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TPSB2 tryptase beta 2 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 64499, updated on 12-May-2016
Official Symbol
TPSB2provided by HGNC
Official Full Name
tryptase beta 2 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:14120
See related
Ensembl:ENSG00000197253 HPRD:10277; MIM:191081; Vega:OTTHUMG00000155926
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TPS2; tryptaseB; tryptaseC
Summary
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. These genes are characterized by several distinct features. They have a highly conserved 3' UTR and contain tandem repeat sequences at the 5' flank and 3' UTR which are thought to play a role in regulation of the mRNA stability. These genes have an intron immediately upstream of the initiator Met codon, which separates the site of transcription initiation from protein coding sequence. This feature is characteristic of tryptases but is unusual in other genes. The alleles of this gene exhibit an unusual amount of sequence variation, such that the alleles were once thought to represent two separate genes, beta II and beta III. Beta tryptases appear to be the main isoenzymes expressed in mast cells, whereas in basophils, alpha-tryptases predominate. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Orthologs
Location:
16p13.3
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (1228336..1230184, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1278336..1280185, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel subunit alpha1 H Neighboring gene uncharacterized LOC105371043 Neighboring gene tryptase gamma 1 Neighboring gene tryptase alpha/beta 1 Neighboring gene tryptase delta 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC39869

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
serine-type peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tryptase beta-2
Names
mast cell tryptase beta II
mast cell tryptase beta III
testicular tissue protein Li 163
NP_077078.5

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032951.1 RefSeqGene

    Range
    5001..6849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_024164.5NP_077078.5  tryptase beta-2 preproprotein

    See identical proteins and their annotated locations for NP_077078.5

    Status: REVIEWED

    Source sequence(s)
    AF099143
    UniProtKB/Swiss-Prot
    P20231
    Related
    ENSP00000482743, OTTHUMP00000276429, ENST00000606293, OTTHUMT00000342363
    Conserved Domains (2) summary
    smart00020
    Location:31267
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:31268
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    1228336..1230184 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    1278009..1279872 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)