Display Settings:

Format

Send to:

Choose Destination

SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) [ Homo sapiens (human) ]

Gene ID: 6390, updated on 19-Jul-2014
Official Symbol
SDHBprovided by HGNC
Official Full Name
succinate dehydrogenase complex, subunit B, iron sulfur (Ip)provided by HGNC
Primary source
HGNC:10681
See related
Ensembl:ENSG00000117118; HPRD:01707; MIM:185470; Vega:OTTHUMG00000002289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Summary
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]
See SDHB in Epigenomics, MapViewer
Location:
1p36.1-p35
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (17018722..17054170, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (17345217..17380665, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene microfibrillar-associated protein 2 Neighboring gene ATPase type 13A2 Neighboring gene peptidyl arginine deiminase, type II Neighboring gene uncharacterized LOC400743

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Professional guidelines

Description
Professional guideline
ACMG 2013

The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in SDHB that are pathogenic or expected to be pathogenic.

GuidelinePubMed

NHGRI GWAS Catalog

Description
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat downregulates succinate dehydrogenase complex, subunit B, iron sulfur (SDHB) expression in Jurkat T-cells PubMed
tat Using a yeast two-hybrid system, HIV-1 Tat has been shown to bind the human succinate-ubiquinone oxidoreductase iron sulfur subunit, suggesting a role for this protein in mediating the biological activity of Tat during HIV-1 replication PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ92337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
3 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
4 iron, 4 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
electron carrier activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
succinate dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 
ubiquinone binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
aerobic respiration TAS
Traceable Author Statement
more info
PubMed 
cellular metabolic process TAS
Traceable Author Statement
more info
 
respiratory electron transport chain TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
succinate metabolic process IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
 
tricarboxylic acid cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex II ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrion TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Names
succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
iron-sulfur subunit of complex II
NP_002991.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012340.1 

    Range
    5001..40449
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_316

mRNA and Protein(s)

  1. NM_003000.2NP_002991.2  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial precursor

    See proteins identical to NP_002991.2

    Status: REVIEWED

    Source sequence(s)
    BC007840, BF796275, BU554163
    Consensus CDS
    CCDS176.1
    UniProtKB/Swiss-Prot
    P21912
    Related
    ENSP00000364649, OTTHUMP00000002396, ENST00000375499, OTTHUMT00000006603
    Conserved Domains (3) summary
    PLN00129
    Location:5271
    Blast Score: 1209
    PLN00129; succinate dehydrogenase [ubiquinone] iron-sulfur subunit
    cd00207
    Location:56109
    Blast Score: 83
    fer2; 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis ...
    pfam13534
    Location:185258
    Blast Score: 118
    Fer4_17; 4Fe-4S dicluster domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    17018722..17054170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    15589311..15624677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    17453561..17489010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)