SGK1 serum/glucocorticoid regulated kinase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: SGK1provided by HGNC
Official Full Name: serum/glucocorticoid regulated kinase 1provided by HGNC
Primary source: HGNC:10810
Locus tag: RP1-188K17.1
See related: Ensembl:ENSG00000118515; HPRD:04264; MIM:602958; Vega:OTTHUMG00000015613
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGK
Summary: This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

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Genomic context

Location :: 6q23

Sequence :: Chromosome: 6; NC_000006.11 (134490384..134639196, complement)

See SGK1 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data show that SGK1 regulates cell migration via vinculin dephosphorylation, a mechanism that is controlled by membrane androgen receptor function.
Title: Serum- and glucocorticoid-dependent kinase-1-induced cell migration is dependent on vinculin and regulated by the membrane androgen receptor.
SGK1 expression is high in most untreated prostate cancers and declines with androgen deprivation. However, these data suggest that relatively low expression of SGK1 is associated with higher tumor grade and increased cancer recurrence.
Title: Serum/glucocorticoid-regulated kinase 1 expression in primary human prostate cancers.
Data show that deregulated SGK1 activity in cycling endometrium interferes with embryo implantation, leading to infertility, or predisposes to pregnancy complications by rendering the feto-maternal interface vulnerable to oxidative damage.
Title: Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure.
Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.
Title: Neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2) regulation by 14-3-3 protein binding at canonical serum and glucocorticoid kinase 1 (SGK1) phosphorylation sites.
SGK1 expression is enhanced in the temporal neocortex of patients with drug-refractory epilepsy.
Title: Up-regulation of serum- and glucocorticoid-induced protein kinase 1 in the brain tissue of human and experimental epilepsy.
the association of sgk1 with the apical cell membrane, where it interacts with ENaC, is a novel means by which sgk1 specifically enhances ENaC activity in aldosterone-stimulated collecting duct cells.
Title: Epithelial sodium channel regulation by cell surface-associated serum- and glucocorticoid-regulated kinase 1.
mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel
Title: mSIN1 protein mediates SGK1 protein interaction with mTORC2 protein complex and is required for selective activation of the epithelial sodium channel.
results suggest that testosterone up-regulates SGK-1 in the kidney contributing to sexual dimorphisms in the cell signalling machinery
Title: Gender differences in serum and glucocorticoid regulated kinase-1 (SGK-1) expression during renal ischemia/reperfusion injury.
SGK1 is a highly cytokine-responsive gene in myeloma cells promoting their malignant growth
Title: Serum/glucocorticoid-regulated kinase 1 (SGK1) is a prominent target gene of the transcriptional response to cytokines in multiple myeloma and supports the growth of myeloma cells.
in 2 populations, observed an association between genetic variants in SGK1 and ischaemic stroke; this could imply that cerebrovascular amiloride-sensitive sodium channel or other SGK1-regulated proteins may be important for development of ischaemic stroke
Title: Genetic variants in serum and glucocortocoid regulated kinase 1, a regulator of the epithelial sodium channel, are associated with ischaemic stroke.

