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ATL2 atlastin GTPase 2 [ Homo sapiens (human) ]

Gene ID: 64225, updated on 12-May-2016
Official Symbol
ATL2provided by HGNC
Official Full Name
atlastin GTPase 2provided by HGNC
Primary source
HGNC:HGNC:24047
See related
Ensembl:ENSG00000119787 HPRD:10662; MIM:609368; Vega:OTTHUMG00000102074
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARL3IP2; ARL6IP2; atlastin2
Orthologs
Location:
2p22.3
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (38294094..38378139, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (38522027..38604432, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374467 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 25 Neighboring gene uncharacterized LOC105374468 Neighboring gene uncharacterized LOC100996902

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ23293

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
Golgi organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
atlastin-2
Names
ADP-ribosylation factor-like 6 interacting protein 2
ADP-ribosylation factor-like protein 6-interacting protein 2
ADP-ribosylation-like factor 6 interacting protein 2
ARL-6-interacting protein 2
aip-2
NP_001129145.1
NP_071769.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135673.2NP_001129145.1  atlastin-2 isoform 2

    See identical proteins and their annotated locations for NP_001129145.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice acceptor site in the 3' terminal exon, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC016995, AI630457, AK225190, BC039050, DA643528
    Consensus CDS
    CCDS46260.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000368237, OTTHUMP00000128258, ENST00000378954, OTTHUMT00000219886
    Conserved Domains (1) summary
    cd01851
    Location:90334
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  2. NM_001308076.1NP_001295005.1  atlastin-2 isoform 3

    See identical proteins and their annotated locations for NP_001295005.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' terminal exon, resulting in translation initiation at an alternate start codon, and uses an alternate splice acceptor site in the 3' terminal exon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AC016995, AI630457, AK302621, BC039050, BX507348
    Consensus CDS
    CCDS77402.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Conserved Domains (1) summary
    cd01851
    Location:72316
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  3. NM_022374.3NP_071769.2  atlastin-2 isoform 1

    See identical proteins and their annotated locations for NP_071769.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform (1).
    Source sequence(s)
    AC016995, AI630457, AK026946, AK124434, BC039050, DA643528
    Consensus CDS
    CCDS1795.1
    UniProtKB/Swiss-Prot
    Q8NHH9
    Related
    ENSP00000415336, OTTHUMP00000128257, ENST00000419554, OTTHUMT00000219885
    Conserved Domains (1) summary
    cd01851
    Location:90334
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)

RNA

  1. NR_024191.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) omits an exon compared to variant 1 resulting in a transcript that is a candidate for nonsense-mediated decay which is unlikely to encode a protein.
    Source sequence(s)
    AK308894, BC039050, BC053508, DA643528

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    38294094..38378139 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533018.1XP_011531320.1  

    Conserved Domains (1) summary
    cd01851
    Location:85329
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  2. XM_011533017.1XP_011531319.1  

    Conserved Domains (1) summary
    cd01851
    Location:90334
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  3. XM_011533022.1XP_011531324.1  

    UniProtKB/TrEMBL
    B5MCN0
    Related
    ENSP00000385446, OTTHUMP00000201420, ENST00000406122, OTTHUMT00000325703
    Conserved Domains (1) summary
    cd01851
    Location:1163
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  4. XM_011533021.1XP_011531323.1  

    See identical proteins and their annotated locations for XP_011531323.1

    Conserved Domains (1) summary
    cd01851
    Location:36280
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  5. XM_006712071.2XP_006712134.1  

    Related
    ENSP00000390743, OTTHUMP00000201418, ENST00000452935, OTTHUMT00000325694
    Conserved Domains (1) summary
    cd01851
    Location:72316
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  6. XM_011533019.1XP_011531321.1  

    See identical proteins and their annotated locations for XP_011531321.1

    UniProtKB/Swiss-Prot
    Q8NHH9
    Conserved Domains (1) summary
    cd01851
    Location:72316
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  7. XM_006712072.2XP_006712135.2  

    Conserved Domains (1) summary
    cd01851
    Location:109353
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  8. XM_011533020.1XP_011531322.1  

    See identical proteins and their annotated locations for XP_011531322.1

    Conserved Domains (1) summary
    cd01851
    Location:36280
    GBP; Guanylate-binding protein (GBP) family (N-terminal domain)
  9. XM_011533023.1XP_011531325.1  

    Conserved Domains (1) summary
    cl22891
    Location:1114
    GBP; Guanylate-binding protein, N-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    38451392..38534265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)