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XPO4 exportin 4 [ Homo sapiens (human) ]

Gene ID: 64328, updated on 13-Jan-2015
Official Symbol
XPO4provided by HGNC
Official Full Name
exportin 4provided by HGNC
Primary source
HGNC:HGNC:17796
See related
Ensembl:ENSG00000132953; HPRD:18307; MIM:611449; Vega:OTTHUMG00000016528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
exp4
Summary
XPO4 belongs to a large family of karyopherins (see MIM 602738) that mediate the transport of proteins and other cargo between the nuclear and cytoplasmic compartments (Lipowsky et al., 2000 [PubMed 10944119]).[supplied by OMIM, Mar 2009]
Orthologs
See XPO4 in MapViewer
Location:
13q11
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 13 NC_000013.11 (20777329..20902774, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (21351468..21476913, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507583 Neighboring gene interleukin 17D Neighboring gene N-6 adenine-specific DNA methyltransferase 2 (putative) Neighboring gene RAN, member RAS oncogene family pseudogene 8 Neighboring gene CCR4-NOT transcription complex, subunit 4 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 367 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 30

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with exportin 4 (XPO4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ13046, KIAA1721

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
positive regulation of protein export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
Preferred Names
exportin-4
Names
exportin-4

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022459.4NP_071904.4  exportin-4

    See proteins identical to NP_071904.4

    Status: VALIDATED

    Source sequence(s)
    AB051508, AL512652, BQ184183, DA119417
    Consensus CDS
    CCDS41872.1
    UniProtKB/Swiss-Prot
    Q9C0E2
    Related
    ENSP00000255305, OTTHUMP00000018105, ENST00000255305, OTTHUMT00000044096

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000013.11 

    Range
    20777329..20902774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005266503.2XP_005266560.1  

    See proteins identical to XP_005266560.1

  2. XM_005266502.1XP_005266559.1  

    See proteins identical to XP_005266559.1

  3. XM_005266504.1XP_005266561.1  

Alternate CHM1_1.1

Genomic

  1. NC_018924.2 

    Range
    21319619..21445055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000145.1 

    Range
    2154552..2279991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)