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NXN nucleoredoxin [ Homo sapiens (human) ]

Gene ID: 64359, updated on 26-May-2016
Official Symbol
NXNprovided by HGNC
Official Full Name
nucleoredoxinprovided by HGNC
Primary source
HGNC:HGNC:18008
See related
Ensembl:ENSG00000167693 HPRD:14858; MIM:612895; Vega:OTTHUMG00000090307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NRX; TRG-4
Summary
This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Orthologs
Location:
17p13.3
Exon count:
11
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (799313..979767, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (702553..883017, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 4 Neighboring gene diazepam binding inhibitor-like 5, pseudogene Neighboring gene glyoxalase domain containing 4 Neighboring gene mitochondrial rRNA methyltransferase 3 Neighboring gene uncharacterized LOC101927727 Neighboring gene uncharacterized LOC100130876 Neighboring gene uncharacterized LOC105371482 Neighboring gene translocase of inner mitochondrial membrane 22 homolog (yeast) Neighboring gene active BCR-related

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
NHGRI GWA Catalog
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
NHGRI GWA Catalog
The genetic architecture of economic and political preferences.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ12614

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
thioredoxin-disulfide reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cardiovascular system development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
negative regulation of Wnt signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein ubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
nucleoredoxin
Names
nucleoredoxin 1
NP_001192248.1
NP_071908.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205319.1NP_001192248.1  nucleoredoxin isoform 2

    See identical proteins and their annotated locations for NP_001192248.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC087392, BC009327
    Consensus CDS
    CCDS56013.1
    UniProtKB/Swiss-Prot
    Q6DKJ4
    Related
    ENSP00000461038, OTTHUMP00000256803, ENST00000575801, OTTHUMT00000437224
    Conserved Domains (3) summary
    cd03009
    Location:68199
    TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...
    cd03071
    Location:204319
    PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...
    cl00388
    Location:857
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_022463.4NP_071908.2  nucleoredoxin isoform 1

    See identical proteins and their annotated locations for NP_071908.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087392, AW752727, BC063828, CX786695
    Consensus CDS
    CCDS10998.1
    UniProtKB/Swiss-Prot
    Q6DKJ4
    Related
    ENSP00000337443, OTTHUMP00000115356, ENST00000336868, OTTHUMT00000206669
    Conserved Domains (3) summary
    cd03009
    Location:176307
    TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...
    cd03071
    Location:312427
    PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...
    cl00388
    Location:11165
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    799313..979767 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256756.3XP_005256813.1  

    Conserved Domains (1) summary
    cl00388
    Location:274367
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. XM_005256758.2XP_005256815.1  

    Conserved Domains (3) summary
    cd03009
    Location:63194
    TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...
    cd03071
    Location:199314
    PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...
    cl00388
    Location:352
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. XM_005256757.2XP_005256814.1  

    See identical proteins and their annotated locations for XP_005256814.1

    Conserved Domains (3) summary
    cd03009
    Location:68199
    TryX_like_TryX_NRX; Tryparedoxin (TryX)-like family, TryX and nucleoredoxin (NRX) subfamily; TryX and NRX are thioredoxin (TRX)-like protein disulfide oxidoreductases that alter the redox state of target proteins via the reversible oxidation of an active center CXXC motif. ...
    cd03071
    Location:204319
    PDI_b'_NRX; PDIb' family, NRX subgroup, redox inactive TRX-like domain b'; composed of vertebrate nucleoredoxins (NRX). NRX is a 400-amino acid nuclear protein with one redox active TRX domain followed by one redox inactive TRX-like domain homologous to the b' ...
    cl00388
    Location:757
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

Reference GRCh38.p2 ALT_REF_LOCI_1

Genomic

  1. NT_187613.1 Reference GRCh38.p2 ALT_REF_LOCI_1

    Range
    3030..19005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p2 ALT_REF_LOCI_2

Genomic

  1. NT_187664.1 Reference GRCh38.p2 ALT_REF_LOCI_2

    Range
    3030..19005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    711357..891770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)