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GPR135 G protein-coupled receptor 135 [ Homo sapiens (human) ]

Gene ID: 64582, updated on 8-May-2016
Official Symbol
GPR135provided by HGNC
Official Full Name
G protein-coupled receptor 135provided by HGNC
Primary source
HGNC:HGNC:19991
See related
Ensembl:ENSG00000181619 HPRD:16263; MIM:607970
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUMNPIIY20
Orthologs
Location:
14q23.1
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 14 NC_000014.9 (59452773..59465396, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (59930240..59932059, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene peptidylprolyl isomerase A pseudogene 5 Neighboring gene dishevelled associated activator of morphogenesis 1 Neighboring gene trans-L-3-hydroxyproline dehydratase Neighboring gene JNK1/MAPK8-associated membrane protein Neighboring gene coiled-coil domain containing 175

Protein interactions

Protein Gene Interaction Pubs
Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of G protein-coupled receptor 135 (GPR135) in U-937 macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
probable G-protein coupled receptor 135

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022571.5NP_072093.2  probable G-protein coupled receptor 135

    See identical proteins and their annotated locations for NP_072093.2

    Status: VALIDATED

    Source sequence(s)
    AY288418, BC032831, BX094623
    Consensus CDS
    CCDS9738.1
    UniProtKB/Swiss-Prot
    Q8IZ08
    Related
    ENSP00000378548, OTTHUMP00000179032, ENST00000395116, OTTHUMT00000276941
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p2 Primary Assembly

    Range
    59452773..59465396 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537096.1XP_011535398.1  

    See identical proteins and their annotated locations for XP_011535398.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011537094.1XP_011535396.1  

    See identical proteins and their annotated locations for XP_011535396.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Related
    ENSP00000432696, OTTHUMP00000233356, ENST00000481661, OTTHUMT00000276940
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011537098.1XP_011535400.1  

    See identical proteins and their annotated locations for XP_011535400.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011537095.1XP_011535397.1  

    See identical proteins and their annotated locations for XP_011535397.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_011537092.1XP_011535394.1  

    See identical proteins and their annotated locations for XP_011535394.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  6. XM_011537093.1XP_011535395.1  

    See identical proteins and their annotated locations for XP_011535395.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  7. XM_011537091.1XP_011535393.1  

    See identical proteins and their annotated locations for XP_011535393.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  8. XM_011537097.1XP_011535399.1  

    See identical proteins and their annotated locations for XP_011535399.1

    UniProtKB/Swiss-Prot
    Q8IZ08
    Conserved Domains (1) summary
    pfam00001
    Location:127387
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 Alternate CHM1_1.1

    Range
    59868393..59870212 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)