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    SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [ Homo sapiens ]

    Gene ID: 6449, updated on 11-May-2012
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    Summary

    Official Symbol
    SGTAprovided by HGNC
    Official Full Name
    small glutamine-rich tetratricopeptide repeat (TPR)-containing, alphaprovided by HGNC
    Primary source
    HGNC:10819
    See related
    Ensembl:ENSG00000104969; HPRD:04568; MIM:603419
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SGT; hSGT; alphaSGT
    Summary
    This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
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    Genomic context

    Location :
    19p13
    Sequence :
    Chromosome: 19; NC_000019.9 (2754712..2783354, complement)
    See SGTA in Epigenomics, MapViewer

    Chromosome 19 - NC_000019.9Genomic Context describing neighboring genes Neighboring gene DIRAS family, GTP-binding RAS-like 1 Neighboring gene solute carrier family 39 (zinc transporter), member 3 Neighboring gene thimet oligopeptidase 1 Neighboring gene zinc finger protein 554

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    5. Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling. Xu G, et al. Nat Biotechnol, 2010 Aug. PMID 20639865.

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The recombinant human small glutamine-rich tetratricopeptide-repeat protein SGT has been purified and crystallized and preliminary analysis of the tetratricopeptide-repeat (TPR) domain is reported.
      Title: Expression, purification and preliminary crystallographic analysis of recombinant human small glutamine-rich tetratricopeptide-repeat protein.
    2. The TPR domain of SGT can bind Vpu and reduce the amount of HIV-1 virus p24, which is the viral capsid, secreted from cells transfected with the HIV-1 proviral construct.
      Title: Structural and functional characterization of human SGT and its interaction with Vpu of the human immunodeficiency virus type 1.
    3. For SNP rs1640262, homozygotes for minor allele were protected against PCOS. Haplotype 1 (G-A-T) associated with increased risk of PCOS. In PCOS, haplotype 2 (A-G-C) associated with increased insulin resistance, resulting in increased insulin secretion.
      Title: Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome.
    4. SGTA acts as a rheostat of androgen receptor signaling in prostate cancer
      Title: Control of androgen receptor signaling in prostate cancer by the cochaperone small glutamine rich tetratricopeptide repeat containing protein alpha.
    5. Observational study of gene-disease association. (HuGE Navigator)
      Title: Family-based analysis of candidate genes for polycystic ovary syndrome.
    6. small glutamine-rich protein/viral protein U-binding protein (SGT/UBP) is a cochaperone that negatively regulates Hsp70.
      Title: Small glutamine-rich protein/viral protein U-binding protein is a novel cochaperone that affects heat shock protein 70 activity.
    7. the sub-cellular localization of SGT was closely associated with Hsp90beta and apoptosis
      Title: SGT, a Hsp90beta binding partner, is accumulated in the nucleus during cell apoptosis.
    8. SGT is a new pro-apoptotic factor
      Title: Overexpression of small glutamine-rich TPR-containing protein promotes apoptosis in 7721 cells.
    9. interaction with the ubiquitin-dependent endocytosis motif of the growth hormone receptor
      Title: Small glutamine-rich tetratricopeptide repeat-containing protein (SGT) interacts with the ubiquitin-dependent endocytosis (UbE) motif of the growth hormone receptor.
    10. CSP modulates G protein function by preferentially targeting the inactive GDP-bound form of G alpha(s) and promoting GDP/GTP exchange; the guanine nucleotide exchange activity of full-length CSP is regulated by Hsc70-SGT
      Title: Characterization of the G alpha(s) regulator cysteine string protein.
    Submit: New GeneRIF Correction See all (13)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag The enhancement of HIV-1 particle release and Capsid export resulting from the interaction of HIV-1 Vpu with HIV-1 Gag also involves the interaction of both Vpu and Gag with Vpu-binding protein (Ubp; Vpu interactive protein; VIP; SGT; NP_003012) PubMed
    Vpu vpu Small glutamine-rich tetratricopeptide repeat containing protein, also known as Vpu-binding protein (Ubp) or Vpu interactive protein (VIP), interacts with both HIV-1 Vpu and Gag to play a role in Vpu-mediated enhancement of HIV-1 virion release from cells PubMed

    Go to the HIV-1, Human Protein Interaction Database

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_003012.1 NP_005250.1 MSTN    BIND  PubMed hSGT interacts with the amino terminal region of myostatin. 
    O43765 P46379 BAG6    HPRD  PubMed  
    O43765 Q9BXJ1 C1QTNF1    HPRD  PubMed  
    O43765 Q12805 EFEMP1    HPRD  PubMed  
    O43765 O95967 EFEMP2    HPRD  PubMed  
    O43765 Q9Y624 F11R    HPRD  PubMed  
    O43765 P10912 GHR    HPRD  PubMed  
    O43765 Q96SL4 GPX7    HPRD  PubMed  
    O43765 O14793 MSTN    HPRD  PubMed  
    O43765 Q13232 NME3    HPRD  PubMed  
    O43765 P35080 PFN2    HPRD  PubMed  
    O43765 P21246 PTN    HPRD  PubMed  
    O43765 O43765 SGTA    HPRD  PubMed  
    O43765 P10451 SPP1    HPRD  PubMed  
    O43765 Q8TCT8 SPPL2A    HPRD  PubMed  
    O43765 P10124 SRGN    HPRD  PubMed  
    O43765 Q9H2B2 SYT4    HPRD  PubMed  
    O43765 P42166 TMPO    HPRD  PubMed  
    O43765 O60844 ZG16    HPRD  PubMed  
    O43765 Immunoglobulin lambda constant 1     HPRD  PubMed  
    BioGRID:112347 BioGRID:125388 C1QTNF1    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:108496 EFEMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:119026 EFEMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:119153 F11R    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:108957 GHR    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112347 BioGRID:109139 GPX7    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:109552 HSP90AA1    BioGRID  PubMed Far Western 
    BioGRID:112347 BioGRID:109540 HSPA4    BioGRID  PubMed Far Western 
    BioGRID:112347 BioGRID:109753 IGLC1    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:110896 NME3    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:111238 PFN2    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:111500 PPP1R3C    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:111731 PTN    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:124834 RNF185    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112347 BioGRID:116152 SEC61B    BioGRID  PubMed Co-fractionation 
    BioGRID:112347 BioGRID:118079 SERP1    BioGRID  PubMed Co-fractionation 
    BioGRID:112347 BioGRID:112574 SPP1    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:124328 SPPL2A    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:111543 SRGN    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:112724 SYT4    BioGRID  PubMed Two-hybrid 
    BioGRID:112347 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112347 BioGRID:113885 UBL4A    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		  
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    small glutamine-rich tetratricopeptide repeat-containing protein alpha
    Names
    small glutamine-rich tetratricopeptide repeat-containing protein alpha
    UBP
    alpha-SGT
    vpu-binding protein
    protein containing three tetratricopeptide repeats
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003021.3 → NP_003012.1  small glutamine-rich tetratricopeptide repeat-containing protein alpha

      Status: REVIEWED

      Source sequence(s)
      AL050156, BC005165, BG423904
      Consensus CDS
      CCDS12094.1
      UniProtKB/Swiss-Prot
      O43765
      Related
      ENSP00000221566, ENST00000221566
      Conserved Domains (2) summary
      cd00189
      Location:92 – 191
      Blast Score: 223
      TPR; Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]-X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi, ...
      pfam13414
      Location:90 – 156
      Blast Score: 159
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000019.9 Reference GRCh37.p5 Primary Assembly

      Range
      2754712..2783354, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000151.1 Alternate HuRef

      Range
      2524858..2552844, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC006538.1 AAD13117.1
    genomic CH471139.2 EAW69366.1
      EAW69367.1
      EAW69368.1
    mRNA AF368279.1 AAP29457.1
    mRNA AF408399.1 AAL01051.1
    mRNA AJ133129.1 CAB39725.1
    mRNA AJ223828.1 CAA11565.1
    mRNA AK293535.1 BAG57017.1
    mRNA AL050156.1 CAB43297.2
    mRNA BC000390.2 AAH00390.1
    mRNA BC002989.1 AAH02989.2
    mRNA BC005165.2 AAH05165.1
    mRNA BC008885.2 AAH08885.1
    mRNA BG423904.1 None
    mRNA CR533517.1 CAG38548.1
    mRNA CR542282.1 CAG47077.1
    other-genetic AM393459.1 CAL38336.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43765.1 GenPept UniProtKB/Swiss-Prot:O43765
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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