Submit: New GeneRIF Correction See all (102)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NC_000006.9	NP_001895.1	CTNNB1	BIND	PubMed	CTNNB1 (beta-catenin) interacts with the SGK promoter.
O00141	P15056	BRAF	HPRD	PubMed
O00141	Q8N5S9	CAMKK1	HPRD	PubMed
O00141	P16220	CREB1	HPRD	PubMed
O00141	O43524	FOXO3	HPRD	PubMed
O00141	P49840	GSK3A	HPRD	PubMed
O00141	P49841	GSK3B	HPRD	PubMed
O00141	P48048	KCNJ1	HPRD	PubMed
O00141	P52292	KPNA2	HPRD	PubMed
O00141	Q13164	MAPK7	HPRD	PubMed
O00141	P46934	NEDD4	HPRD	PubMed
O00141	Q96PU5	NEDD4L	HPRD	PubMed
O00141	Q9HC98	NEK6	HPRD	PubMed
O00141	Q15119	PDK2	HPRD	PubMed
O00141	O15530	PDPK1	HPRD	PubMed
O00141	P43003	SLC1A3	HPRD	PubMed
O00141	Q15599	SLC9A3R2	HPRD	PubMed
BioGRID:112344	BioGRID:115889	CAMKK2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:117124	CARHSP1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112344	BioGRID:107396	CD40	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:116312	CDC37	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:127317	COMMD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:114032	CUL1	BioGRID	PubMed	Biochemical Activity
BioGRID:112344	BioGRID:108472	FANCA	BioGRID	PubMed	Two-hybrid
BioGRID:112344	BioGRID:109605	IARS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:109714	IGHA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:114089	IKBKG	BioGRID	PubMed	Reconstituted Complex
BioGRID:112344	BioGRID:110036	KPNA2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:112344	BioGRID:110235	LTF	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:111584	MAPK7	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex; Two-hybrid
BioGRID:112344	BioGRID:110446	MLLT3	BioGRID	PubMed	Biochemical Activity
BioGRID:112344	BioGRID:110811	NEDD4	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex
BioGRID:112344	BioGRID:111075	PA2G4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:111189	PDK1	BioGRID	PubMed	Biochemical Activity
BioGRID:112344	BioGRID:111196	PDPK1	BioGRID	PubMed	Reconstituted Complex
BioGRID:112344	BioGRID:111302	PIGR	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:111308	PIK3CA	BioGRID	PubMed	Reconstituted Complex
BioGRID:112344	BioGRID:111507	PPP2CA	BioGRID	PubMed	Reconstituted Complex
BioGRID:112344	BioGRID:111831	RAF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:128962	RICTOR	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:112344	BioGRID:112242	SCNN1B	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:114754	SLC9A3R2	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:112344	BioGRID:115563	STUB1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:124085	SYVN1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:108165	TSC22D3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:113135	TUFM	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112344	BioGRID:113258	VCP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:112344	BioGRID:34010	YPK1	BioGRID	PubMed	Dosage Rescue

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
calcium channel regulator activity	TAS Traceable Author Statement more info
chloride channel regulator activity	TAS Traceable Author Statement more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
potassium channel regulator activity	TAS Traceable Author Statement more info
protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
sodium channel regulator activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
long-term memory	TAS Traceable Author Statement more info
positive regulation of transporter activity	TAS Traceable Author Statement more info
protein phosphorylation	TAS Traceable Author Statement more info	PubMed
regulation of apoptotic process	TAS Traceable Author Statement more info
regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
regulation of catalytic activity	TAS Traceable Author Statement more info
regulation of cell growth	TAS Traceable Author Statement more info
regulation of cell migration	TAS Traceable Author Statement more info
regulation of cell proliferation	TAS Traceable Author Statement more info
regulation of gastric acid secretion	TAS Traceable Author Statement more info
regulation of sequence-specific DNA binding transcription factor activity	TAS Traceable Author Statement more info
renal sodium ion absorption	TAS Traceable Author Statement more info	PubMed
response to stress	IEA Inferred from Electronic Annotation more info
sodium ion transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: serine/threonine-protein kinase Sgk1

Names: serine/threonine-protein kinase Sgk1; Sgk1 variant i3; serine/threonine protein kinase SGK; serum/glucocorticoid-regulated kinase 1

NP_001137148.1

EC 2.7.11.1

NP_001137149.1

EC 2.7.11.1

NP_001137150.1

EC 2.7.11.1

NP_005618.2

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143676.1 → NP_001137148.1 serine/threonine-protein kinase Sgk1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains additional in-frame exons at the 5' end compared to transcript variant 1, resulting in an isoform (2) with a longer and an unique N-terminus compared to isoform 1. Isoform 2 is reported to have an increased protein half-life, and is preferentially targeted to the plasma membrane.

