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    MEAF6 MYST/Esa1-associated factor 6 [ Homo sapiens ]

    Gene ID: 64769, updated on 11-May-2012
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    Summary

    Official Symbol
    MEAF6provided by HGNC
    Official Full Name
    MYST/Esa1-associated factor 6provided by HGNC
    Primary source
    HGNC:25674
    Locus tag
    RP3-423B22.2
    See related
    Ensembl:ENSG00000163875; HPRD:13347; MIM:611001; Vega:OTTHUMG00000004223
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Eaf6; CENP-28; C1orf149; CDABP0189; NY-SAR-91; RP3-423B22.2; FLJ11730
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    Genomic context

    Location :
    1p35.3-p33
    Sequence :
    Chromosome: 1; NC_000001.10 (37958176..37980364, complement)
    See MEAF6 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC728431 Neighboring gene zinc finger CCCH-type containing 12A Neighboring gene Smad nuclear interacting protein 1 Neighboring gene ferritin, heavy polypeptide 1 pseudogene Neighboring gene ribosomal protein S27 pseudogene 9

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation. Avvakumov N, et al. Mol Cell Biol, 2012 Feb. PMID 22144582.
    2. System-wide changes to SUMO modifications in response to heat shock. Golebiowski F, et al. Sci Signal, 2009 May 26. PMID 19471022.
    3. In vitro nuclear interactome of the HIV-1 Tat protein. Gautier VW, et al. Retrovirology, 2009 May 19. PMID 19454010.
    4. HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Saksouk N, et al. Mol Cell, 2009 Jan 30. PMID 19187766.
    5. An empirical framework for binary interactome mapping. Venkatesan K, et al. Nat Methods, 2009 Jan. PMID 19060904.

    See all (24) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q9HAF1 Q9NV56 C20orf20    HPRD  PubMed  
    Q9HAF1 Q15834 CCDC85B    HPRD  PubMed  
    Q9HAF1 P51116 FXR2    HPRD  PubMed  
    Q9HAF1 Q969R5 L3MBTL2    HPRD  PubMed  
    BioGRID:122280 BioGRID:113614 BRPF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:122280 BioGRID:120548 C20orf20    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122280 BioGRID:116198 CCDC85B    BioGRID  PubMed Two-hybrid 
    BioGRID:122280 BioGRID:114890 FXR2    BioGRID  PubMed Two-hybrid 
    BioGRID:122280 BioGRID:120041 ING3    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:122280 BioGRID:119331 ING4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122280 BioGRID:124016 ING5    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:122280 BioGRID:115779 KAT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122280 BioGRID:113703 KAT6A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:122280 BioGRID:116315 KAT7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122280 BioGRID:123753 L3MBTL2    BioGRID  PubMed Two-hybrid 
    BioGRID:122280 BioGRID:123029 PHF17    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:122280 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:122280 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone H2A acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H3-K14 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K12 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT histone H4-K16 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K5 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    histone H4-K8 acetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NuA4 histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    chromatin modification-related protein MEAF6
    Names
    chromatin modification-related protein MEAF6
    hEAF6
    protein EAF6 homolog
    centromere protein 28
    sarcoma antigen NY-SAR-91
    esa1-associated factor 6 homolog
    Esa1p-associated factor 6 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022756.4 → NP_073593.2  chromatin modification-related protein MEAF6

      Status: PROVISIONAL

      Source sequence(s)
      BX640719
      Consensus CDS
      CCDS418.1
      UniProtKB/Swiss-Prot
      Q9HAF1
      Related
      ENSP00000362166, OTTHUMP00000004402, ENST00000373075, OTTHUMT00000012162
      Conserved Domains (1) summary
      pfam09340
      Location:16 – 89
      Blast Score: 218
      NuA4; Histone acetyltransferase subunit NuA4

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      37958176..37980364, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      36075222..36097146, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL034379.8 CAI20547.1
      CAI20548.1
      CAI20549.1
      CAI20550.1
    genomic CH471059.2 EAX07339.1
      EAX07340.1
      EAX07341.1
      EAX07342.1
      EAX07343.1
      EAX07344.1
    mRNA AK021792.1 BAB13898.1
    mRNA AK225434.1 None
    mRNA AK225598.1 None
    mRNA AK308118.1 None
    mRNA AK309663.1 None
    mRNA AY007166.1 None
    mRNA AY211926.1 AAO65179.1
    mRNA BC016328.1 AAH16328.1
    mRNA BC043239.1 None
    mRNA BC056406.1 AAH56406.1
    mRNA BX538212.1 CAD98071.1
    mRNA BX640719.1 CAE45838.1
    mRNA DQ099384.1 AAZ13760.1
    other-genetic EU831681.1 ACE86515.1
    other-genetic EU832519.1 ACE87691.1
    other-genetic EU832600.1 ACE87002.1
    other-genetic HQ448659.1 ADQ33137.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HAF1.1 GenPept UniProtKB/Swiss-Prot:Q9HAF1
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
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