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    TSPYL2 TSPY-like 2 [ Homo sapiens ]

    Gene ID: 64061, updated on 11-May-2012
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    Summary

    Official Symbol
    TSPYL2provided by HGNC
    Official Full Name
    TSPY-like 2provided by HGNC
    Primary source
    HGNC:24358
    Locus tag
    RP1-290F12.2
    See related
    Ensembl:ENSG00000184205; HPRD:06713; MIM:300564; Vega:OTTHUMG00000021597
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA1; CTCL; NP79; TSPX; CINAP; DENTT; SE204; HRIHFB2216
    Summary
    This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]
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    Genomic context

    Location :
    Xp11.2
    Sequence :
    Chromosome: X; NC_000023.10 (53111542..53117728)
    See TSPYL2 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 156, member A Neighboring gene G protein-coupled receptor 173 Neighboring gene uncharacterized LOC100132984 Neighboring gene actin, gamma 1 pseudogene 10

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies. Drakou CE, et al. Proteins, 2012 Jan. PMID 22038794.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Role of the Y-located putative gonadoblastoma gene in human spermatogenesis. Lau YF, et al. Syst Biol Reprod Med, 2011 Feb. PMID 21204751.
    5. Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability. Zhang J, et al. Cell Mol Life Sci, 2010 Jun. PMID 20186459.

    See all (25) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. hCINAP may not simply regulate nucleotide homeostasis, but may have broader functionality, including control of Cajal body assembly and disassembly
      Title: hCINAP is an atypical mammalian nuclear adenylate kinase with an ATPase motif: structural and functional studies.
    2. TSPX is principally expressed in Sertoli cells in the human testis.
      Title: Role of the Y-located putative gonadoblastoma gene in human spermatogenesis.
    3. knockdown of CINAP expression results in marked reduction of histone transcription, lower levels of U small nuclear RNAs (U1, U2, U4, and U5), and a loss of cell viability
      Title: Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability.
    4. This paper characterizes monkey DENTT cDNA and makes a comparison with human and mouse DENTT
      Title: Differentially expressed nucleolar TGF-beta1 target (DENTT) shows tissue-specific nuclear and cytoplasmic localization and increases TGF-beta1-responsive transcription in primates.
    5. a role for DENTT as a suppressor of the tumorigenic phenotype.
      Title: Differentially expressed nucleolar transforming growth factor-beta1 target (DENTT) exhibits an inhibitory role on tumorigenesis.
    6. Overexpression of cell division autoantigen-1 (CDA1) slowed parasite growth and induced expression of bradyzoite-specific proteins. Results showed that changes in host cell transcription can influence the molecular environment for bradyzoite development.
      Title: Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development.
    7. hCINAP is a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus
      Title: Characterization of hCINAP, a novel coilin-interacting protein encoded by a transcript from the transcription factor TAFIID32 locus.
    8. CDA1 induces p53- and MEK/ERK1/2 MAPK-dependent expression of p21 by acting through the p53 responsive element in the p21 promoter and this contributes to its antiproliferative activity
      Title: Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Cell division autoantigen 1 Q7Z2E3 APTX    HPRD  PubMed  
    Cell division autoantigen 1 O14936 CASK    HPRD  PubMed  
    Cell division autoantigen 1 P24941 CDK2    HPRD  PubMed  
    Cell division autoantigen 1 P38432 COIL    HPRD  PubMed  
    Cell division autoantigen 1 Growth factor independent 1B GFI1B    HPRD  PubMed  
    BioGRID:122034 BioGRID:114141 CASK    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:122034 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:122034 BioGRID:114581 CCNB2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:122034 BioGRID:107420 CDK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:122034 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:122034 BioGRID:107454 CDK4    BioGRID  PubMed Biochemical Activity 
    BioGRID:122034 BioGRID:115942 TBR1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:122034 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activation of Chaperone Genes by XBP1(S), organism-specific biosystem (from REACTOME)
      Activation of Chaperone Genes by XBP1(S), organism-specific biosystemXbp-1 (S) binds the sequence CCACG in ER Stress Responsive Elements (ERSE, consensus sequence CCAAT (N)9 CCACG) located upstream from many genes. The ubiquitous transcription factor NF-Y, a heterotri...
    • Activation of Chaperones by IRE1alpha, organism-specific biosystem (from REACTOME)
      Activation of Chaperones by IRE1alpha, organism-specific biosystemIRE1-alpha is a single-pass transmembrane protein that resides in the endoplasmic reticulum (ER) membrane. The C-terminus of IRE1-alpha is located in the cytosol; the N-terminus is located in the ER ...
    • Diabetes pathways, organism-specific biosystem (from REACTOME)
      Diabetes pathways, organism-specific biosystemThis module groups several normal processes that have key roles in the synthesis and function of insulin, insulin-like growth factors and ghrelin, and whose derangement is thus central to the pathoge...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Unfolded Protein Response, organism-specific biosystem (from REACTOME)
      Unfolded Protein Response, organism-specific biosystemThe Unfolded Protein Response (UPR) is a regulatory system that protects the Endoplasmic Reticulum (ER) from overload. The UPR is provoked by the accumulation of improperly folded protein in the ER d...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    rDNA binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    activation of signaling protein activity involved in unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    endoplasmic reticulum unfolded protein response TAS
    Traceable Author Statement
    more info
    		  
