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CLEC7A C-type lectin domain family 7 member A [ Homo sapiens (human) ]

Gene ID: 64581, updated on 22-May-2016
Official Symbol
CLEC7Aprovided by HGNC
Official Full Name
C-type lectin domain family 7 member Aprovided by HGNC
Primary source
HGNC:HGNC:14558
See related
Ensembl:ENSG00000172243 HPRD:08396; MIM:606264; Vega:OTTHUMG00000133597
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12
Summary
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (10116777..10130273, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (10269376..10282868, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 1 member A Neighboring gene uncharacterized LOC105369655 Neighboring gene heterogeneous nuclear ribonucleoprotein A/B pseudogene 1 Neighboring gene oxidized low density lipoprotein receptor 1 Neighboring gene transmembrane protein 52B Neighboring gene GABA type A receptor associated protein like 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • C-type lectin receptors (CLRs), organism-specific biosystem (from REACTOME)
    C-type lectin receptors (CLRs), organism-specific biosystemPathogen recognition is central to the induction of T cell differentiation. Groups of pathogens share similar structures known as pathogen-associated molecular patterns (PAMPs), which are recognised ...
  • CLEC7A (Dectin-1) signaling, organism-specific biosystem (from REACTOME)
    CLEC7A (Dectin-1) signaling, organism-specific biosystemCLEC7A (also known as Dectin-1) is a pattern-recognition receptor (PRR) expressed by myeloid cells (macrophages, dendritic cells and neutrophils) that detects pathogens by binding to beta-1,3-glucans...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Phagosome, organism-specific biosystem (from KEGG)
    Phagosome, organism-specific biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Phagosome, conserved biosystem (from KEGG)
    Phagosome, conserved biosystemPhagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is...
  • Tuberculosis, organism-specific biosystem (from KEGG)
    Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
  • Tuberculosis, conserved biosystem (from KEGG)
    Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC protein binding NAS
Non-traceable Author Statement
more info
PubMed 
carbohydrate binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
T cell activation TAS
Traceable Author Statement
more info
PubMed 
carbohydrate mediated signaling TAS
Traceable Author Statement
more info
PubMed 
cell recognition IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to molecule of fungal origin IEA
Inferred from Electronic Annotation
more info
 
defense response to protozoan NAS
Non-traceable Author Statement
more info
PubMed 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
innate immune response IEA
Inferred from Electronic Annotation
more info
 
leukocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 
pattern recognition receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
phagocytosis, recognition IDA
Inferred from Direct Assay
more info
PubMed 
stimulatory C-type lectin receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane TAS
Traceable Author Statement
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
C-type lectin domain family 7 member A
Names
C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12
C-type lectin domain family 7, member A
C-type lectin superfamily member 12
DC-associated C-type lectin 1
beta-glucan receptor
dectin-1
dendritic cell-associated C-type lectin 1
dendritic cell-associated C-type lectin-1
lectin-like receptor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016291.1 RefSeqGene

    Range
    5001..18493
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_179

mRNA and Protein(s)

  1. NM_022570.4NP_072092.2  C-type lectin domain family 7 member A isoform b

    See identical proteins and their annotated locations for NP_072092.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform b) compared to isoform a. Variant 2 has been alternatively referred to as variant 1 and isoform b has been alternatively referred to as beta in the literature.
    Source sequence(s)
    AF400596, AY009090, AY359002, CR749536, DA193873
    Consensus CDS
    CCDS8613.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    Q68D78
    Related
    ENSP00000266456, OTTHUMP00000164964, ENST00000353231, OTTHUMT00000257702
    Conserved Domains (3) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cd03593
    Location:74197
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
    PHA03097
    Location:33195
    PHA03097; C-type lectin-like protein; Provisional
  2. NM_197947.2NP_922938.1  C-type lectin domain family 7 member A isoform a

