Casp8 caspase 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

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Official Symbol: Casp8provided by RGD
Official Full Name: caspase 8provided by RGD
Primary source: RGD:620945
See related: Ensembl:ENSRNOG00000012331
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary: member of the cysteine-aspartic acid protease (caspase) familythat mediates the terminal stage of apoptosis; involved in apoptosis induced by Fas and other stimuli [RGD, Feb 2006]

Genomic context

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Location :: 9q31

Sequence :: Chromosome: 9; NC_005108.3 (65420843..65468950)

See Casp8 in MapViewer

Chromosome 9 - NC_005108.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
Title: Sublytic C5b-9 complexes induce apoptosis of glomerular mesangial cells in rats with Thy-1 nephritis through role of interferon regulatory factor-1-dependent caspase 8 activation.
data suggest that caspase-8 does not become activated through an extrinsic but an "intrinsic/intracellular" apoptotic pathway unleashed by the down-regulation of c-FLIP by c-Myc
Title: Caspase-8, c-FLIP, and caspase-9 in c-Myc-induced apoptosis of fibroblasts.
TNF-alpha-induced caspase-8 activation leads to leaky RyR2 channels that contribute to myocardial remodeling after ischemia/reperfusion.
Title: Ryanodine receptor leak mediated by caspase-8 activation leads to left ventricular injury after myocardial ischemia-reperfusion.
Compared with the control group, the expression of Fas mRNA and its protein and caspase-8 mRNA and the activity of caspase-8 and caspase-3 of ovary tissues in the rats treated with formaldehyde significantly increased with dose.
Title: [Effect of formaldehyde on expressions of Fas apoptosis pathway-related genes of ovary tissues in female rats].
The role of N-acetylcysteine (NAC) in coun oxidative stress & apoptosis inhibition induced by stim with hCG in rat Leydig cells was studied. Caspase-8 expression levels were investigated.
Title: N-acetylcysteine counteracts oxidative stress and prevents hCG-induced apoptosis in rat Leydig cells through down regulation of caspase-8 and JNK.
The expression of caspase-8 in injured brain could be detected in 30 min after injury, increased significantly in 3h, reached its apex in 1d after injury, and remained 4d before decreasing.
Title: [Expression of caspase-8 after brain injury from fluid percussion in rats].
mRNA level, protein level and activity of caspase-8 were increased in a dose-dependent manner in livers and lungs of rats after SO(2) inhalation.
Title: Expression of caspase and apoptotic signal pathway induced by sulfur dioxide.
Based on the current data, it could be concluded that high glucose-induced apoptosis in PC12 cells is mediated, in part, by activation of caspase-8, -9, and -3 dependent pathways.
Title: Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells.
Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
Title: Tetrazolium violet induces apoptosis via caspases-8, -9 activation and Fas/FasL up-regulation in rat C6 glioma cells.
CD95L initiates a rapid caspase 8-dependent endosomal acidification
Title: Amplification of CD95 activation by caspase 8-induced endosomal acidification in rat hepatocytes.

Submit: New GeneRIF Correction See all (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
NP_071613.1	NP_077039.2	Cebpb		BIND	PubMed	C/EBP-beta interacts with procaspase 8.
NP_071613.1	NP_690920.1	Fadd		BIND	PubMed	Casp8 interacts with Fadd. This interaction was modelled on a demonstrated interaction between Caspase 8 from rat and Fadd from an unspecified species.