    negative regulation of DNA replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    negative regulation of cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    negative regulation of cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of signal transduction NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    testis-specific Y-encoded-like protein 2
    Names
    testis-specific Y-encoded-like protein 2
    TSPY-like protein 2
    CTCL tumor antigen se20-4
    nuclear protein of 79 kDa
    cell division autoantigen 1
    CTCL-associated antigen se20-4
    testis-specific protein Y encoded-like 2
    CASK-interacting nucleosome assembly protein
    cutaneous T-cell lymphoma-associated antigen se20-4
    differentially expressed nucleolar TGF-beta1 target
    cutaneous T-cell lymphoma-associated tumor antigen se20-4
    differentially-expressed nucleolar TGF-beta1 target protein
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013267.1 RefSeqGene

      Range
      5001..11187
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_022117.3 → NP_071400.1  testis-specific Y-encoded-like protein 2

      Status: REVIEWED

      Source sequence(s)
      AI208075, BC024270, DA076199
      Consensus CDS
      CCDS14350.1
      UniProtKB/Swiss-Prot
      Q9H2G4
      Related
      ENSP00000364591, OTTHUMP00000023335, ENST00000375442, OTTHUMT00000056718
      Conserved Domains (2) summary
      cl08298
      Location:227 – 396
      Blast Score: 197
      PTZ00007; (NAP-L) nucleosome assembly protein -L; Provisional
      pfam00956
      Location:216 – 398
      Blast Score: 364
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      53111542..53117728
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      50176603..50182876
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic BX322635.6 CAI42531.1
    genomic CH471154.1 EAW93143.1
      EAW93144.1
    mRNA AB015345.1 BAA34802.1
    mRNA AB209182.1 BAD92419.1
    mRNA AF254794.1 AAG53596.1
    mRNA AF273046.1 AAG34906.1
    mRNA AI208075.1 None
    mRNA AK131220.1 BAG54754.1
    mRNA AK292462.1 BAF85151.1
    mRNA AL713652.1 CAD28461.1
    mRNA AY040871.1 AAK72407.1
    mRNA BC001566.1 AAH01566.1
    mRNA BC024270.1 AAH24270.1
    mRNA DA076199.1 None
    other-genetic AM392716.1 CAL37594.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59GC7 GenPept UniProtKB/TrEMBL:Q59GC7
    Q9H2G4.1 GenPept UniProtKB/Swiss-Prot:Q9H2G4
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

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