B3gat2 beta-1,3-glucuronyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: B3gat2provided by RGD
Official Full Name: beta-1,3-glucuronyltransferase 2provided by RGD
Primary source: RGD:620903
See related: Ensembl:ENSRNOG00000046852 AllianceGenome:RGD:620903
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity. Involved in carbohydrate biosynthetic process. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Human ortholog(s) of this gene implicated in Barrett's esophagus and schizophrenia. Orthologous to human B3GAT2 (beta-1,3-glucuronyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 42.6), Thymus (RPKM 6.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (33663482..33746466)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (26167174..26250153)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (29984077..30068649)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH138843 (e-PCR)
- UniSTS:220930

AI462175 (e-PCR)
- UniSTS:158779

AU048507 (e-PCR)
- UniSTS:144957

B3gat2 (e-PCR), detects polymorphism
- UniSTS:507999

AI179168 (e-PCR)
- UniSTS:250498

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in carbohydrate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in carbohydrate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in chondroitin sulfate proteoglycan biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2

Names: UDP-glucuronosyltransferase S; galactoside beta-1,3-glucuronyltransferase; glcAT-D; glcAT-S; glucuronosyltransferase S

NP_072131.1

EC 2.4.1.135

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022609.2 → NP_072131.1 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 2 precursor

See identical proteins and their annotated locations for NP_072131.1

Status: PROVISIONAL

Source sequence(s)

AB010441

UniProtKB/Swiss-Prot

Q9Z137

UniProtKB/TrEMBL

A6JJA7, M0R3R1

Related

ENSRNOP00000063982.2, ENSRNOT00000075592.2

Conserved Domains (1) summary

cd00218
Location:81 → 306

GlcAT-I; Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis