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IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase [ Homo sapiens (human) ]

Gene ID: 64768, updated on 11-Sep-2014
Official Symbol
IPPKprovided by HGNC
Official Full Name
inositol 1,3,4,5,6-pentakisphosphate 2-kinaseprovided by HGNC
Primary source
HGNC:HGNC:14645
See related
Ensembl:ENSG00000127080; HPRD:10799; Vega:OTTHUMG00000020231
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP5K; IPK1; C9orf12; INSP5K2; bA476B13.1
Summary
The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]
See IPPK in Epigenomics, MapViewer
Location:
9q22.31
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 9 NC_000009.12 (92613184..92670265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95375466..95432547, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene asporin Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene microRNA 4670 Neighboring gene uncharacterized LOC100128361 Neighboring gene ribosomal protein L21 pseudogene 86 Neighboring gene bicaudal D homolog 2 (Drosophila)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13163, KIAA0699

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
inositol pentakisphosphate 2-kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
inositol phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intracellular IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
inositol-pentakisphosphate 2-kinase
Names
inositol-pentakisphosphate 2-kinase
IPK1 homolog
insP5 2-kinase
ins(1,3,4,5,6)P5 2-kinase
bA476B13.1 (novel protein)
NP_073592.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027879.1 

    Range
    5001..62082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_022755.5NP_073592.1  inositol-pentakisphosphate 2-kinase

    See proteins identical to NP_073592.1

    Status: REVIEWED

    Source sequence(s)
    AL157827, BC026154
    Consensus CDS
    CCDS6699.1
    UniProtKB/Swiss-Prot
    Q9H8X2
    Related
    ENSP00000287996, OTTHUMP00000021662, ENST00000287996, OTTHUMT00000053101
    Conserved Domains (1) summary
    pfam06090
    Location:13458
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000009.12 

    Range
    92613184..92670265
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717235.1XP_006717298.1  

    Conserved Domains (1) summary
    pfam06090
    Location:13230
    Ins_P5_2-kin; Inositol-pentakisphosphate 2-kinase

Alternate HuRef

Genomic

  1. AC_000141.1 

    Range
    65053819..65110851
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 

    Range
    95521868..95578933
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)