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DPEP2 dipeptidase 2 [ Homo sapiens (human) ]

Gene ID: 64174, updated on 8-May-2016
Official Symbol
DPEP2provided by HGNC
Official Full Name
dipeptidase 2provided by HGNC
Primary source
HGNC:HGNC:23028
See related
Ensembl:ENSG00000167261 HPRD:07011; MIM:609925; Vega:OTTHUMG00000137542
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MBD2
Summary
DPEP2 belongs to the membrane-bound dipeptidase (EC 3.4.13.19) family. These enzymes hydrolyze a variety of dipeptides, including leukotriene D4, the beta-lactam ring of some antibiotics, and cystinyl-bis-glycine (cys-bis-gly) formed during glutathione degradation (Habib et al., 2003 [PubMed 12738806]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
16q22.1
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 16 NC_000016.10 (67987390..68000611, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (68021293..68034493, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene lecithin-cholesterol acyltransferase Neighboring gene solute carrier family 12 member 4 Neighboring gene dipeptidase 3 Neighboring gene lysyl-tRNA synthetase pseudogene 3 Neighboring gene uncharacterized LOC100131303

NHGRI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
NHGRI GWA Catalog
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
NHGRI GWA Catalog
  • Aflatoxin activation and detoxification, organism-specific biosystem (from REACTOME)
    Aflatoxin activation and detoxification, organism-specific biosystemAflatoxins are among the principal mycotoxins produced as secondary metabolites by the molds Aspergillus flavus and Aspergillus parasiticus that contaminate economically important food and feed crops...
  • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
    Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
    Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
  • leukotriene biosynthesis, organism-specific biosystem (from BIOCYC)
    leukotriene biosynthesis, organism-specific biosystemLeukotrienes are made by cells of the immune system, mainly the mediators of inflammation like polymorphonuclear leukocytes, macrophages and mast cells. Cellular activation during inflammation leads ...
  • leukotriene biosynthesis, conserved biosystem (from BIOCYC)
    leukotriene biosynthesis, conserved biosystemLeukotrienes are proinflammatory metabolites of arachidonic acid that activate and amplify innate and adaptive immune responses. They also have roles in pathologic immune responses, mediating contrac...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 
dipeptidyl-peptidase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloexopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324159.1NP_001311088.1  dipeptidase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC040162, KC877614
  2. NM_022355.3NP_071750.1  dipeptidase 2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_071750.1

    Status: VALIDATED

    Source sequence(s)
    AJ295149, BP299049, CB528462
    Consensus CDS
    CCDS10857.1
    UniProtKB/Swiss-Prot
    Q9H4A9
    UniProtKB/TrEMBL
    A0A024R6Y5
    Related
    ENSP00000377430, OTTHUMP00000174846, ENST00000393847, OTTHUMT00000268873
    Conserved Domains (1) summary
    cd01301
    Location:84396
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...

RNA

  1. NR_136706.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AA404265, AC040162, AK092884

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p2 Primary Assembly

    Range
    67987390..68000611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011523265.1XP_011521567.1  

    See identical proteins and their annotated locations for XP_011521567.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  2. XM_011523274.1XP_011521576.1  

    Conserved Domains (1) summary
    cl00281
    Location:29204
    metallo-dependent_hydrolases; Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a ...
  3. XM_011523273.1XP_011521575.1  

    See identical proteins and their annotated locations for XP_011521575.1

    Conserved Domains (1) summary
    cd01301
    Location:1251
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  4. XM_011523272.1XP_011521574.1  

    See identical proteins and their annotated locations for XP_011521574.1

    Conserved Domains (1) summary
    cd01301
    Location:1251
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  5. XM_011523267.1XP_011521569.1  

    See identical proteins and their annotated locations for XP_011521569.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  6. XM_011523270.1XP_011521572.1  

    Conserved Domains (1) summary
    cd01301
    Location:6286
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  7. XM_011523269.1XP_011521571.1  

    Conserved Domains (1) summary
    cd01301
    Location:12293
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  8. XM_011523266.1XP_011521568.1  

    See identical proteins and their annotated locations for XP_011521568.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  9. XM_011523264.1XP_011521566.1  

    See identical proteins and their annotated locations for XP_011521566.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  10. XM_011523271.1XP_011521573.1  

    Conserved Domains (1) summary
    pfam01244
    Location:79306
    Peptidase_M19; Membrane dipeptidase (Peptidase family M19)
  11. XM_005256090.3XP_005256147.2  

    Conserved Domains (1) summary
    cd01301
    Location:84360
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  12. XM_011523268.1XP_011521570.1  

    Conserved Domains (1) summary
    cd01301
    Location:84401
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  13. XM_011523262.1XP_011521564.1  

    See identical proteins and their annotated locations for XP_011521564.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...
  14. XM_011523263.1XP_011521565.1  

    See identical proteins and their annotated locations for XP_011521565.1

    Conserved Domains (1) summary
    cd01301
    Location:84409
    rDP_like; renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics. ...

RNA

  1. XR_933390.1 RNA Sequence

  2. XR_933389.1 RNA Sequence

  3. XR_933391.1 RNA Sequence

  4. XR_933392.1 RNA Sequence

  5. XR_243420.3 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018927.2 Alternate CHM1_1.1

    Range
    69429363..69441488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)