IEA
Inferred from Electronic Annotation
more info
 
placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription of Notch receptor target IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear membrane IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
putative RNA-binding protein 15
Names
RNA-binding motif protein 15
one twenty two protein
one twenty-two
one-twenty two protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201545.1NP_001188474.1  putative RNA-binding protein 15 isoform 2

    See identical proteins and their annotated locations for NP_001188474.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct C-terminus when it is compared to isoform 1.
    Source sequence(s)
    AF368062, AI863760, BC006397, BC098140
    Consensus CDS
    CCDS59198.1
    UniProtKB/Swiss-Prot
    Q96T37
    Related
    ENSP00000473552, OTTHUMP00000272368, ENST00000487146, OTTHUMT00000035930
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  2. NM_022768.4NP_073605.4  putative RNA-binding protein 15 isoform 1

    See identical proteins and their annotated locations for NP_073605.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AW173262, BC042587, BC047479, BC062316
    Consensus CDS
    CCDS822.1
    UniProtKB/Swiss-Prot
    Q96T37
    Related
    ENSP00000483133, ENST00000618772
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    110338426..110373218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011541969.1XP_011540271.1  

    See identical proteins and their annotated locations for XP_011540271.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  2. XM_011541964.1XP_011540266.1  

    See identical proteins and their annotated locations for XP_011540266.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  3. XM_011541966.1XP_011540268.1  

    See identical proteins and their annotated locations for XP_011540268.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  4. XM_011541965.1XP_011540267.1  

    See identical proteins and their annotated locations for XP_011540267.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  5. XM_011541967.1XP_011540269.1  

    See identical proteins and their annotated locations for XP_011540269.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain
  6. XM_011541968.1XP_011540270.1  

    See identical proteins and their annotated locations for XP_011540270.1

    UniProtKB/Swiss-Prot
    Q96T37
    Conserved Domains (5) summary
    smart00360
    Location:375446
    RRM; RNA recognition motif
    cd12553
    Location:169251
    RRM1_RBM15; RNA recognition motif 1 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12555
    Location:367453
    RRM2_RBM15; RNA recognition motif 2 in vertebrate RNA binding motif protein 15 (RBM15)
    cd12557
    Location:456528
    RRM3_RBM15; RNA recognition motif 3 in vertebrate RNA binding motif protein 15 (RBM15)
    pfam07744
    Location:788924
    SPOC; SPOC domain

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    110997290..111004648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)