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    FAM111A family with sequence similarity 111, member A [ Homo sapiens ]

    Gene ID: 63901, updated on 11-May-2012
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    Summary

    Official Symbol
    FAM111Aprovided by HGNC
    Official Full Name
    family with sequence similarity 111, member Aprovided by HGNC
    Primary source
    HGNC:24725
    See related
    Ensembl:ENSG00000166801; HPRD:07015; Vega:OTTHUMG00000167280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLJ22794; KIAA1895; DKFZp686A06175
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    Genomic context

    Location :
    11q12.1
    Sequence :
    Chromosome: 11; NC_000011.9 (58910318..58922512)
    See FAM111A in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 111, member B Neighboring gene protein kinase, cAMP-dependent, regulatory, type II, beta pseudogene Neighboring gene deltex homolog 4 (Drosophila) Neighboring gene macrophage expressed 1 Neighboring gene tryptophanyl-tRNA synthetase, cytoplasmic-like

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. Danielsen JM, et al. Mol Cell Proteomics, 2011 Mar. PMID 21139048.
    3. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. Vanderwerf SM, et al. Blood, 2009 Dec 17. PMID 19850743.
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560.
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334.

    See all (8) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:121979 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    protein FAM111A
    Names
    protein FAM111A
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001142519.1 → NP_001135991.1  protein FAM111A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK025319, AK291453, DA502464, DB218857
      Consensus CDS
      CCDS7973.1
      UniProtKB/Swiss-Prot
      Q96PZ2
      Related
      ENSP00000434435, OTTHUMP00000235598, ENST00000528737, OTTHUMT00000393975
      Conserved Domains (1) summary
      cl00149
      Location:370 – 555
      Blast Score: 161
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    2. NM_001142520.1 → NP_001135992.1  protein FAM111A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AK025319, AK291453, CR747277, DA502464, DB218857
      Consensus CDS
      CCDS7973.1
      UniProtKB/Swiss-Prot
      Q96PZ2
      Related
      ENSP00000406683, ENST00000420244
      Conserved Domains (1) summary
      cl00149
      Location:370 – 555
      Blast Score: 161
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    3. NM_001142521.1 → NP_001135993.1  protein FAM111A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK025319, AK291453, CR747277, DA502464, DB218857
      Consensus CDS
      CCDS7973.1
      UniProtKB/Swiss-Prot
      Q96PZ2
      Conserved Domains (1) summary
      cl00149
      Location:370 – 555
      Blast Score: 161
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    4. NM_022074.3 → NP_071357.2  protein FAM111A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK025319, AK291453, DA502464
      Consensus CDS
      CCDS7973.1
      UniProtKB/Swiss-Prot
      Q96PZ2
      Related
      ENSP00000355264, OTTHUMP00000235599, ENST00000361723, OTTHUMT00000393976
      Conserved Domains (1) summary
      cl00149
      Location:370 – 555
      Blast Score: 161
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    5. NM_198847.2 → NP_942144.1  protein FAM111A

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK025319, AK291453, DA502464, DB218857
      Consensus CDS
      CCDS7973.1
      UniProtKB/Swiss-Prot
      Q96PZ2
      Related
      ENSP00000433154, OTTHUMP00000235600, ENST00000533703, OTTHUMT00000393977
      Conserved Domains (1) summary
      cl00149
      Location:370 – 555
      Blast Score: 161
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      58910318..58922512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      55256557..55268742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP001258.4 (89476..99736) None
    genomic CH471076.1 EAW73834.1
      EAW73835.1
      EAW73836.1
      EAW73837.1
    mRNA AB067482.1 BAB67788.1
    mRNA AK025319.1 None
    mRNA AK026447.1 BAB15486.1
    mRNA AK092061.1 None
    mRNA AK092237.1 None
    mRNA AK092953.1 None
    mRNA AK130799.1 None
    mRNA AK291453.1 BAF84142.1
    mRNA BC013137.1 AAH13137.1
    mRNA BC041693.1 None
    mRNA BC054515.1 AAH54515.1
    mRNA BC071759.1 AAH71759.1
    mRNA BQ420366.1 None
    mRNA BU428612.1 None
    mRNA CR747277.1 None
    mRNA CR749358.1 CAH18211.1
    mRNA DA502464.1 None
    mRNA DB218857.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96PZ2.2 GenPept UniProtKB/Swiss-Prot:Q96PZ2
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    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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