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POPDC3 popeye domain containing 3 [ Homo sapiens (human) ]

Gene ID: 64208, updated on 12-May-2016
Official Symbol
POPDC3provided by HGNC
Official Full Name
popeye domain containing 3provided by HGNC
Primary source
HGNC:HGNC:17649
See related
Ensembl:ENSG00000132429 HPRD:16161; MIM:605824; Vega:OTTHUMG00000015293
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POP3; bA355M14.1
Summary
This gene encodes a member of the POP family of proteins containing three putative transmembrane domains. This gene is expressed in cardiac and skeletal muscle and may play an important role in these tissues during development. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2008]
Orthologs
Location:
6q21
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (105157900..105180009, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (105605775..105627858, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LIN28B antisense RNA 1 Neighboring gene lin-28 homolog B Neighboring gene blood vessel epicardial substance Neighboring gene BVES antisense RNA 1 Neighboring gene uncharacterized LOC105377920 Neighboring gene ribosomal protein L7a pseudogene 35 Neighboring gene prolyl endopeptidase

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche.
NHGRI GWA Catalog
Genome-wide association study of severity in multiple sclerosis.
NHGRI GWA Catalog
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Markers

Homology

Clone Names

  • MGC22671

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
regulation of membrane potential ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
popeye domain-containing protein 3
Names
popeye protein 3

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022361.4NP_071756.2  popeye domain-containing protein 3

    See identical proteins and their annotated locations for NP_071756.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes a protein of 291 aa.
    Source sequence(s)
    AK314101, AL356775, AL359709
    Consensus CDS
    CCDS5052.1
    UniProtKB/Swiss-Prot
    Q9HBV1
    Related
    ENSP00000254765, OTTHUMP00000016914, ENST00000254765, OTTHUMT00000041651
    Conserved Domains (1) summary
    pfam04831
    Location:107258
    Popeye; Popeye protein conserved region

RNA

  1. NR_024539.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment, as compared to variant 1. It is a nonsense-mediated mRNA decay (NMD) candidate and does not make a functional protein.
    Source sequence(s)
    AK225989, AL356775

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    105157900..105180009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536069.1XP_011534371.1  

    See identical proteins and their annotated locations for XP_011534371.1

    UniProtKB/Swiss-Prot
    Q9HBV1
    Conserved Domains (1) summary
    pfam04831
    Location:107258
    Popeye; Popeye protein conserved region
  2. XM_011536068.1XP_011534370.1  

    See identical proteins and their annotated locations for XP_011534370.1

    UniProtKB/Swiss-Prot
    Q9HBV1
    Conserved Domains (1) summary
    pfam04831
    Location:107258
    Popeye; Popeye protein conserved region
  3. XM_011536067.1XP_011534369.1  

    See identical proteins and their annotated locations for XP_011534369.1

    UniProtKB/Swiss-Prot
    Q9HBV1
    Conserved Domains (1) summary
    pfam04831
    Location:107258
    Popeye; Popeye protein conserved region
  4. XM_011536070.1XP_011534372.1  

    See identical proteins and their annotated locations for XP_011534372.1

    UniProtKB/Swiss-Prot
    Q9HBV1
    Conserved Domains (1) summary
    pfam04831
    Location:107258
    Popeye; Popeye protein conserved region

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    105867475..105889561 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)