    See identical proteins and their annotated locations for NP_922938.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variant 1 has been alternatively referred to as variant 2 and isoform a has been alternatively referred to as alpha in the literature.
    Source sequence(s)
    AF400595, AY009090, AY359002, CR749536, DA193873
    Consensus CDS
    CCDS41753.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    A0A024RAN9, Q68D78
    Related
    ENSP00000302569, OTTHUMP00000233746, ENST00000304084, OTTHUMT00000390772
    Conserved Domains (2) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cd03593
    Location:120243
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  3. NM_197948.2NP_922939.1  C-type lectin domain family 7 member A isoform c

    See identical proteins and their annotated locations for NP_922939.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform c) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF400597, AY009090, AY359002, CR749536, DA193873
    Consensus CDS
    CCDS41754.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    Q68D78
    Related
    ENSP00000431461, OTTHUMP00000233748, ENST00000533022, OTTHUMT00000390774
    Conserved Domains (2) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cl02432
    Location:120164
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  4. NM_197949.2NP_922940.1  C-type lectin domain family 7 member A isoform d

    See identical proteins and their annotated locations for NP_922940.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two alternate exons, which results in a frameshift and an early stop codon, compared to variant 1. The resulting protein (isoform d) is shorter and contains a distinct C-terminus, compared to isoform a. Isoform d has been alternatively referred to as 'c' in the literature.
    Source sequence(s)
    AA361063, AY009090, AY026771, AY359002, CR749536, DA193873
    Consensus CDS
    CCDS53744.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    Q68D78
    Related
    ENSP00000298523, OTTHUMP00000233745, ENST00000298523, OTTHUMT00000390771
    Conserved Domains (2) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cl02432
    Location:74118
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
  5. NM_197950.2NP_922941.1  C-type lectin domain family 7 member A isoform e

    See identical proteins and their annotated locations for NP_922941.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate in-frame exon compared to variant 1, resulting in a shorter protein (isoform e) compared to isoform a.
    Source sequence(s)
    AF400599, AY009090, AY359002, CR749536, DA193873
    Consensus CDS
    CCDS8614.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    Q68D78
    Related
    ENSP00000379743, OTTHUMP00000164966, ENST00000396484, OTTHUMT00000257705
    Conserved Domains (1) summary
    cd03593
    Location:41164
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  6. NM_197954.2NP_922945.1  C-type lectin domain family 7 member A isoform f

    See identical proteins and their annotated locations for NP_922945.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple differences in the coding region, compared to variant 1, one of which results in an early stop codon. The resulting protein (isoform f) has a distinct C-terminus and is much shorter than isoform a.
    Source sequence(s)
    BC013385, DA193873
    Consensus CDS
    CCDS8617.1
    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    A0A0S2Z5Q1
    Related
    ENSP00000312089, OTTHUMP00000164965, ENST00000310002, OTTHUMT00000257704
    Conserved Domains (1) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region

RNA

  1. NR_125336.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK294111, AY359002, DA193873

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    10116777..10130273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253467.3XP_005253524.1  

    See identical proteins and their annotated locations for XP_005253524.1

    UniProtKB/Swiss-Prot
    Q9BXN2
    UniProtKB/TrEMBL
    A0A024RAN9
    Related
    ENSP00000432876, OTTHUMP00000233744, ENST00000529761, OTTHUMT00000390770
    Conserved Domains (2) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cd03593
    Location:120243
    CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)
  2. XM_006719135.2XP_006719198.1  

    See identical proteins and their annotated locations for XP_006719198.1

    UniProtKB/Swiss-Prot
    Q9BXN2
    Related
    ENSP00000434392, OTTHUMP00000233749, ENST00000531192, OTTHUMT00000390775
    Conserved Domains (2) summary
    pfam08391
    Location:4067
    Ly49; Ly49-like protein, N-terminal region
    cl02432
    Location:120164
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    10238652..10252134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_197951.1: Suppressed sequence

    Description
    NM_197951.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_197952.1: Suppressed sequence

    Description
    NM_197952.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  3. NM_197953.1: Suppressed sequence

    Description
    NM_197953.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.