SEMG2 semenogelin II [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: SEMG2provided by HGNC
Official Full Name: semenogelin IIprovided by HGNC
Primary source: HGNC:10743
See related: Ensembl:ENSG00000124157; HPRD:01642; MIM:182141; Vega:OTTHUMG00000032566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGII
Summary: The secreted protein encoded by this gene is involved in the formation of a gel matrix that encases ejaculated spermatozoa. Proteolysis by the prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely. The encoded protein is found in lesser abundance than a similar semenogelin protein. The genes encoding these two semenogelin proteins are found in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 20q12-q13.1

Sequence :: Chromosome: 20; NC_000020.10 (43850010..43853099)

See SEMG2 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy.
Title: Expression of semenogelins I and II and its prognostic significance in human prostate cancer.
Semenogelins (Sgs) modifies the membrane structure, indirectly inhibiting motility, and provides suggestions for a therapy for male infertility through selection of a functional sperm population using Sgs.
Title: Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans.
antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
Title: The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity.
Title: Major role of human KLK14 in seminal clot liquefaction.
SGII is a novel target for protein S-nitrosylation in spermatozoa.
Title: Human spermatozoa contain multiple targets for protein S-nitrosylation: an alternative mechanism of the modulation of sperm function by nitric oxide?
SgII transcripts were demonstrated in several tissues, with the strongest signals coming from seminal vesicles, vas deferens, prostate, epididymis and trachea.
Title: Semenogelin I and II, the predominant human seminal plasma proteins, are also expressed in non-genital tissues.
The binding of Zn2+ to SgI and SgII and their involvment in regulating the activity of PSA are reported.
Title: Semenogelins I and II bind zinc and regulate the activity of prostate-specific antigen.
Seminal plasma motility inhibitor, one of the fragments of Sg, has its inhibitory effect on ejaculated spermatozoa in liquefied semen under physiological conditions.
Title: Quantification of seminal plasma motility inhibitor/semenogelin in human seminal plasma.
structural changes in the semenogelin 1 and 2 proteins that have arisen since the human-chimpanzee-gorilla split may be responsible for the physiological differences between these species ejaculated semen that correlate with their sociosexual behavior
Title: Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.

Submit: New GeneRIF Correction

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
Q02383	P20151	KLK2	HPRD	PubMed
Q02383	P07288	KLK3	HPRD	PubMed
Q02383	P13861	PRKAR2A	HPRD	PubMed
Q02383	P17252	PRKCA	HPRD	PubMed
Q02383	P04279	SEMG1	HPRD	PubMed
Q02383	P05154	SERPINA5	HPRD	PubMed
Q02383	P22735	TGM1	HPRD	PubMed
BioGRID:112307	BioGRID:112306	SEMG1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112307	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
sexual reproduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
extracellular space	TAS Traceable Author Statement more info	PubMed
secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: semenogelin-2

Names: semenogelin-2; Semenogelin 2

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003008.2 → NP_002999.1 semenogelin-2 precursor

Status: REVIEWED

Source sequence(s)

M81652

Consensus CDS

CCDS13346.1

UniProtKB/Swiss-Prot

Q02383

Related

ENSP00000361855, OTTHUMP00000031099, ENST00000372769, OTTHUMT00000079417

Conserved Domains (1) summary

pfam05474
Location:16 – 436
Blast Score: 1044

Semenogelin; Semenogelin

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

43850010..43853099

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

40591869..40594958

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049767.12	CAB53522.1
genomic	AY259284.1	AAP86625.1
genomic	AY259285.1	AAP86626.1
genomic	AY259286.1	AAP86627.1
genomic	CH471077.2	EAW75870.1
genomic	M81651.1	AAA60313.1
genomic	Z47556.1	CAA87637.1
mRNA	AK312932.1	BAG35775.1
mRNA	BC005262.1	AAH05262.1
mRNA	BC056675.1	None
mRNA	BC070306.1	AAH70306.1
mRNA	M81652.1	AAA60562.1