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    SDHC succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa [ Homo sapiens ]

    Gene ID: 6391, updated on 12-May-2012

    Summary

    Official Symbol
    SDHCprovided by HGNC
    Official Full Name
    succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDaprovided by HGNC
    Primary source
    HGNC:10682
    See related
    Ensembl:ENSG00000143252; HPRD:03878; MIM:602413; Vega:OTTHUMG00000034468
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CYBL; PGL3; QPS1; SDH3; CYB560
    Summary
    This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. Several related pseudogenes are located in different genomic regions. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    1q23.3
    Sequence :
    Chromosome: 1; NC_000001.10 (161284166..161334541)
    See SDHC in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene Purkinje cell protein 4 like 1 Neighboring gene myelin protein zero Neighboring gene chromosome 1 open reading frame 192 Neighboring gene ribonucleotide reductase M2 polypeptide pseudogene 2 Neighboring gene uncharacterized LOC100505703 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:112292 BioGRID:106889 ARHGDIA    BioGRID  PubMed Two-hybrid 
    BioGRID:112292 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112292 BioGRID:108822 XRCC6    BioGRID  PubMed Two-hybrid 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    electron carrier activity IEA
    Inferred from Electronic Annotation
    more info
     
    heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    succinate dehydrogenase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    aerobic respiration TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidation-reduction process TAS
    Traceable Author Statement
    more info
    PubMed 
    respiratory electron transport chain TAS
    Traceable Author Statement
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    transport IEA
    Inferred from Electronic Annotation
    more info
     
    tricarboxylic acid cycle TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    integral to membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
     
    mitochondrial respiratory chain complex II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion TAS
    Traceable Author Statement
    more info
    PubMed 
    respiratory chain complex II TAS
    Traceable Author Statement
    more info
    PubMed 
    succinate dehydrogenase complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    succinate dehydrogenase cytochrome b560 subunit, mitochondrial
    Names
    succinate dehydrogenase cytochrome b560 subunit, mitochondrial
    QPs-1
    integral membrane protein CII-3
    integral membrane protein CII-3b
    cytochrome B large subunit of complex II
    succinate dehydrogenase complex subunit C
    succinate-ubiquinone oxidoreductase cytochrome B large subunit
    succinate-ubiquinone oxidoreducatase cytochrome B large subunit

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012767.1 RefSeqGene

      Range
      5001..55376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001035511.1NP_001030588.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AB211235, AL592295, BG724095, D49737
      Consensus CDS
      CCDS41431.1
      UniProtKB/Swiss-Prot
      Q99643
      Related
      ENSP00000356952, OTTHUMP00000217417, ENST00000342751, OTTHUMT00000359060
      Conserved Domains (1) summary
      cd03499
      Location:5079
      Blast Score: 127
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
    2. NM_001035512.1NP_001030589.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the coding region compared to variant 1 but maintains the reading frame. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB211234, AL592295, BG724095, D49737
      Consensus CDS
      CCDS44263.1
      UniProtKB/Swiss-Prot
      Q99643
      Related
      ENSP00000390558, OTTHUMP00000217418, ENST00000432287, OTTHUMT00000359062
      Conserved Domains (1) summary
      cd03499
      Location:19134
      Blast Score: 213
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
    3. NM_001035513.1NP_001030590.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two exons in the 5' coding region compared to variant 1 but maintains the reading frame. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB201252, AL592295, BG724095, D49737
      Consensus CDS
      CCDS41432.1
      UniProtKB/Swiss-Prot
      Q99643
      Related
      ENSP00000376009, OTTHUMP00000217419, ENST00000392169, OTTHUMT00000359063
      Conserved Domains (1) summary
      cd03499
      Location:899
      Blast Score: 189
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
    4. NM_003001.3NP_002992.1  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL592295, BC033626, BG724095
      Consensus CDS
      CCDS1230.1
      UniProtKB/Swiss-Prot
      Q99643
      Related
      ENSP00000356953, OTTHUMP00000032375, ENST00000367975, OTTHUMT00000083316
      Conserved Domains (1) summary
      cd03499
      Location:50168
      Blast Score: 265
      SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      161284166..161334541
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      132641002..132691319
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

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