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IKZF5 IKAROS family zinc finger 5 [ Homo sapiens (human) ]

Gene ID: 64376, updated on 26-May-2016
Official Symbol
IKZF5provided by HGNC
Official Full Name
IKAROS family zinc finger 5provided by HGNC
Primary source
HGNC:HGNC:14283
See related
Ensembl:ENSG00000095574 HPRD:05873; MIM:606238; Vega:OTTHUMG00000019192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEGASUS; ZNFN1A5
Summary
Members of the Ikaros (ZNFN1A1; MIM 603023) family of transcription factors, which includes Pegasus, are expressed in lymphocytes and are implicated in the control of lymphoid development.[supplied by OMIM, Jul 2002]
Orthologs
Location:
10q26
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 10 NC_000010.11 (122990806..123008850, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (124750322..124768366, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 24 member A Neighboring gene chromosome 10 open reading frame 88 Neighboring gene phosphoseryl-tRNA kinase Neighboring gene acyl-CoA dehydrogenase, short/branched chain Neighboring gene H6 family homeobox 3

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13226, FLJ22973, FLJ30945, DKFZp781B0249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
zinc finger protein Pegasus
Names
IKAROS family zinc finger 5 (Pegasus)
zinc finger protein, subfamily 1A, 5 (Pegasus)
zinc finger transcription factor Pegasus

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271840.1NP_001258769.1  zinc finger protein Pegasus

    See identical proteins and their annotated locations for NP_001258769.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the functional protein.
    Source sequence(s)
    AC073585, AI560579, DA218215
    Consensus CDS
    CCDS41574.1
    UniProtKB/Swiss-Prot
    Q9H5V7
    Related
    ENSP00000478056, ENST00000617859
    Conserved Domains (3) summary
    pfam10253
    Location:297362
    PRCC; Mitotic checkpoint regulator, MAD2B-interacting
    pfam13465
    Location:124148
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_073475.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073585, AI560579, AK026626
  2. NR_073476.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073585, AI560579, AK226143
  3. NR_073477.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' exon and uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073585, AI560579, AK026626, DB080324
  4. NR_073478.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073585, AI560579, AK026626, DA227834
  5. NR_073479.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC073585, AI560579, AK026626, DB224006

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p2 Primary Assembly

    Range
    122990806..123008850 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717947.2XP_006718010.1  

    See identical proteins and their annotated locations for XP_006718010.1

    UniProtKB/Swiss-Prot
    Q9H5V7
    Related
    ENSP00000357881, OTTHUMP00000020670, ENST00000368886, OTTHUMT00000050820
    Conserved Domains (3) summary
    pfam10253
    Location:297362
    PRCC; Mitotic checkpoint regulator, MAD2B-interacting
    pfam13465
    Location:124148
    zf-H2C2_2; Zinc-finger double domain
    sd00017
    Location:84104
    ZF_C2H2; C2H2 Zn finger [structural motif]

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 Alternate CHM1_1.1

    Range
    125032052..125050096 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)