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MAP2K4 mitogen-activated protein kinase kinase 4 [ Homo sapiens (human) ]

Gene ID: 6416, updated on 26-May-2016
Official Symbol
MAP2K4provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase 4provided by HGNC
Primary source
HGNC:HGNC:6844
See related
Ensembl:ENSG00000065559 HPRD:03213; MIM:601335; Vega:OTTHUMG00000178267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JNKK; MEK4; MKK4; SEK1; SKK1; JNKK1; SERK1; MAPKK4; PRKMK4; SAPKK1; SAPKK-1
Summary
This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Orthologs
Location:
17p12
Exon count:
15
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (12020818..12143831)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (11924135..12047148)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371539 Neighboring gene ribosomal protein L21 pseudogene 122 Neighboring gene zinc finger protein 18 Neighboring gene dynein light chain Tctex-type 1 pseudogene Neighboring gene microRNA 744 Neighboring gene long intergenic non-protein coding RNA 670 Neighboring gene uncharacterized LOC105371540 Neighboring gene uncharacterized LOC101928418 Neighboring gene myocardin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
receptor signaling protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of motor neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
proteolysis in other organism TAS
Traceable Author Statement
more info
 
response to wounding IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dual specificity mitogen-activated protein kinase kinase 4
Names
JNK-activated kinase 1
JNK-activating kinase 1
MAP kinase kinase 4
MAPK/ERK kinase 4
MAPKK 4
MEK 4
SAPK/ERK kinase 1
c-Jun N-terminal kinase kinase 1
stress-activated protein kinase kinase 1
NP_001268364.1
NP_003001.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033952.1 RefSeqGene

    Range
    5001..128014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001281435.1NP_001268364.1  dual specificity mitogen-activated protein kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001268364.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is longer compared to isoform 1.
    Source sequence(s)
    AC005244, AC005410, AK131544, AU150695
    Consensus CDS
    CCDS62095.1
    UniProtKB/Swiss-Prot
    P45985
    Related
    ENSP00000410402, OTTHUMP00000258969, ENST00000415385, OTTHUMT00000441227
    Conserved Domains (2) summary
    smart00220
    Location:114378
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:106396
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4
  2. NM_003010.3NP_003001.1  dual specificity mitogen-activated protein kinase kinase 4 isoform 1

    See identical proteins and their annotated locations for NP_003001.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AU150695, BC036032, BQ028457, L36870
    Consensus CDS
    CCDS11162.1
    UniProtKB/Swiss-Prot
    P45985
    Related
    ENSP00000262445, OTTHUMP00000258968, ENST00000353533, OTTHUMT00000441226
    Conserved Domains (2) summary
    smart00220
    Location:103367
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:95385
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

    Range
    12020818..12143831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005256755.1XP_005256812.1  

    See identical proteins and their annotated locations for XP_005256812.1

    Conserved Domains (2) summary
    smart00220
    Location:6221
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  2. XM_011523977.1XP_011522279.1  

    See identical proteins and their annotated locations for XP_011522279.1

    Conserved Domains (2) summary
    smart00220
    Location:6221
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1239
    PKc_like; Protein Kinases, catalytic domain
  3. XM_011523976.1XP_011522278.1  

    Conserved Domains (2) summary
    smart00220
    Location:114310
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:106309
    PKc_like; Protein Kinases, catalytic domain
  4. XM_005256753.1XP_005256810.1  

    See identical proteins and their annotated locations for XP_005256810.1

    Conserved Domains (2) summary
    smart00220
    Location:2249
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06616
    Location:1267
    PKc_MKK4; Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4

RNA

  1. XR_934080.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    11933251..12056267
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)