These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in this
section to the one reported in Genomic regions, transcripts, and products above.
Genomic
-
NG_029599.1 RefSeqGene
- Range
- 5001..29788
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
-
NM_001006610.1 → NP_001006611.1 E3 ubiquitin-protein ligase SIAH1 isoform b
Status: REVIEWED
- Description
- Transcript Variant: This variant (2) includes an alternate 5' exon and uses an upstream AUG compared to variant 1. The resulting protein (isoform b) is longer and has a distinct N-terminus compared to isoform a.
- Source sequence(s)
-
BC042550, BX357983, BX647064, CN360509
- Consensus CDS
-
CCDS32444.1
- UniProtKB/Swiss-Prot
-
Q8IUQ4
- Related
- ENSP00000349156, OTTHUMP00000164188, ENST00000356721, OTTHUMT00000256840
- Conserved Domains (3) summary
-
- cd03829
Location:186 – 312
Blast Score: 609
- Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
- pfam03145
Location:113 – 309
Blast Score: 770
- Sina; Seven in absentia protein family
- pfam13923
Location:70 – 107
Blast Score: 91
- zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
-
NM_003031.3 → NP_003022.3 E3 ubiquitin-protein ligase SIAH1 isoform a
Status: REVIEWED
- Description
- Transcript Variant: This variant (1) encodes the smaller isoform (1).
- Source sequence(s)
-
BC018193, BC035562
- Consensus CDS
-
CCDS10735.1
- UniProtKB/Swiss-Prot
-
Q8IUQ4
- Related
- ENSP00000378214, OTTHUMP00000164189, ENST00000394725, OTTHUMT00000256841
- Conserved Domains (3) summary
-
- cd03829
Location:155 – 281
Blast Score: 606
- Sina; Seven in absentia (Sina) protein family, C-terminal substrate binding domain; composed of the Drosophila Sina protein, the mammalian Sina homolog (Siah), the plant protein SINAT5, and similar proteins. Sina, Siah and SINAT5 are RING-containing proteins ...
- pfam03145
Location:82 – 278
Blast Score: 767
- Sina; Seven in absentia protein family
- pfam13923
Location:39 – 76
Blast Score: 90
- zf-C3HC4_2; Zinc finger, C3HC4 type (RING finger)
The following sections contain reference sequences that belong to a
specific genome build. Explain
This section includes genomic Reference
Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs
for chromosomes and scaffolds (contigs) from both reference and alternate assemblies.
Model RNAs and proteins are also reported here.
Reference GRCh37.p5 Primary Assembly
Genomic
-
NC_000016.9 Reference GRCh37.p5 Primary Assembly
- Range
- 48394442..48419229, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)
Alternate HuRef
Genomic
-
AC_000148.1 Alternate HuRef
- Range
- 34285181..34290523, complement
- Download
- GenBank, FASTA, Sequence Viewer (Graphics)