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Casp2 caspase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 64314, updated on 26-May-2016
Official Symbol
Casp2provided by RGD
Official Full Name
caspase 2provided by RGD
Primary source
RGD:69274
See related
Ensembl:ENSRNOG00000016707
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
may play a role in proteolysis and programmed cell death [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
4q23
Exon count:
12
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (71652362..71670228)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 4 NC_005103.3 (136454723..136474625)

Chromosome 4 - NC_005103.4Genomic Context describing neighboring genes Neighboring gene peroxiredoxin-1-like Neighboring gene transmembrane protein 139 Neighboring gene chloride voltage-gated channel 1 Neighboring gene family with sequence similarity 131, member B Neighboring gene zyxin Neighboring gene Eph receptor A1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
molecular_function ND
No biological Data available
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest ISO
Inferred from Sequence Orthology
more info
 
aging IEP
Inferred from Expression Pattern
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
brain development IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus ISO
Inferred from Sequence Orthology
more info
 
ectopic germ cell programmed cell death IEA
Inferred from Electronic Annotation
more info
 
ectopic germ cell programmed cell death ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
luteolysis IEP
Inferred from Expression Pattern
more info
PubMed 
neural retina development IEP
Inferred from Expression Pattern
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
programmed cell death TAS
Traceable Author Statement
more info
PubMed 
protein processing IEA
Inferred from Electronic Annotation
more info
 
protein processing ISO
Inferred from Sequence Orthology
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
proteolysis TAS
Traceable Author Statement
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
caspase-2
Names
CASP-2
ICH-1 protease
protease ICH-1
NP_071967.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022522.2NP_071967.2  caspase-2

    See identical proteins and their annotated locations for NP_071967.2

    Status: PROVISIONAL

    Source sequence(s)
    U77933
    UniProtKB/Swiss-Prot
    P55215
    Related
    ENSRNOP00000022672, ENSRNOT00000022672
    Conserved Domains (2) summary
    cd00032
    Location:191446
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:32118
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005103.4 Reference Rnor_6.0 Primary Assembly

    Range
    71652362..71670228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006236394.2XP_006236456.1  

    Conserved Domains (2) summary
    cd00032
    Location:200455
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cd08332
    Location:41127
    CARD_CASP2; Caspase activation and recruitment domain of Caspase-2
  2. XM_008762918.1XP_008761140.1  

    Conserved Domains (2) summary
    cl00042
    Location:201336
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
    cl14633
    Location:41127
    DD; Death Domain Superfamily of protein-protein interaction domains

RNA

  1. XR_592090.1 RNA Sequence

    Related
    ENSRNOT00000022543

Alternate Rn_Celera

Genomic

  1. AC_000072.1 Alternate Rn_Celera

    Range
    66080364..66098003
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)