Pathways from BioSystems

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Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
Activated TLR4 signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystem (from REACTOME)
Activation, myristolyation of BID and translocation to mitochondria, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Alzheimer's disease, organism-specific biosystem (from KEGG)
Alzheimer's disease, organism-specific biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Alzheimer's disease, conserved biosystem (from KEGG)
Alzheimer's disease, conserved biosystemAlzheimer's disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-b...
Androgen Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Androgen Receptor Signaling Pathway, organism-specific biosystemThe androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among ot...
Apoptosis, organism-specific biosystem (from WikiPathways)
Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptosis Modulation by HSP70, organism-specific biosystem (from WikiPathways)
Apoptosis Modulation by HSP70, organism-specific biosystem
Apoptosis Modulation by HSP70
Apoptotic cleavage of cellular proteins, organism-specific biosystem (from REACTOME)
Apoptotic cleavage of cellular proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Apoptotic execution phase, organism-specific biosystem (from REACTOME)
Apoptotic execution phase, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Caspase-8 activation, organism-specific biosystem (from REACTOME)
Caspase-8 activation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystem (from REACTOME)
Caspase-mediated cleavage of cytoskeletal proteins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
Death Receptor Signalling, organism-specific biosystem (from REACTOME)
Death Receptor Signalling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Dimerization of procaspase-8, organism-specific biosystem (from REACTOME)
Dimerization of procaspase-8, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Extrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Extrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystem (from WikiPathways)
FAS pathway and Stress induction of HSP regulation, organism-specific biosystemThis pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info: [http://www.biocarta.com/pathfiles/h_hsp27Pathway.asp BioCarta].
FasL/ CD95L signaling, organism-specific biosystem (from REACTOME)
FasL/ CD95L signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hepatitis B, organism-specific biosystem (from KEGG)
Hepatitis B, organism-specific biosystemHepatitis B virus (HBV) is an enveloped virus and contains a partially double-stranded relaxed circular DNA (RC-DNA) genome. After entry into hepatocytes, HBV RC-DNA is transported to the nucleus and...
Herpes simplex infection, organism-specific biosystem (from KEGG)
Herpes simplex infection, organism-specific biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Herpes simplex infection, conserved biosystem (from KEGG)
Herpes simplex infection, conserved biosystemHerpes simplex virus (HSV) infections are very common worldwide, with the prevalence of HSV-1 reaching up to 80%-90%. Primary infection with HSV takes place in the mucosa, followed by the establishme...
Huntington's disease, organism-specific biosystem (from KEGG)
Huntington's disease, organism-specific biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Huntington's disease, conserved biosystem (from KEGG)
Huntington's disease, conserved biosystemHuntington disease (HD) is an autosomal-dominant neurodegenerative disorder that primarily affects medium spiny striatal neurons (MSN). The symptoms are choreiform, involuntary movements, personality...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Legionellosis, organism-specific biosystem (from KEGG)
Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
Legionellosis, conserved biosystem (from KEGG)
Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MyD88-independent cascade, organism-specific biosystem (from REACTOME)
MyD88-independent cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystem (from REACTOME)
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10, organism-specific biosystemcomputationally inferred pathway (not manually curated)
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
NOD1/2 Signaling Pathway, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TNF signaling, organism-specific biosystem (from REACTOME)
TNF signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF-alpha NF-kB Signaling Pathway, organism-specific biosystem
TNF-alpha NF-kB Signaling Pathway
TRAIL signaling, organism-specific biosystem (from REACTOME)
TRAIL signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystem (from REACTOME)
TRIF-mediated TLR3/TLR4 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
TRIF-mediated programmed cell death, organism-specific biosystem (from REACTOME)
TRIF-mediated programmed cell death, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 3 (TLR3) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-Like Receptors Cascades, organism-specific biosystem (from REACTOME)
Toll-Like Receptors Cascades, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Toll-like receptor signaling pathway, organism-specific biosystem
Toll-like receptor signaling pathway
Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
Toxoplasmosis, organism-specific biosystem (from KEGG)
Toxoplasmosis, organism-specific biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Toxoplasmosis, conserved biosystem (from KEGG)
Toxoplasmosis, conserved biosystemToxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechan...
Tuberculosis, organism-specific biosystem (from KEGG)
Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Tuberculosis, conserved biosystem (from KEGG)
Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
Viral carcinogenesis, organism-specific biosystem (from KEGG)
Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral carcinogenesis, conserved biosystem (from KEGG)
Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
p53 pathway, organism-specific biosystem (from WikiPathways)
p53 pathway, organism-specific biosystemp53 (also known as protein 53 or tumor protein 53), is a transcription factor which in humans is encoded by the TP53 gene. p53 is important in multicellular organisms, where it regulates the cell cyc...
p53 signal pathway, organism-specific biosystem (from WikiPathways)
p53 signal pathway, organism-specific biosystemWe've used the following pathway as a reference: http://www.genome.jp/dbget-bin/show_pathway?rno04115+58918
p53 signaling pathway, organism-specific biosystem (from KEGG)
p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
p53 signaling pathway, conserved biosystem (from KEGG)
p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...

