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COPS7B COP9 signalosome subunit 7B [ Homo sapiens (human) ]

Gene ID: 64708, updated on 8-May-2016
Official Symbol
COPS7Bprovided by HGNC
Official Full Name
COP9 signalosome subunit 7Bprovided by HGNC
Primary source
HGNC:HGNC:16760
See related
Ensembl:ENSG00000144524 HPRD:09889; MIM:616010; Vega:OTTHUMG00000133228
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN7B; SGN7b
Orthologs
Location:
2q37.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (231781671..231809254)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (232646388..232673958)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 1244-1 Neighboring gene prothymosin, alpha Neighboring gene phosphodiesterase 6D Neighboring gene ribosomal protein L28 pseudogene 2 Neighboring gene guanidinoacetate N-methyltransferase pseudogene 1 Neighboring gene microRNA 1471

NHGRI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog
  • DNA Damage Recognition in GG-NER, organism-specific biosystem (from REACTOME)
    DNA Damage Recognition in GG-NER, organism-specific biosystemIn global genome nucleotide excision repair (GG-NER), the DNA damage is recognized by two protein complexes. The first complex consists of XPC, RAD23A or RAD23B, and CETN2. This complex probes the DN...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Formation of TC-NER Pre-Incision Complex, organism-specific biosystem (from REACTOME)
    Formation of TC-NER Pre-Incision Complex, organism-specific biosystemFormation of TC-NER pre-incision complex is initiated when the RNA polymerase II (RNA Pol II) complex stalls at a DNA damage site. The stalling is caused by misincorporation of a ribonucleotide oppos...
  • Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystem (from REACTOME)
    Global Genome Nucleotide Excision Repair (GG-NER), organism-specific biosystemThe DNA damage in GG-NER is recognized by the joint action of two protein complexes. The first complex is composed of XPC, RAD23A or RAD23B and CETN2. The second complex, known as the UV-DDB complex,...
  • Nucleotide Excision Repair, organism-specific biosystem (from REACTOME)
    Nucleotide Excision Repair, organism-specific biosystemNucleotide excision repair (NER) was first described in the model organism E. coli in the early 1960s as a process whereby bulky base damage is enzymatically removed from DNA, facilitating the recove...
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystem (from REACTOME)
    Transcription-Coupled Nucleotide Excision Repair (TC-NER), organism-specific biosystemDNA damage in transcribed strands of active genes is repaired through a specialized nucleotide excision repair (NER) pathway known as transcription-coupled nucleotide excision repair (TC-NER). TC-NER...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12612, MGC111077

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cullin deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
COP9 signalosome complex subunit 7b
Names
COP9 constitutive photomorphogenic homolog subunit 7B
JAB1-containing signalosome subunit 7b
signalosome subunit 7b

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282949.2NP_001269878.1  COP9 signalosome complex subunit 7b isoform c

    See identical proteins and their annotated locations for NP_001269878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (c) has distinct N- and C-termini and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK307486, BE504900, DA754035
    Consensus CDS
    CCDS63152.1
    UniProtKB/TrEMBL
    J3KQ34
    Related
    ENSP00000386438, OTTHUMP00000204226, ENST00000409295, OTTHUMT00000331907
    Conserved Domains (1) summary
    pfam01399
    Location:28121
    PCI; PCI domain
  2. NM_001282950.2NP_001269879.1  COP9 signalosome complex subunit 7b isoform a

    See identical proteins and their annotated locations for NP_001269879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform (a).
    Source sequence(s)
    AA126041, AC073476, BC091493, BE504900, HY051259
    Consensus CDS
    CCDS63153.1
    UniProtKB/Swiss-Prot
    Q9H9Q2
    Related
    ENSP00000362710, OTTHUMP00000164301, ENST00000373608, OTTHUMT00000256965
    Conserved Domains (1) summary
    pfam01399
    Location:62155
    PCI; PCI domain
  3. NM_001282951.2NP_001269880.1  COP9 signalosome complex subunit 7b isoform d

    See identical proteins and their annotated locations for NP_001269880.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks two exons that result in the loss of an in-frame segment in the 5' coding region, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, BE504900, BI906506, DA754035
    Consensus CDS
    CCDS74668.1
    UniProtKB/TrEMBL
    A0A087X1P5
    Related
    ENSP00000484363, ENST00000611614
    Conserved Domains (1) summary
    smart00753
    Location:46122
    PAM; PCI/PINT associated module
  4. NM_001282952.2NP_001269881.1  COP9 signalosome complex subunit 7b isoform e

    See identical proteins and their annotated locations for NP_001269881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks a portion of the 5' coding region, initiates translation at a downstream in-frame start codon, and lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AA126041, AC073476, AK024273, BE504900, HY051259
    Consensus CDS
    CCDS63154.1
    UniProtKB/Swiss-Prot
    Q9H9Q2
    UniProtKB/TrEMBL
    A0A024R478
    Related
    ENSP00000484579, ENST00000620578
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  5. NM_001308381.1NP_001295310.1  COP9 signalosome complex subunit 7b isoform f

    See identical proteins and their annotated locations for NP_001295310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice acceptor site in the central coding region, compared to variant 1. The encoded isoform (f) has the same N- and C-termini, but is longer than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK126326, BE504900, BX333333, HY051259
    Consensus CDS
    CCDS77539.1
    UniProtKB/TrEMBL
    J3KQ41, Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:88177
    PAM; PCI/PINT associated module
  6. NM_022730.3NP_073567.1  COP9 signalosome complex subunit 7b isoform b

    See identical proteins and their annotated locations for NP_073567.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon that results in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA126041, AC073476, AK022674, BE504900, HY051259
    Consensus CDS
    CCDS2488.1
    UniProtKB/Swiss-Prot
    Q9H9Q2
    UniProtKB/TrEMBL
    A0A024R471
    Related
    ENSP00000272995, OTTHUMP00000164300, ENST00000350033, OTTHUMT00000256964
    Conserved Domains (1) summary
    pfam01399
    Location:62155
    PCI; PCI domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    231781671..231809254
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712693.1XP_006712756.1  

    See identical proteins and their annotated locations for XP_006712756.1

    UniProtKB/TrEMBL
    J3KQ41
    Conserved Domains (1) summary
    smart00753
    Location:88177
    PAM; PCI/PINT associated module
  2. XM_011511640.1XP_011509942.1  

    See identical proteins and their annotated locations for XP_011509942.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  3. XM_011511639.1XP_011509941.1  

    See identical proteins and their annotated locations for XP_011509941.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  4. XM_006712692.2XP_006712755.1  

    Related
    ENSP00000386880, OTTHUMP00000204231, ENST00000410017, OTTHUMT00000331915
    Conserved Domains (1) summary
    smart00753
    Location:88177
    PAM; PCI/PINT associated module
  5. XM_011511638.1XP_011509940.1  

    See identical proteins and their annotated locations for XP_011509940.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  6. XM_011511642.1XP_011509944.1  

    See identical proteins and their annotated locations for XP_011509944.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  7. XM_011511641.1XP_011509943.1  

    See identical proteins and their annotated locations for XP_011509943.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module
  8. XM_011511643.1XP_011509945.1  

    See identical proteins and their annotated locations for XP_011509945.1

    UniProtKB/TrEMBL
    Q6ZTQ7
    Conserved Domains (1) summary
    smart00753
    Location:270
    PAM; PCI/PINT associated module

RNA

  1. XR_922986.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    232652198..232679777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)