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    Mllt1 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 [ Mus musculus (house mouse) ]

    Gene ID: 64144, updated on 9-May-2013
    Official Symbol
    Mllt1provided by MGI
    Official Full Name
    myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1provided by MGI
    Primary source
    MGI:1927238
    See related
    Ensembl:ENSMUSG00000024212
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ENL; BAM11; LTG19; AA407901
    Location :
    17; 17 E1.1
    Sequence :
    Chromosome: 17; NC_000083.6 (56892611..56935388, complement)
    See Mllt1 in Epigenomics, MapViewer

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase bubblegum family member 2 Neighboring gene RIKEN cDNA 1700061G19 gene Neighboring gene alkaline ceramidase 1 Neighboring gene ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953.
    2. Misguided transcriptional elongation causes mixed lineage leukemia. Mueller D, et al. PLoS Biol, 2009 Nov. PMID 19956800.
    3. Foxl2 functions in sex determination and histogenesis throughout mouse ovary development. Garcia-Ortiz JE, et al. BMC Dev Biol, 2009 Jun 18. PMID 19538736.
    4. Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities. Horton SJ, et al. Blood, 2009 May 14. PMID 19029444.
    5. Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse. Vogel T, et al. Gene Expr Patterns, 2009 Feb. PMID 19000783.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Even genetically complex leukemias can be reversed on inactivation of the initiating MLL fusion.
      Title: Acute myeloid leukemia induced by MLL-ENL is cured by oncogene ablation despite acquisition of complex genetic abnormalities.
    2. Overlapping expression of Af9 with Af4/Aff1 and Fmr2/Aff2, two genes that are also related to neurodevelopmental diseases, as well as with the highly homologous Enl.
      Title: Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouse.
    3. An intimate association between MLL and RNA pol II occurs at MLL target genes in vivo that is required for normal initiation and/or transcriptional elongation.
      Title: MLL associates specifically with a subset of transcriptionally active target genes.
    4. characterization of gene structure, mapping to chromosome 17, and demonstration of an essential role in embryonic development
      Title: The leukemia-associated gene Mllt1/ENL: characterization of a murine homolog and demonstration of an essential role in embryonic development.
    5. demonstrate BAM11 transcriptional co-activation activity and its functional interaction with Btk
      Title: Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes.
    Submit: New GeneRIF Correction
    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:211034 BioGRID:198400 Btk    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:211034 BioGRID:228971 Dot1l    BioGRID  PubMed Two-hybrid 
    BioGRID:211034 BioGRID:202919 Rnf2    BioGRID  PubMed Affinity Capture-MS 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    negative regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Preferred Names
    protein ENL
    Names
    protein ENL
    trithorax
    leukemia-associated protein MLLT1
    myeloid/lymphoid or mixed lineage-leukemia translocation to 1 homolog
    myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022328.2 → NP_071723.1  protein ENL

      Status: PROVISIONAL

      Source sequence(s)
      BC053005
      Consensus CDS
      CCDS28918.1
      UniProtKB/TrEMBL
      Q9ERL0
      Related
      ENSMUSP00000025053, ENSMUST00000025053
      Conserved Domains (1) summary
      pfam03366
      Location:29 – 112
      Blast Score: 295
      YEATS; YEATS family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p1 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p1 C57BL/6J

      Range
      56892611..56935388, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000039.1 Alternate Mm_Celera

      Range
      61237292..61280070, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AAHY01133659.1 (85131..127909) None
    genomic AC073683.3 (72445..115222) None
    genomic AF438331.1 AAN03013.1 129/SvJ
    genomic AF438332.1 AAN03013.1 129/SvJ
    genomic AF438333.1 AAN03013.1 129/SvJ
    genomic AF438334.1 AAN03013.1 129/SvJ
    genomic AF438335.1 AAN03013.1 129/SvJ
    genomic AF438336.1 AAN03013.1 129/SvJ
    genomic AF438337.1 AAN03013.1 129/SvJ
    genomic AF438338.1 AAN03013.1 129/SvJ
    genomic AF438339.1 AAN03013.1 129/SvJ
    genomic CH466537.1 EDL38212.1 mixed
      EDL38213.1 mixed
    mRNA AF298887.1 AAG22079.1 BALB/c
    mRNA AF312858.1 AAG40286.1
    mRNA AK144605.1 BAE25964.1
    mRNA AK147804.1 None C57BL/6J
    mRNA AK156820.1 BAE33866.1 NOD
    mRNA AK178669.1 None
    mRNA AK180836.1 None
    mRNA AK184000.1 None
    mRNA AK191939.1 None
    mRNA AK194830.1 None
    mRNA AK196380.1 None
    mRNA AK197112.1 None
    mRNA AK199774.1 None
    mRNA AK206613.1 None
    mRNA AK211968.1 None
    mRNA AK212904.1 None
    mRNA BC053005.1 AAH53005.1 C57BL/6
    mRNA BC139810.1 AAI39811.1

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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    Research Materials
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      Supplemental Content

      Table of contents

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      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
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        Related GEO
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        Link to related Nucleotide entry
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        Related Probe entry
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        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
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        Gene Genotype Report
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

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