General gene information

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Homology

Homologs of the Casp8 gene: The Casp8 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, chicken, and zebrafish.
Map Viewer (Human, Mouse)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
identical protein binding	IEA Inferred from Electronic Annotation more info
identical protein binding	ISO Inferred from Sequence Orthology more info
peptidase activity	ISO Inferred from Sequence Orthology more info
protease binding	IEA Inferred from Electronic Annotation more info
protease binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
tumor necrosis factor receptor binding	IPI Inferred from Physical Interaction more info

Process	Evidence Code	Pubs
activation of cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
angiogenesis	IEA Inferred from Electronic Annotation more info
angiogenesis	ISO Inferred from Sequence Orthology more info
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic process	ISO Inferred from Sequence Orthology more info
apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
cellular response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
cellular response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
extrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
heart development	IEA Inferred from Electronic Annotation more info
heart development	ISO Inferred from Sequence Orthology more info
macrophage differentiation	IEA Inferred from Electronic Annotation more info
macrophage differentiation	ISO Inferred from Sequence Orthology more info
metabolic process	ISO Inferred from Sequence Orthology more info
negative regulation of I-kappaB kinase/NF-kappaB cascade	IEA Inferred from Electronic Annotation more info
negative regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
neural tube formation	IEA Inferred from Electronic Annotation more info
neural tube formation	ISO Inferred from Sequence Orthology more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	IEA Inferred from Electronic Annotation more info
positive regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
positive regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
positive regulation of proteolysis	ISO Inferred from Sequence Orthology more info
protein heterooligomerization	IDA Inferred from Direct Assay more info	PubMed
proteolysis	IDA Inferred from Direct Assay more info	PubMed
proteolysis	ISO Inferred from Sequence Orthology more info
proteolysis involved in cellular protein catabolic process	IEA Inferred from Electronic Annotation more info
proteolysis involved in cellular protein catabolic process	ISO Inferred from Sequence Orthology more info
response to antibiotic	IEP Inferred from Expression Pattern more info	PubMed
response to cobalt ion	IEP Inferred from Expression Pattern more info	PubMed
response to cold	IEP Inferred from Expression Pattern more info	PubMed
response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
response to ethanol	IDA Inferred from Direct Assay more info	PubMed
response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info
response to tumor necrosis factor	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
CD95 death-inducing signaling complex	IDA Inferred from Direct Assay more info	PubMed
Noc1p-Noc2p complex	IEA Inferred from Electronic Annotation more info
Noc1p-Noc2p complex	ISO Inferred from Sequence Orthology more info
cell body	IDA Inferred from Direct Assay more info	PubMed
centrosome	IEA Inferred from Electronic Annotation more info
centrosome	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
cytosol	IDA Inferred from Direct Assay more info	PubMed
death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
membrane raft	IDA Inferred from Direct Assay more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info
mitochondrion	ISO Inferred from Sequence Orthology more info
neuron projection	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	ISO Inferred from Sequence Orthology more info
protein complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: caspase-8

Names: caspase-8

NP_071613.1

EC 3.4.22.61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022277.1 → NP_071613.1 caspase-8

Status: PROVISIONAL

Source sequence(s)

AF279308

UniProtKB/TrEMBL

Q9JHX4

Related

ENSRNOP00000016613, ENSRNOT00000016613

Conserved Domains (2) summary

cd00032
Location:227 – 480
Blast Score: 726

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

cl14633
Location:98 – 179
Blast Score: 283

DD_superfamily; The Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_5.0 Primary Assembly

Genomic

NC_005108.3 Reference Rnor_5.0 Primary Assembly

Range

65420843..65468950

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

AC_000077.1 Alternate Rn_Celera

Range

57705001..57753027

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AABR06060567.1 (116554..129671)	None
genomic	AABR06060568.1	None
genomic	AAHX01060243.1	None
genomic	AAHX01060244.1	None
genomic	AAHX01060245.1 (21498..56438)	None
genomic	CH473965.2	EDL98978.1
		EDL98979.1
mRNA	AF279308.1	AAF87778.1	Sprague-Dawley
mRNA	AF288372.1	AAK83055.1	Sprague-Dawley
mRNA	FQ226407.1	None	Sprague-Dawley