Source sequence(s)

AK055077, BP384292, EU518415

Consensus CDS

CCDS47476.1

UniProtKB/Swiss-Prot

O00141

Related

ENSP00000356832, OTTHUMP00000017246, ENST00000367858, OTTHUMT00000042304

Conserved Domains (3) summary

cd05602
Location:197 – 521
Blast Score: 1645

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

smart00220
Location:193 – 450
Blast Score: 749

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02563
Location:109 – 153
Blast Score: 117

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_001143677.1 → NP_001137149.1 serine/threonine-protein kinase Sgk1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (3) with a longer and an unique N-terminus compared to isoform 1.

Source sequence(s)

AK098509, BP384292, DA309338

Consensus CDS

CCDS47477.1

UniProtKB/Swiss-Prot

O00141

Related

ENSP00000434450, OTTHUMP00000234028, ENST00000528577, OTTHUMT00000391146

Conserved Domains (3) summary

cd05575
Location:130 – 452
Blast Score: 1636

STKc_SGK; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase

smart00220
Location:126 – 383
Blast Score: 746

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02563
Location:55 – 86
Blast Score: 92

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_001143678.1 → NP_001137150.1 serine/threonine-protein kinase Sgk1 isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (4) contains an alternative in-frame, 5' terminal exon compared to transcript variant 1, resulting in an isoform (4) with a longer and an unique N-terminus compared to isoform 1.

Source sequence(s)

AK098509, BP384292, DC428953

Consensus CDS

CCDS47478.1

UniProtKB/Swiss-Prot

O00141

Related

ENSP00000396242, OTTHUMP00000017248, ENST00000413996, OTTHUMT00000042313

Conserved Domains (3) summary

cd05602
Location:116 – 440
Blast Score: 1639

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

smart00220
Location:112 – 369
Blast Score: 741

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02563
Location:41 – 72
Blast Score: 92

PX_domain; The Phox Homology domain, a phosphoinositide binding module
NM_005627.3 → NP_005618.2 serine/threonine-protein kinase Sgk1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the shortest isoform (1).

Source sequence(s)

AK098509, BP384292, DB450096

Consensus CDS

CCDS5170.1

UniProtKB/Swiss-Prot

O00141

Related

ENSP00000237305, OTTHUMP00000017247, ENST00000237305, OTTHUMT00000042312

Conserved Domains (3) summary

cd05602
Location:102 – 426
Blast Score: 1645

STKc_SGK1; Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1

smart00220
Location:98 – 355
Blast Score: 741

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl02563
Location:27 – 58
Blast Score: 92

PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

134490384..134639196, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

132059144..132203585, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AF460178.1	AAN40971.1
genomic	AJ000512.1	CAA04146.1
genomic	AL135839.15	CAI19718.1
		CAI19719.1
		CAI19720.1
		CAI19721.1
genomic	AL135839.15	CAI19718.1
		CAI19719.1
		CAI19720.1
		CAI19721.1
genomic	AL355881.15	CAH72579.1
genomic	CH471051.2	EAW47991.1
		EAW47992.1
		EAW47993.1
genomic	Z84486.1	CAI21678.1
mRNA	AF153609.1	AAD41091.1
mRNA	AK055077.1	BAG51463.1
mRNA	AK098509.1	None
mRNA	AK293383.1	BAH11497.1
mRNA	AK295422.1	BAH12061.1
mRNA	AK298688.1	BAH12848.1
mRNA	BC001263.1	AAH01263.1
mRNA	BC013832.1	None
mRNA	BP384292.1	None
mRNA	BQ183142.1	None
mRNA	BX649005.1	CAH10381.1
mRNA	DA309338.1	None
mRNA	DB450096.1	None
mRNA	DC428953.1	None
mRNA	EU518415.1	ACD35864.1
mRNA	FM205707.1	CAR58095.1
mRNA	FM205708.1	CAR58096.1
mRNA	FM205709.1	CAR58097.1
mRNA	FM205710.1	CAR58098.1
mRNA	JQ836654.1	AFJ04414.1
mRNA	Y10032.1	CAA71138.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O00141.2	GenPept	UniProtKB/Swiss-Prot:O00141
Q6AW81	GenPept	UniProtKB/TrEMBL:Q6AW81
Q8IZV4	GenPept	UniProtKB/TrEMBL:Q8IZV4