SEMG1 semenogelin I [Homo sapiens] - Gene

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Summary

Official Symbol: SEMG1provided by HGNC
Official Full Name: semenogelin Iprovided by HGNC
Primary source: HGNC:10742
See related: Ensembl:ENSG00000124233; HPRD:01641; MIM:182140; Vega:OTTHUMG00000032565
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGI; SEMG; CT103; dJ172H20.2; FLJ78262; MGC14719
Summary: The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. [provided by RefSeq, Jul 2009]

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Genomic context

Location :: 20q12-q13.2

Sequence :: Chromosome: 20; NC_000020.10 (43835638..43838414)

See SEMG1 in Epigenomics, MapViewer

Chromosome 20 - NC_000020.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results suggest the involvement of semenogelins in prostate cancer and their prognostic values in predicting cancer progression after radical prostatectomy.
Title: Expression of semenogelins I and II and its prognostic significance in human prostate cancer.
Spermatozoa interact with semenogelin I in solution in a non-Zn2+-dependent manner, but associate with immobilized semenogelin I only in the presence of Zn2+.
Title: Binding of semenogelin I to intact human spermatozoa studied by flow cytometry and surface plasmon resonance.
Cysteine 239 of rSEMG1 appears to be the critical amino acid for both binding to eppin and inhibiting sperm motility.
Title: Analysis of recombinant human semenogelin as an inhibitor of human sperm motility.
expressed in 46% of patients with early stage chronic lymphocytic leukemia; potential target for cancer vaccines
Title: SEMG-1 expression in early stage chronic lymphocytic leukemia.
Semenogelins (Sgs) modifies the membrane structure, indirectly inhibiting motility, and provides suggestions for a therapy for male infertility through selection of a functional sperm population using Sgs.
Title: Functional implications of membrane modification with semenogelins for inhibition of sperm motility in humans.
SEMG I expression in myeloma cells can be upregulated by 5-azacytidine, IL-4 and IL-6.
Title: Semenogelin I expression in myeloma cells can be upregulated pharmacologically.
antibacterial activity of the semenogelin-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
Title: The major bactericidal activity of human seminal plasma is zinc-dependent and derived from fragmentation of the semenogelins.
semenogelins I and II were directly cleaved by KLK14. Semenogelins were also able to reverse KLK14 inhibition by Zn2+, providing a novel regulatory mechanism for KLK14 activity.
Title: Major role of human KLK14 in seminal clot liquefaction.
Four isolated peptides of semenogelin I had antibacterial activity.
Title: Identification of novel semenogelin I-derived antimicrobial peptide from liquefied human seminal plasma.
The semenogelin-CD52 soluble form is a direct consequence of the liquefaction process in human semen.
Title: The GPI-anchored CD52 antigen of the sperm surface interacts with semenogelin and participates in clot formation and liquefaction of human semen.

Submit: New GeneRIF Correction See all (21)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
P04279	P20151	KLK2	HPRD	PubMed
P04279	P07288	KLK3	HPRD	PubMed
P04279	P17252	PRKCA	HPRD	PubMed
P04279	Q02383	SEMG2	HPRD	PubMed
P04279	P22735	TGM1	HPRD	PubMed
P04279	Q9NRR5	UBQLN4	HPRD	PubMed
BioGRID:112306	BioGRID:112307	SEMG2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:112306	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS; Reconstituted Complex

Function	Evidence Code	Pubs
structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
insemination	TAS Traceable Author Statement more info	PubMed
sexual reproduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info
extracellular space	TAS Traceable Author Statement more info	PubMed
secretory granule	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: semenogelin-1

Names: semenogelin-1; cancer/testis antigen 103; semen coagulating protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003007.3 → NP_002998.1 semenogelin-1 preproprotein

Status: REVIEWED

Source sequence(s)

AA687874, BC055416, DA874748, J04440

Consensus CDS

CCDS13345.1

UniProtKB/Swiss-Prot

P04279

Related

ENSP00000361867, OTTHUMP00000031098, ENST00000372781, OTTHUMT00000079416

Conserved Domains (1) summary

pfam05474
Location:1 – 462
Blast Score: 1259

Semenogelin; Semenogelin

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000020.10 Reference GRCh37.p5 Primary Assembly

Range

43835638..43838414

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000152.1 Alternate HuRef

Range

40577518..40580294

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_198139.1: Suppressed sequence

Description

NM_198139.1: This RefSeq was permanently suppressed because the transcript lacked a 180 nt repeat unit in the coding sequence compared to the reference genome sequence.

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AL049767.12	CAB53523.1
genomic	AY174423.1	AAO20112.1
genomic	AY174424.1	AAO20113.1
genomic	AY174437.1	AAO20126.1
genomic	AY174446.1	AAO20127.1
genomic	AY174447.1	AAO20128.1
genomic	AY174448.1	AAO20129.1
genomic	AY256465.1	AAP82462.1
genomic	AY256466.1	AAP82463.1
genomic	AY256467.1	AAP82464.1
genomic	AY256468.1	AAP82465.1
genomic	AY256469.1	AAP82466.1
genomic	CH471077.2	EAW75871.1
		EAW75872.1
genomic	M81650.1	AAA18168.1
genomic	Z47556.1	CAA87636.1
mRNA	AA687874.1	None
mRNA	BC005229.1	AAH05229.1
mRNA	BC007096.1	AAH07096.1
mRNA	BC011442.1	None
mRNA	BC055416.1	AAH55416.1
mRNA	BT007177.1	AAP35841.1
mRNA	DA874748.1	None
mRNA	J04440.1	AAB59506.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P04279.2	GenPept	UniProtKB/Swiss-Prot:P04279
Q6Y806	GenPept	UniProtKB/TrEMBL:Q6Y806
Q6Y808	GenPept	UniProtKB/TrEMBL:Q6Y808